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Finite Element Modeling of Mitral Valve Dynamic Deformation Using Patient-Specific Multi-Slices Computed Tomography Scans

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Abstract

The objective of this study was to develop a patient-specific finite element (FE) model of a human mitral valve. The geometry of the mitral valve was reconstructed from multi-slice computed tomography (MSCT) scans at middle diastole with distinguishable mitral leaflet thickness, chordal origins, chordal insertion points, and papillary muscle locations. Mitral annulus and papillary muscle dynamic motions were also quantified from MSCT scans and prescribed as boundary conditions for the FE simulation. Material properties of the human mitral leaflet tissues were obtained from biaxial tests and characterized by an anisotropic hyperelastic material model. In vivo dynamic closing of the mitral valve was simulated. The closed shape of the mitral valve output from the simulation was similar to the mitral valve geometry reconstructed from MSCT images at middle systole. Forces from the anterolateral and posteromedial papillary muscle groups at middle systole were 4.51 N and 5.17 N, respectively. The average maximum principal stress of the midsection of the anterior mitral leaflet was approximately 160 kPa at the systolic peak. Results demonstrated that the developed FE model could closely replicate in vivo mitral valve dynamic motion during middle diastole and systole. This model may serve as a basis for utilizing computational simulations to obtain a better understanding of mitral valve mechanics, disease and surgical repair.

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Acknowledgments

This work was supported in part by the AHA SDG grant 0930319N. We would like to thank Dr. Charles Primiano and Dr. Raymond McKay at the Hartford Hospital, CT for providing the image data. We would also like to thank our lab member Thuy Pham for providing experimental data of the mitral tissues.

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Authors and Affiliations

  1. Tissue Mechanics Laboratory, Biomedical Engineering Program and Mechanical Engineering Department, University of Connecticut, 207 Bronwell Building, Storrs, CT, 06269-3139, USA

    Qian Wang & Wei Sun

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  1. Qian Wang
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  2. Wei Sun
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Correspondence to Wei Sun.

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Associate Editor Nathalie Virag oversaw the review of this article.

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Wang, Q., Sun, W. Finite Element Modeling of Mitral Valve Dynamic Deformation Using Patient-Specific Multi-Slices Computed Tomography Scans. Ann Biomed Eng 41, 142–153 (2013). https://doi.org/10.1007/s10439-012-0620-6

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  • DOI: https://doi.org/10.1007/s10439-012-0620-6

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