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Sonomicrometry-Based Analysis of Post-Myocardial Infarction Regional Mechanics

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Abstract

Following myocardial infarction (MI), detrimental changes to the geometry, composition, and mechanical properties of the left ventricle (LV) are initiated in a process generally termed adverse post-MI remodeling. Cumulatively, these changes lead to a loss of LV function and are deterministic factors in the progression to heart failure. Proposed therapeutic strategies to target aberrant LV mechanics post-MI have shown potential to stabilize LV functional indices throughout the remodeling process. The in vivo quantification of LV mechanics, particularly within the MI region, is therefore essential to the continued development and evaluation of strategies to interrupt the post-MI remodeling process. The present study utilizes a porcine MI model and in vivo sonomicrometry to characterize MI region stiffness at 14 days post-MI. Obtained results demonstrate a significant dependence of mechanical properties on location and direction within the MI region, as well as cardiac phase. While approaches for comprehensive characterization of LV mechanics post-MI still need to be improved and standardized, our findings provide insight into the issues and complexities that must be considered within the MI region itself.

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References

  1. Akaishi, M., W. S. Weintraub, R. M. Schneider, L. W. Klein, J. B. Agarwal, and R. H. Helfant. Analysis of systolic bulging. Mechanical characteristics of acutely ischemic myocardium in the conscious dog. Circ. Res. 58:209–217, 1986.

    Article  CAS  PubMed  Google Scholar 

  2. Amundsen, B. H., T. Helle-Valle, T. Edvardsen, H. Torp, J. Crosby, E. Lyseggen, A. Støylen, H. Ihlen, J. A. C. Lima, O. A. Smiseth, and S. A. Slørdahl. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J. Am. Coll. Cardiol. 47:789–793, 2006.

    Article  PubMed  Google Scholar 

  3. Andreu, I., T. Luque, A. Sancho, B. Pelacho, O. Iglesias-García, E. Melo, R. Farré, F. Prósper, M. R. Elizalde, and D. Navajas. Heterogeneous micromechanical properties of the extracellular matrix in healthy and infarcted hearts. Acta Biomater. 10:3235–3242, 2014.

    Article  CAS  PubMed  Google Scholar 

  4. Bachner-Hinenzon, N., O. Ertracht, A. Malka, M. Leitman, Z. Vered, O. Binah, and D. Adam. Layer-specific strain analysis: investigation of regional deformations in a rat model of acute versus chronic myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 303:H549–H558, 2012.

    Article  CAS  PubMed  Google Scholar 

  5. Bhan, A., A. Sirker, J. Zhang, A. Protti, N. Catibog, W. Driver, R. Botnar, M. J. Monaghan, and A. M. Shah. High-frequency speckle tracking echocardiography in the assessment of left ventricular function and remodeling after murine myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 306:H1371–H1383, 2014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Capasso, J. M., P. Li, X. Zhang, and P. Anversa. Heterogeneity of ventricular remodeling myocardial infarction in rats after acute. Am. J. Physiol. Hear. Circ. Physiol. 262:H486–H495, 1992.

    CAS  Google Scholar 

  7. Cleutjens, J. P., M. J. Verluyten, J. F. Smiths, and M. J. Daemen. Collagen remodeling after myocardial infarction in the rat heart. Am. J. Pathol. 147:325–338, 1995.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Cohn, J. N., R. Ferrari, N. Sharpe, and I. Forum. Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. J. Am. Coll. Cardiol. 35(3):569–582, 2000.

    Article  CAS  PubMed  Google Scholar 

  9. Demer, L. L., and F. C. P. Yin. Passive biaxial mechanical properties of isolated canine myocardium. J. Physiol. 339:615–630, 1983.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Dhooge, J., A. Heimdal, F. Jamal, T. Kukulski, B. Bijnens, F. Rademakers, L. Hatle, P. Suetens, and G. R. Sutherland. Regional strain and strain rate measurements by cardiac ultrasound: principles, implementation and limitations. Eur. J. Echocardiogr. 1:154–170, 2000.

    Article  CAS  Google Scholar 

  11. Dione, D., P. Shi, W. Smith, P. Deman, J. Soares, J. Duncan, and A. Sinusas. Three-Dimensional Regional Left Ventricular Deformation from Digital Sonomicrometry. In 19th International Conference IEEE/EMBS, pp. 848–851, 1999.

  12. Dobaczewski, M., M. Bujak, P. Zymek, G. Ren, M. L. Entman, and N. G. Frangogiannis. Extracellular matrix remodeling in canine and mouse myocardial infarcts. Cell Tissue Res. 324:475–488, 2006.

    Article  CAS  PubMed  Google Scholar 

  13. Dobaczewski, M., C. Gonzalez-Quesada, and N. G. Frangogiannis. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J. Mol. Cell. Cardiol. 48:504–511, 2010.

    Article  CAS  PubMed  Google Scholar 

  14. Eaton, L. W., J. L. Weiss, B. H. Bulkley, J. B. Garrison, and M. L. Weisfeldt. Regional Cardiac Dilatation after Acute Myocardial Infarction—NEJM, 1979. http://www.nejm.org/doi/pdf/10.1056/NEJM197901113000202.

  15. Eckhouse, S. R., B. P. Purcell, J. R. McGarvey, D. Lobb, C. B. Logdon, H. Doviak, J. W. O’Neill, J. A. Shuman, C. P. Novack, K. N. Zellars, S. Pettaway, R. A. Black, A. Khakoo, T. Lee, R. Mukherjee, J. H. Gorman, R. C. Gorman, J. A. Burdick, and F. G. Spinale. Local hydrogel release of recombinant TIMP-3 attenuates adverse left ventricular remodeling after experimental myocardial infarction. Sci. Transl. Med. 6(223):223ra21, 2014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Fomovsky, G. M., and J. W. Holmes. Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat. Am. J. Physiol. Heart Circ. Physiol. 298:H221–H228, 2010.

    Article  CAS  PubMed  Google Scholar 

  17. Fomovsky, G. M., A. D. Rouillard, and J. W. Holmes. Regional mechanics determine collagen fiber structure in healing myocardial infarcts. J. Mol. Cell. Cardiol. 52:1083–1090, 2012.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Fujimoto, K. L., Z. Ma, D. M. Nelson, R. Hashizume, J. Guan, K. Tobita, and W. R. Wagner. Biomaterials Synthesis, characterization and therapeutic efficacy of a biodegradable, thermoresponsive hydrogel designed for application in chronic infarcted myocardium. Biomaterials 30:4357–4368, 2009.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Go, A. S., et al. Heart disease and stroke statistics–2013 update: a report from the American Heart Association. Circulation 127:e6–e245, 2013.

    Article  PubMed  Google Scholar 

  20. Go, A. S., et al. Heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation 129:e28–e292, 2014.

    Article  PubMed  Google Scholar 

  21. Gorman, J. H., K. B. Gupta, J. T. Streicher, R. C. Gorman, B. M. Jackson, M. B. Ratcliffe, D. K. Bogen, and L. H. Edmunds. Dynamic three-dimensional imaging of the mitral valve and left ventricle by rapid sonomicrometry array localization. J. Thorac. Cardiovasc. Surg. 112:712–726, 1996.

    Article  PubMed  Google Scholar 

  22. Gupta, K. B., M. B. Ratcliffe, M. A. Fallert, L. H. Edmunds, and D. K. Bogen. Changes in passive mechanical stiffness of myocardial tissue with aneurysm formation. Circulation 89:2315–2326, 1994.

    Article  CAS  PubMed  Google Scholar 

  23. Helle-valle, T., E. W. Remme, E. Lyseggen, E. Pettersen, T. Vartdal, A. Opdahl, H. Smith, N. F. Osman, H. Ihlen, T. Edvardsen, and O. A. Smiseth. Clinical assessment of left ventricular rotation and strain: a novel approach for quantification of function in infarcted myocardium and its border zones. Am. J. Physiol. Heart Circ. Physiol. 297(1):H257–H267, 2009. doi:10.1152/ajpheart.01116.2008.

    Article  CAS  PubMed  Google Scholar 

  24. Holmes, J. W., T. K. Borg, and J. W. Covell. Structure and mechanics of healing myocardial infarcts. Annu. Rev. Biomed. Eng. 7:223–253, 2005.

    Article  CAS  PubMed  Google Scholar 

  25. Holmes, J. W., J. A. Nunez, and J. W. Covell. Functional implications of myocardial scar structure. Am. J. Physiol. Heart Circ. Physiol. 272:H2123–H2130, 1997.

    CAS  Google Scholar 

  26. Holmes, J. W., H. Yamashita, L. K. Waldman, and J. W. Covell. Scar remodeling and transmural deformation after infarction in the pig. Circulation 90:411–420, 1994.

    Article  CAS  PubMed  Google Scholar 

  27. Holzapfel, G. A., and R. W. Ogden. Constitutive modelling of passive myocardium: a structurally based framework for material characterization. Philos. Trans. A. Math. Phys. Eng. Sci. 367:3445–3475, 2009.

    Article  PubMed  Google Scholar 

  28. Humphrey, J. D. Continuum biomechanics of soft biological tissues. Proc. R. Soc. Lond. A 459:3–46, 2003.

    Article  Google Scholar 

  29. Jackson, B. M., J. H. Gorman, III, S. L. Moainie, T. S. Guy, N. Narula, J. Narula, M. G. S. John-Sutton, L. H. Edmunds, Jr, and R. C. Gorman. Extension of borderzone myocardium in postinfarction dilated cardiomyopathy. J. Am. Coll. Cardiol. 40(6):1160–1167, 2002.

    Article  PubMed  Google Scholar 

  30. Jugdutt, B. I. Prevention of ventricular remodeling after myocardial infarction and in congestive heart failure. Heart Fail. Rev. 1:115–129, 1996.

    Article  Google Scholar 

  31. Jugdutt, B. I. Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways. Curr. Drug Targets Cardiovasc. Haematol. Disord. 3(1):1–30, 2003.

    Article  CAS  PubMed  Google Scholar 

  32. Jugdutt, B. I. Cyclooxygenase inhibition and adverse remodeling during healing after myocardial infarction. Circulation 115:288–291, 2007.

    Article  PubMed  Google Scholar 

  33. Jugdutt, B. I., M. J. Joljart, and M. I. Khan. Rate of collagen deposition during healing and ventricular remodeling after myocardial infarction in rat and dog models. Circulation 94:94–101, 1996.

    Article  CAS  PubMed  Google Scholar 

  34. Kellar, R. S., B. R. Shepherd, D. F. Larson, G. K. Naughton, and S. K. Williams. Cardiac patch constructed from human fibroblasts attenuates reduction in cardiac function after acute infarct. Tissue Eng. 11:1678–1687, 2005.

    Article  CAS  PubMed  Google Scholar 

  35. Kelley, S. T., R. Malekan, J. H. Gorman, III, B. M. Jackson, C. Robert, Y. Suzuki, T. Plappert, D. K. Bogen, M. G. Sutton, and L. H. Edmunds, Jr. Restraining infarct expansion preserves left ventricular geometry and function after acute anteroapical infarction. Circulation 99:135–142, 1999.

    Article  CAS  PubMed  Google Scholar 

  36. Klepach, D., L. C. Lee, J. F. Wenk, M. B. Ratcliffe, T. I. Zohdi, J. A. Navia, G. S. Kassab, E. Kuhl, and J. M. Guccione. Growth and remodeling of the left ventricle: a case study of myocardial infarction and surgical ventricular restoration. Mech. Res. Commun. 42:134–141, 2012.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Korinek, J., J. Vitek, P. P. Sengupta, A. Romero-Corral, V. K. Krishnamoorthy, E. M. McMahon, B. K. Khandheria, and M. Belohlavek. Does implantation of sonomicrometry crystals alter regional cardiac muscle function? J. Am. Soc. Echocardiogr. 20:1407–1412, 2007.

    Article  PubMed  Google Scholar 

  38. Korinek, J., J. Wang, P. P. Sengupta, C. Miyazaki, J. Kjaergaard, E. McMahon, T. P. Abraham, and M. Belohlavek. Two-dimensional strain—a Doppler-independent ultrasound method for quantitation of regional deformation: validation in vitro and in vivo. J. Am. Soc. Echocardiogr. 18:1247–1253, 2005.

    Article  PubMed  Google Scholar 

  39. Kraitchman, D. L., A. A. Young, D. C. Bloomgarden, Z. A. Fayad, L. Dougherty, V. A. Ferrari, R. C. Boston, and L. Axel. Integrated MRI assessment of regional function and perfusion in canine myocardial infarction. Magn. Reson. Med. 40:311–326, 1998.

    Article  CAS  PubMed  Google Scholar 

  40. Leor, J., S. Aboulafia-Etzion, A. Dar, L. Shapiro, I. M. Barbash, A. Battler, Y. Granot, and S. Cohen. Bioengineering cardiac grafts: a new approach to repair the infarcted myocardium? Circulation 102(19 Suppl 3):III56–III61, 2000. doi:10.1161/01.CIR.102.suppl.

    CAS  PubMed  Google Scholar 

  41. Leor, J., and S. Cohen. Myocardial tissue engineering: creating a muscle patch for a wounded heart. Ann. N.Y. Acad. Sci. 1015:312–319, 2004.

    Article  PubMed  Google Scholar 

  42. MacKenna, D., S. R. Summerour, and F. J. Villarreal. Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis. Cardiovasc. Res. 46:257–263, 2000.

    Article  CAS  PubMed  Google Scholar 

  43. Marinkovid, J., J. Lee, M. Tan, and J. D. Thomas. Serial assessment of left ventricular chamber stiffness after acute myocardial infarction. Am. J. Cardiol. 77:361–364, 1995.

    Google Scholar 

  44. McKay, R. G., M. A. Pfeffer, R. C. Pasternak, J. E. Markis, P. C. Come, S. Nakao, J. D. Alderman, J. J. Ferguson, R. D. Safian, and W. Grossman. Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion. Circulation 74:693–702, 1986.

    Article  CAS  PubMed  Google Scholar 

  45. Mojsejenko, D., J. R. McGarvey, S. M. Dorsey, J. H. Gorman, III, J. A. Burdick, J. J. Pilla, R. C. Gorman, and J. F. Wenk. Estimating passive mechanical properties in a myocardial infarction using MRI and finite element simulations. Biomech. Model. Mechanobiol. 14(3):633–647, 2014.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Morita, M., C. E. Eckert, K. Matsuzaki, M. Noma, L. P. Ryan, J. A. Burdick, B. M. Jackson, J. H. Gorman, III, M. S. Sacks, and R. C. Gorman. Modification of infarct material properties limits. Ann. Thorac. Surg. 92:617–624, 2011.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Mukherjee, R., T. A. Brinsa, K. B. Dowdy, A. A. Scott, J. M. Baskin, A. M. Deschamps, A. S. Lowry, G. P. Escobar, D. G. Lucas, W. M. Yarbrough, M. R. Zile, and F. G. Spinale. Myocardial infarct expansion and matrix metalloproteinase inhibition. Circulation 107:618–625, 2003.

    Article  CAS  PubMed  Google Scholar 

  48. Neidlinger-Wilke, C., E. S. Grood, J. H. C. Wang, R. A. Brand, and L. Claes. Cell alignment is induced by cyclic changes in cell length: studies of cells grown in cyclically stretched substrates. J. Orthop. Res. 19:286–293, 2001.

    Article  CAS  PubMed  Google Scholar 

  49. Olivetti, G., J. M. Capasso, L. G. Meggs, E. H. Sonnenblick, and P. Anversa. Cellular basis of chronic ventricular remodeling after myocardial infarction in rats. Circ. Res. 68:856–869, 1991.

    Article  CAS  PubMed  Google Scholar 

  50. Omens, J. H., T. R. Miller, and J. W. Covell. Relationship between passive tissue strain and collagen uncoiling during healing of infarcted myocardium. Cardiovasc. Res. 33:351–358, 1997.

    Article  CAS  PubMed  Google Scholar 

  51. Pang, Y., X. Wang, D. Lee, and H. P. Greisler. Dynamic quantitative visualization of single cell alignment and migration and matrix remodeling in 3-D collagen hydrogels under mechanical force. Biomaterials 32:3776–3783, 2011.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Park, T., S. F. Nagueh, D. S. Khoury, H. A. Kopelen, S. Akrivakis, K. Nasser, G. Ren, N. G. Frangogiannis, and A. Helen. Impact of myocardial structure and function postinfarction on diastolic strain measurements: implications for assessment of myocardial viability. Am. J. Physiol. Heart Circ. Physiol. 77030:724–731, 2006.

    Google Scholar 

  53. Périé, D., N. Dahdah, A. Foudis, and D. Curnier. Multi-parametric MRI as an indirect evaluation tool of the mechanical properties of in vitro cardiac tissues. BMC Cardiovasc. Disord. 13:24, 2013.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Pfeffer, M. A., and E. Braunwald. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 81:1161–1172, 1990.

    Article  CAS  PubMed  Google Scholar 

  55. Pfeffer, M. A., E. Braunwald, L. A. Moye, L. Basta, E. J. Brown, Jr, T. E. Cuddy, B. R. Davis, and E. M. Geltman. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial. N. Engl. J. Med. 327:669–677, 1992.

    Article  CAS  PubMed  Google Scholar 

  56. Pfeffer, M. A., J. M. Pfeffer, M. C. Fishbein, P. J. Fletcher, J. Spadaro, R. A. Kloner, and E. Braunwald. Myocardial infarct size and ventricular function in rats. Circ. Res. 44:503–512, 1979.

    Article  CAS  PubMed  Google Scholar 

  57. Pilla, J. J., J. H. Gorman, and R. C. Gorman. Theoretic impact of infarct compliance on left ventricular function. Ann. Thorac. Surg. 87:803–810, 2009.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Purcell, B. P., D. Lobb, M. B. Charati, S. M. Dorsey, R. J. Wade, K. N. Zellars, H. Doviak, S. Pettaway, C. B. Logdon, J. A. Shuman, P. D. Freels, J. H. Gorman, R. C. Gorman, F. G. Spinale, and J. A. Burdick. Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition. Nat. Mater. 13:653–661, 2014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Roberts, C. S., D. Maclean, P. Maroko, and R. A. Kloner. Early and late remodeling of the left ventricle after acute myocardial infarction. Am. J. Cardiol. 54:407–410, 1984.

    Article  CAS  PubMed  Google Scholar 

  60. Ross, A. J., Z. Yang, S. S. Berr, W. D. Gilson, W. C. Petersen, J. N. Oshinski, and B. A. French. Serial MRI evaluation of cardiac structure and function in mice after reperfused myocardial infarction. Magn. Reson. Med. 47:1158–1168, 2002.

    Article  PubMed  Google Scholar 

  61. Ryan, L. P., K. Matsuzaki, M. Noma, B. M. Jackson, T. J. Eperjesi, T. J. Plappert, M. G. S. John-Sutton, J. H. Gorman, III, and R. C. Gorman. Dermal filler injection: a novel approach for limiting infarct expansion. Ann. Thorac. Surg. 87:148–155, 2009.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Sacks, M. S., and W. Sun. Multiaxial mechanical behavior of biological materials. Annu. Rev. Biomed. Eng. 5:251–284, 2003.

    Article  CAS  PubMed  Google Scholar 

  63. Schmidt, A., C. F. Azevedo, A. Cheng, S. N. Gupta, D. A. Bluemke, T. K. Foo, G. Gerstenblith, R. G. Weiss, E. Marbán, G. F. Tomaselli, J. A. C. Lima, and K. C. Wu. Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation 115:2006–2014, 2007.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Selvaraj, S., F. G. Aguilar, E. E. Martinez, L. Beussink, K.-Y. A. Kim, J. Peng, D. C. Lee, A. Patel, J. Sha, M. R. Irvin, D. K. Arnett, and S. J. Shah. Diastolic wall strain: a simple marker of abnormal cardiac mechanics. Cardiovasc. Ultrasound 12:40, 2014.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Singelyn, J. M., P. Sundaramurthy, T. D. Johnson, P. J. Schup-Magoffin, D. P. Hu, D. M. Faulk, J. Wang, K. M. Mayle, K. Bartels, M. Salvatore, A. M. Kinsey, A. N. Demaria, N. Dib, and K. L. Christman. Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. J. Am. Coll. Cardiol. 59:751–763, 2012.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Soleimanifard, S., K. Z. Abd-Elmoniem, T. Sasano, H. K. Agarwal, M. R. Abraham, T. P. Abraham, and J. L. Prince. Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study. J. Cardiovasc. Magn. Reson. 14:85, 2012.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Spinale, F. G., M. L. Coker, S. R. Krombach, R. Mukherjee, H. Hallak, W. V. Houck, M. J. Clair, S. B. Kribbs, L. L. Johnson, J. T. Peterson, and M. R. Zile. Matrix metalloproteinase inhibition during the development of congestive heart failure: effects on left ventricular dimensions and function. Circ. Res. 85:364–376, 1999.

    Article  CAS  PubMed  Google Scholar 

  68. Sun, Y., and K. T. Weber. Infarct scar: a dynamic tissue. Cardiovasc. Res. 46:250–256, 2000.

    Article  CAS  PubMed  Google Scholar 

  69. Sutton, M. G., and N. Sharpe. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 101:2981–2988, 2000.

    Article  CAS  PubMed  Google Scholar 

  70. Takahashi, T., M. J. Levine, and W. Grossman. Regional diastolic mechanics of ischemic and nonischemic myocardium in the pig heart. J. Am. Coll. Cardiol. 17:1203–1212, 1991.

    Article  CAS  PubMed  Google Scholar 

  71. Theroux, P., J. Ross, D. Franklin, J. W. Covell, C. M. Bloor, and S. Sasayama. Regional myocardial function and dimensions early and late after myocardial infarction in the unanesthetized dog. Circ. Res. 40:158–165, 1977.

    Article  CAS  PubMed  Google Scholar 

  72. Thomopoulos, S., G. M. Fomovsky, and J. W. Holmes. The development of structural and mechanical anisotropy in fibroblast populated collagen gels. J. Biomech. Eng. 127:742, 2005.

    Article  PubMed  Google Scholar 

  73. Thorstensen, A., B. H. Amundsen, H. Dalen, P. Hala, G. Kiss, S. A. Aase, H. Torp, and A. Støylen. Strain rate imaging combined with wall motion analysis gives incremental value in direct quantification of myocardial infarct size. Eur. Heart J. Cardiovasc. Imaging 13:914–921, 2012.

    Article  PubMed  Google Scholar 

  74. Thygesen, K., et al. Third universal definition of myocardial infarction. J. Am. Coll. Cardiol. 60:1581–1598, 2012.

    Article  PubMed  Google Scholar 

  75. Urheim, S., T. Edvardsen, K. Steine, H. Skulstad, E. Lyseggen, O. Rodevand, O. A. Smiseth, and A. Otto. Postsystolic shortening of ischemic myocardium: a mechanism of abnormal intraventricular filling. Am. J. Physiol. Heart Circ. Physiol. 284(6):H2343–H2350, 2003.

    Article  CAS  PubMed  Google Scholar 

  76. Urheim, S., T. Edvardsen, H. Torp, B. Angelsen, and O. A. Smiseth. Myocardial strain by Doppler echocardiography: validation of a new method to quantify regional myocardial function. Circulation 102:1158–1164, 2000.

    Article  CAS  PubMed  Google Scholar 

  77. Weisman, H. F., D. E. Bush, J. A. Mannisi, and B. H. Bulkley. Global cardiac remodeling after acute myocardial infarction: a study in the rat model. J. Am. Coll. Cardiol. 5:1355–1362, 1985.

    Article  CAS  PubMed  Google Scholar 

  78. Weisman, H. F., D. E. Bush, J. A. Mannisi, M. L. Weisfeldt, and B. Healy. Cellular mechanisms of myocardial infarct expansion. Circulation 78:186–201, 1988.

    Article  CAS  PubMed  Google Scholar 

  79. Whittaker, P., D. R. Boughner, and R. A. Kloner. Role of collagen in acute myocardial infarct expansion. Circulation 84:2123–2134, 1991.

    Article  CAS  PubMed  Google Scholar 

  80. Whittaker, P., R. A. Kloner, D. R. Boughner, and J. G. Pickering. Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light. Basic Res. Cardiol. 89(5):397–410, 1994.

    Article  CAS  PubMed  Google Scholar 

  81. Yarbrough, W. M., R. Mukherjee, T. A. Brinsa, K. B. Dowdy, A. A. Scott, G. P. Escobar, C. Joffs, D. G. Lucas, F. A. Crawford, and F. G. Spinale. Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs. J. Thorac. Cardiovasc. Surg. 125:602–610, 2003.

    Article  PubMed  Google Scholar 

  82. Yeon, S. B., N. Reichek, B. A. Tallant, J. A. Lima, L. P. Calhoun, N. R. Clark, E. A. Hoffman, K. K. Ho, and L. Axel. Validation of in vivo myocardial strain measurement by magnetic resonance tagging with sonomicrometry. J. Am. Coll. Cardiol. 38:555–561, 2001.

    Article  CAS  PubMed  Google Scholar 

  83. Yin, F. C., R. K. Strumpf, P. H. Chew, and S. L. Zeger. Quantification of the mechanical properties of noncontracting canine myocardium under simultaneous biaxial loading. J. Biomech. 20(6):577–589, 1987.

    Article  CAS  PubMed  Google Scholar 

  84. Zhang, Y., A. K. Y. Chan, C.-M. Yu, G. W. K. Yip, J. W. H. Fung, W. W. M. Lam, N. M. C. So, M. Wang, E. B. Wu, J. T. Wong, and J. E. Sanderson. Strain rate imaging differentiates transmural from non-transmural myocardial infarction: a validation study using delayed-enhancement magnetic resonance imaging. J. Am. Coll. Cardiol. 46:864–871, 2005.

    Article  PubMed  Google Scholar 

  85. Zhang, Z., D. Dione, B. A. Lin, J. S. Duncan, A. J. Sinusas, and S. Sampath. Early diastolic function observed in canine model of reperfused transmural myocardial infarction using high temporal resolution MR imaging. J. Cardiovasc. Magn. Reson. 14:W65, 2012.

    Article  PubMed Central  Google Scholar 

  86. Zimmerman, S. D., W. J. Karlon, J. W. Holmes, J. H. Omens, and J. W. Covell. Structural and mechanical factors influencing infarct scar collagen organization Structural and mechanical factors influencing infarct scar collagen organization. Am. J. Physiol. Heart Circ. Physiol. 278:H194–H200, 2000.

    CAS  PubMed  Google Scholar 

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Acknowledgments

Figure 1 was generated by Dr. Adam Hartstone-Rose in the Department of Cell Biology and Anatomy at the University of South Carolina School of Medicine. This work was supported by the National Institute of Health grants HL11090, HL089944, HL43617, HL67922, and Merit Award from the Veterans’ Affairs Health Administration. The authors wish to express their sincere appreciation to Ashley Sapp for her editorial assistance.

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Authors and Affiliations

  1. University of South Carolina College of Engineering and Computing, Columbia, USA

    Eva Romito, Tarek Shazly & Francis G. Spinale

  2. Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, USA

    Eva Romito, Heather Doviak, Christina Logdon, Parker Freels & Francis G. Spinale

  3. Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, USA

    Heather Doviak, Christina Logdon & Francis G. Spinale

  4. WJB Dorn Veteran Affairs Medical Center, Columbia, SC, USA

    Francis G. Spinale

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  1. Eva Romito
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  2. Heather Doviak
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  3. Christina Logdon
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  4. Parker Freels
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  5. Tarek Shazly
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  6. Francis G. Spinale
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Correspondence to Tarek Shazly.

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Associate Editor Karyn Kunzelman oversaw the review of this article.

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Romito, E., Doviak, H., Logdon, C. et al. Sonomicrometry-Based Analysis of Post-Myocardial Infarction Regional Mechanics. Ann Biomed Eng 44, 3539–3552 (2016). https://doi.org/10.1007/s10439-016-1694-3

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  • DOI: https://doi.org/10.1007/s10439-016-1694-3

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