Skip to main content
SpringerLink
Log in

A Novel Plasma-Based Fluid for Particle Image Velocimetry (PIV): In-Vitro Feasibility Study of Flow Diverter Effects in Aneurysm Model

  • Published:
Annals of Biomedical Engineering Aims and scope Submit manuscript

Abstract

Particle image velocimetry (PIV) is a commonly used method for in vitro investigation of fluid dynamics in biomedical devices, such as flow diverters for intracranial aneurysm treatment. Since it is limited to transparent blood substituting fluids like water-glycerol mixture, the influence of coagulation and platelet aggregation is neglected. We aimed at the development and the application of a modified platelet rich plasma as a new PIV fluid with blood-like rheological and coagulation properties. In standardized intracranial aneurysm silicone models, the effect of this new PIV plasma on the fluid dynamics before and after flow diverter implantation was evaluated and compared with water-glycerol measurements. The flow diverting effect was strongly dependent on the used fluid, with considerably lower velocities achieved using PIV plasma, despite the same starting viscosity of both fluids. Moreover, triggering coagulation of PIV plasma allowed for intra-aneurysmal clot formation. We presented the first in vitro PIV investigation using a non-Newtonian, clottable PIV plasma, demonstrating a mismatch to a standard PIV fluid and allowing for thrombus formation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5

Similar content being viewed by others

References

  1. Augsburger, L., M. Farhat, P. Reymond, E. Fonck, Z. Kulcsar, N. Stergiopulos, and D. A. Rüfenacht. Effect of flow diverter porosity on intraaneurysmal blood flow. Clin. Neuroradiol. 19(3):204–214, 2009.

    Article  Google Scholar 

  2. Becske, T., W. Brinjikji, M. B. Potts, D. F. Kallmes, M. Shapiro, C. J. Moran, E. I. Levy, C. G. McDougall, I. Szikora, G. Lanzino, et al. Long-Term clinical and angiographic outcomes following pipeline embolization device treatment of complex internal carotid artery aneurysms: five-year results of the pipeline for uncoilable or failed aneurysms trial. Neurosurgery 80(1):40–48, 2017.

    PubMed  Google Scholar 

  3. Bouillot, P., O. Brina, R. Ouared, K.-O. Lovblad, M. Farhat, and V. M. Pereira. Particle imaging velocimetry evaluation of intracranial stents in sidewall aneurysm: hemodynamic transition related to the stent design. PLoS ONE 9(12):e113762, 2014.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Boussel, L., V. Rayz, C. McCulloch, A. Martin, G. Acevedo-Bolton, M. Lawton, R. Higashida, W. S. Smith, W. L. Young, and D. Saloner. Aneurysm growth occurs at region of low wall shear stress. Stroke 39(11):2997–3002, 2008.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Brookshier, K. A., and J. M. Tarbell. Evaluation of a transparent blood analog fluid: aqueous xanthan gum/glycerin. Biorheology 30(2):107–116, 1993.

    Article  CAS  PubMed  Google Scholar 

  6. Cattaneo, G. F. M., A. Ding, T. Jost, D. Ley, R. Mühl-Bennighaus, U. Yilmaz, H. Körner, W. Reith, and A. Simgen. In vitro, contrast agent-based evaluation of the influence of flow diverter size and position on intra-aneurysmal flow dynamics using syngo iFlow. Neuroradiology 59(12):1275–1283, 2017.

    Article  PubMed  Google Scholar 

  7. Cebral, J. R., F. Mut, M. Raschi, S. Hodis, Y.-H. Ding, B. J. Erickson, R. Kadirvel, and D. F. Kallmes. Analysis of hemodynamics and aneurysm occlusion after flow-diverting treatment in rabbit models. Am. J. Neuroradiol. 35(8):1567–1573, 2014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Cebral, J. R., F. Mut, M. Raschi, E. Scrivano, R. Ceratto, P. Lylyk, and C. M. Putman. Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatment. Am. J. Neuroradiol. 32(1):27–33, 2011.

    Article  CAS  PubMed  Google Scholar 

  9. Dorn, F., F. Niedermeyer, A. Balasso, D. Liepsch, and T. Liebig. The effect of stents on intra-aneurysmal hemodynamics: in vitro evaluation of a pulsatile sidewall aneurysm using laser Doppler anemometry. Neuroradiology 53(4):267–272, 2011.

    Article  PubMed  Google Scholar 

  10. Evans, R. L., R. B. Kirkwood, and D. G. Opsahl. The dynamic viscosity of some human blood. Biorheology 8(3–4):125–128, 1971.

    Article  CAS  PubMed  Google Scholar 

  11. Gester, K., I. Lüchtefeld, M. Büsen, S. J. Sonntag, T. Linde, U. Steinseifer, and G. Cattaneo. In vitro evaluation of intra-aneurysmal, flow-diverter-induced thrombus formation: a feasibility study. Am. J. Neuroradiol. 37(3):490–496, 2016.

    Article  CAS  PubMed  Google Scholar 

  12. Jansen, S. V., I. Müller, M. Nachtsheim, T. Schmitz-Rode, and U. Steinseifer. Ghost cell suspensions as blood analogue fluid for macroscopic particle image velocimetry measurements. Artif. Organs 40(2):207–212, 2016.

    Article  CAS  PubMed  Google Scholar 

  13. Ley, D., R. Mühl-Benninghaus, U. Yilmaz, H. Körner, G. F. M. Cattaneo, W. Mailänder, Y. J. Kim, B. Scheller, W. Reith, and A. Simgen. The Derivo embolization device, a second-generation flow diverter for the treatment of intracranial aneurysms, evaluated in an elastase-induced aneurysm model. Clin. Neuroradiol. 27(3):335–343, 2015.

    Article  PubMed  Google Scholar 

  14. Lieber, B. B., V. Livescu, L. N. Hopkins, and A. K. Wakhloo. Particle image velocimetry assessment of stent design influence on intra-aneurysmal flow. Ann. Biomed. Eng. 30(6):768–777, 2002.

    Article  PubMed  Google Scholar 

  15. Liou, T.-M., S.-N. Liou, and K.-L. Chu. Intra-aneurysmal flow with helix and mesh stent placement across side-wall aneurysm pore of a straight parent vessel. J. Biomech. Eng. 126(1):36–43, 2004.

    Article  PubMed  Google Scholar 

  16. Perlo, J., E. V. Silletta, E. Danieli, G. Cattaneo, R. H. Acosta, B. Blümich, and F. Casanova. Desktop MRI as a promising tool for mapping intra-aneurismal flow. Magn. Reson. Imaging 33(3):328–335, 2015.

    Article  PubMed  Google Scholar 

  17. Pumar, J. M., A. Banguero, H. Cuellar, L. Guimaraens, J. Masso, S. Miralbes, M. Blanco-Ulla, F. Vazquez-Herrero, M. Souto, and M. Gelabert-Gonzalez. Treatment of intracranial aneurysms with the SILK embolization device in a multicenter study. A retrospective data analysis. Neurosurgery 81(4):595–601, 2017.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Rayz, V. L., L. Boussel, L. Ge, J. R. Leach, A. J. Martin, M. T. Lawton, C. McCulloch, and D. Saloner. Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms. Ann. Biomed. Eng. 38(10):3058–3069, 2010.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Rudin, S., Z. Wang, I. Kyprianou, K. R. Hoffmann, Y. Wu, H. Meng, L. R. Guterman, B. Nemes, D. R. Bednarek, and J. Dmochowski. Measurement of flow modification in phantom aneurysm model: comparison of coils and a longitudinally and axially asymmetric stent—initial findings. Radiology 231(1):272–276, 2004.

    Article  PubMed  Google Scholar 

  20. Shojima, M., M. Oshima, K. Takagi, R. Torii, M. Hayakawa, K. Katada, A. Morita, and T. Kirino. Magnitude and role of wall shear stress on cerebral aneurysm. Stroke 35(11):2500–2505, 2004.

    Article  PubMed  Google Scholar 

  21. Xiang, J., S. K. Natarajan, M. Tremmel, D. Ma, J. Mocco, L. N. Hopkins, A. H. Siddiqui, E. I. Levy, and H. Meng. Hemodynamic–morphologic discriminants for intracranial aneurysm rupture. Stroke 42(1):144–152, 2011.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the German Federal Ministry for Economic Affairs and Energy, Grant No. KF2335806AJ4. The authors thank the Department of Biochemical Engineering of the Aachener VerfahrensTechnik (AVT) Institute for the use of the rheometer.

Author information

Authors and Affiliations

  1. Department of Cardiovascular Engineering, Helmholtz Institute of Applied Medical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074, Aachen, Germany

    Johanna Clauser, Marius S. Knieps, Martin Büsen, Thomas Schmitz-Rode, Ulrich Steinseifer & Jutta Arens

  2. Acandis GmbH, Theodor-Fahrner-Straße 6, 75177, Pforzheim, Germany

    Andreas Ding & Giorgio Cattaneo

  3. Department of Mechanical and Aerospace Engineering, Faculty of Engineering, Monash Institute of Medical Engineering, Monash University, Melbourne, Australia

    Ulrich Steinseifer

Authors
  1. Johanna Clauser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marius S. Knieps
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Martin Büsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andreas Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Thomas Schmitz-Rode
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ulrich Steinseifer
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jutta Arens
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Giorgio Cattaneo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Giorgio Cattaneo.

Additional information

Associate Editor Sriram Neelamegham oversaw the review of this article.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (AVI 2176 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Clauser, J., Knieps, M.S., Büsen, M. et al. A Novel Plasma-Based Fluid for Particle Image Velocimetry (PIV): In-Vitro Feasibility Study of Flow Diverter Effects in Aneurysm Model. Ann Biomed Eng 46, 841–848 (2018). https://doi.org/10.1007/s10439-018-2002-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10439-018-2002-1

Keywords

Search

Navigation