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HIV-Risk Behavior Among Adults with Opioid Use Disorder During 12 Months Following Pre-trial Detention: Results from a Randomized Trial of Methadone Treatment

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Abstract

This was a three group randomized clinical trial of interim methadone and patient navigation involving 225 pre-trial detainees with opioid use disorder in Baltimore. The HIV Risk Assessment Battery (RAB) was administered at baseline (in jail), and at 6 and 12 months post-release. Generalized linear mixed model analyses indicated the condition × time interaction effect failed to reach significance (ps > .05) for both the drug risk and sex risk subscale scores. Therefore, findings suggest that there were no intervention effects on drug or sex risk behaviors. However, increased use of cocaine at baseline was associated with increases in drug- (b = .04, SE = .02) and sex-risk (b = .01, SE = .003) behaviors. These results suggest that interventions targeting cocaine use among pre-trial detainees may serve as a means of reducing HIV risk associated with drug- and sex-risk behaviors.

Clinical Trials Registration: Clinicaltrials.gov NCT 02334215.

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Funding

This work was supported by National Institute on Drug Abuse (NIDA) Grant No. 2 U01 DA01363 and the Laura and John Arnold Foundation. NIDA, the National Institutes of Health, and the Arnold Foundation had no role in the design and conduct of the study; data acquisition, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders.

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Authors and Affiliations

  1. Friends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD, 21201, USA

    M. M. Mitchell, S. M. Kelly, J. H. Jaffe, S. G. Mitchell & R. P. Schwartz

  2. Department of Psychology, University of Maryland, College Park, MD, USA

    K. E. O’Grady

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Correspondence to M. M. Mitchell.

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Dr. Schwartz reports providing consultation to Verily Life Sciences. No financial disclosures were reported by the other authors.

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Mitchell, M.M., Kelly, S.M., O’Grady, K.E. et al. HIV-Risk Behavior Among Adults with Opioid Use Disorder During 12 Months Following Pre-trial Detention: Results from a Randomized Trial of Methadone Treatment. AIDS Behav 25, 1247–1256 (2021). https://doi.org/10.1007/s10461-020-03090-y

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