Abstract
The main goal of this study is the quantification of the particle transport and deposition within the human airways during light, normal and exercise breathing conditions using the computational fluid dynamics. In particular we presented a comparison between healthy and stented airways. The considered tracheobronchial model is based on the Weibel symmetric model in which we have inserted the Dumon prosthesis at different locations and on the CT-based geometries of a healthy and a stented airway. The results indicate an important redistribution of the particle deposition locations. Local overdoses can be found in the proximal regions of the prostheses, independently of the breathing conditions, of the particle size and of the considered geometry. The presented work is aimed to contribute to the understanding of the particle deposition in the human lung and to improve drug-aerosol therapies. For patients that underwent airways reconstructive surgery, it can give detailed information about the deposition efficiency and it may help targeting specific airways regions.
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Acknowledgments
The authors gratefully acknowledge the support of the Spanish Ministry of Industry and Competitiveness through the research Project DPI2017-83259-R (AEI/FEDER,UE). The support of the Instituto de Salud Carlos III (ISCIII) through the CIBER-BBN initiative is highly appreciated.
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Associate Editor Ender A. Finol oversaw the review of this article.
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Malvè, M., Sánchez-Matás, C. & López-Villalobos, J.L. Modelling Particle Transport and Deposition in the Human Healthy and Stented Tracheobronchial Airways. Ann Biomed Eng 48, 1805–1820 (2020). https://doi.org/10.1007/s10439-020-02493-1
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DOI: https://doi.org/10.1007/s10439-020-02493-1