Abstract
Near-infrared spectroscopy provides useful biological information after the radiation has penetrated through the tissue, within the therapeutic window. One of the significant shortcomings of the current applications of spectroscopic techniques to a live subject is that the subject may be uncooperative and the sample undergoes significant temporal variations, due to his health status that, from radiometric point of view, introduce measurement noise. We describe a novel wavelength selection method for monitoring, based on a standard deviation map, that allows low-noise sensitivity. It may be used with spectral transillumination, transmission, or reflection signals, including those corrupted by noise and unavoidable temporal effects. We apply it to the selection of two wavelengths for the case of pulse oximetry. Using spectroscopic data, we generate a map of standard deviation that we propose as a figure-of-merit in the presence of the noise introduced by the living subject. Even in the presence of diverse sources of noise, we identify four wavelength domains with standard deviation, minimally sensitive to temporal noise, and two wavelengths domains with low sensitivity to temporal noise.
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Aldrich, T. K., M. Moosikasuwan, S. D. Shah, and K. S. Deshponde. Length-normalized pulse photoplethysmography: a noninvasive method to measure blood hemoglobin. Ann. Biomed. Eng. 30:1291–1298, 2002.
Aoyagi, T. Pulse oximetry its invention, theory, and future. J. Anesth. 17(4):259–266, 2003.
Aoyagi, T., M. Fuse, N. Kobayashi, K. Machida, and K. Miyasaka. Multi-wavelength pulse oximetry: theory for the future. Anesth. Analg. 105(6 Suppl):S53–S58, 2007.
Aoyagi, T., and K. Miyasaka. Pulse oximetry: its invention, contribution to medicine and future tasks. Anesth. Analg. 94:S1–S3, 2002.
Baker, C. Pulse oximeter with parallel saturation calculation modules. United State Patent, 20050124871 (2005).
Barker, S. J., J. Curry, D. Redford, and S. Morgan. Measurements or carboxyhemoglobin and methemoglobin by pulse oximetry: a human volunteer study. Anesthesiology 105:892–897, 2007.
Cannesson, M., and P. Talke. Recent advances in pulse oximetry. F1000 Med. Rep. 1:66, 2009.
Choi, J. H., M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton. Noninvasive determination of the optical properties of adult brain near-infrared spectroscopy approach. J. Biomed. Opt. 9(1):221–229, 2004.
Culver, J. P., A. M. Siegel, J. J. Stott, and D. A. Boas. Volumetric diffuse optical tomography of brain activity. Opt. Lett. 28(21):2061–2063, 2003.
Cysewska-Sobusiak, A. One-dimensional representation of light-tissue interaction for application in noninvasive oximetry. Opt. Eng. 36(4):1225–1233, 1997.
Desebbe, O., and M. Cannesson. Using ventilation induced plethysmographic variations to optimize patient fluid status. Curr. Opin. Anaesthesiol. 21:772–778, 2008.
Fantini, S., and M. A. Franceschini. Frequency-domain techniques for tissue spectroscopy and imaging. In: Handbook of Optical Biomedical Diagnostics, edited by V. V. Tuchin. Bellingham: SPIE Press, 2002.
Gratton, E., V. Toronov, U. Wolf, M. Wolf, and A. Webb. Measurement of brain activity by near-infrared light. J. Biomed. Opt. 10(1):8–13, 2005.
Hayes, M. J., and P. R. Smith. A new method for pulse oximetry possessing inherent insensitivity to artifact. IEEE Trans. Biomed. Eng. 48:452–461, 2001.
Humphreys, K., T. Ward, and C. Markham. Noncontact simultaneous dual wavelength photoplethysmography: a further step toward noncontact pulse oximetry. Rev. Sci. Instrum. 78(4):1–6, 2007.
Ignjatovic, N., M. Vasiljevic, D. Milic, J. Stefanovic, M. Stojanovic, A. Karanikolic, A. Zlatic, G. Djordjevic, S. Zivic, L. Jeremic, I. Djordjevic, and R. Jankovic. Diagnostic importance of pulse oximetry in the determination of the stage of chronic arterial insufficiency of lower extremities. Srp. Arh. Celok. Lek. 138(5–6):300–304, 2010.
Kurth, C. D., and W. Thayer. A multiwavelength frequency-domain near-infrared cerebral oximeter. Phys. Med. Biol. 44(3):727–740, 1999.
Liu, H., D. A. Boas, Y. Zhang, A. G. Yodh, and B. Chance. Determination of optical properties and blood oxygenation in tissue continuous NIR light. Phys. Med. Biol. 40(11):1983–1993, 1995.
Lopez-Silva, S. M., M. L. Dotor-Castilla, and J. P. Silveira-Martin. Near-infrared transmittance pulse oximetry with laser diodes. J. Biomed. Opt. 8(3):525–533, 2003.
Mannheimer, P. D., J. R. Casciani, M. E. Fein, and S. L. Nierlich. Wavelength selection for low saturation pulse oximetry. IEEE Trans. Biomed. Eng. 44(3):148–158, 1997.
Mobley, J., and T. Vo-Dinh. Light-tissue inter-actions. In: Biomedical Photonics Handbook, edited by T. Vo-Dinh. New York: CRC Press, 2003.
Nelson, L. A., J. C. McCann, A. W. Loepke, J. Wu, B. B. Dor, and C. D. Kurth. Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia. J. Biomed. Opt. 11(6):1–8, 2006.
Nitzan, M., A. Babchenko, B. Khanokh, and H. Taitelbaum. Measurement of oxygen saturation in venous blood by dynamic near infrared spectroscopy. J. Biomed. Opt. 5(2):155–162, 2000.
Nitzan, M., and E. Shlomo. Three-wavelength technique for the measurement of oxygen saturation in arterial blood and in venous blood. J. Biomed. Opt. 14(2):1–6, 2009.
Niwayama, M., L. Lin, J. Shao, N. Kudo, and K. Yamamoto. Quantitative measurement of muscle hemoglobin oxygenation using near-infrared spectroscopy with correction of the influence of a subcutaneous fat layer. Rev. Sci. Instrum. 71(12):4571–4575, 2000.
Paez G., C. Vazquez-Jaccaud, and M. Strojnik. Development of noise-immune oximetry: theory and measurement. In: Proc. SPIE 6307, 63070F, 2006.
Petterson, M. T., V. L. Begnoche, and J. M. Graybeal. The effect of motion on pulse oximetry and its clinical significance. Anesth. Analog. 105(6 Suppl):S78–S84, 2007.
Phillips, J. P., R. M. Langford, S. H. Chang, K. Maney, P. A. Kyriacou, and D. P. Jones. An oesophageal pulse oximetry system utilising a fiber-optic probe. J. Phys.: Conf. Ser. 178:012021, 2009.
Pittman, R. N. In vivo photometric analysis of hemoglobin. Ann. Biomed. Eng. 14:119–137, 1986.
Pogue, B. W., and M. S. Patterson. Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry. J. Biomed. Opt. 11(4):1–16, 2006.
Rice, J. A. Mathematical Statistics and Data Analysis (2nd ed.). Pacific Grove, CA: Duxburry Press, 1995.
Rothmaier, M., B. Selm, S. Spichtig, D. Haensse, and M. Wolf. Photonic textiles for pulse oximetry. Opt. Express 16(17):12973–12986, 2008.
Salyer, J. W. Neonatal and pediatric pulse oximetry. Respir. Care 48(4):386–396, 2003.
Sebald, D. J. Motivation of pulse oximetry. In: Design of Pulse Oximeters, edited by J. G. Webster. Bristol: IOP Publishing, 1997.
Shao, J., L. Lin, M. Niwayama, N. Kudo, and K. Yamamoto. Theoretical and experimental studies on linear and nonlinear algorithms for the measurement of muscle oxygenation using continuous-wave near-infrared spectroscopy. Opt. Eng. 40(10):2293–2301, 2001.
Shelley, K. H. Photoplethysmography: beyond the calculation of arterial oxygen saturation and heart rate. Anesth. Analg. 105:S31–S36, 2007.
Smith, M. H. Optimum wavelength combinations for retinal vessel oximetry. Appl. Opt. 38(1):258–267, 1999.
Strojnik, M., and G. Paez. Radiometry. In: Handbook of Optical Engineering, edited by D. Malacara, and B. Thompson. New York: Marcel Dekker, 2001.
Tromberg, B. J., B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi. Assessing the future of diffuse optical imaging technologies for breast cancer management. Med. Phys. 35(6):2443–2451, 2008.
Vacas-Jaques, P., G. Paez, and M. Strojnik. Pass-through photon-based biomedical transillumination. J. Biomed. Opt. 13(4):1–10, 2008.
Vazquez-Jaccaud, C., G. Paez, and M. Strojnik. Oximetry using a novel expression for oxygen saturation. In: AITA 2007 Proceedings, Leon, Mexico, 2008, pp. 451–457.
Wray, S., M. Cope, D. Delpy, J. Wyatt, and O. Reynolds. Characterization of the near infrared absorption spectra of cytochrome aa3 and hemoglobin for the non invasive monitoring of cerebral oxygenation. Biochim. Biophys. Acta 933:184–192, 1988.
Acknowledgments
Authors wish to acknowledge the financial support of CONACYT through the project: “Applications of infrared interferometry for biomedical tomography” (CONACYT 2007-I0003-60450). C. Vazquez-Jaccaud was a recipient of the CONACYT fellowship.
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Associate Editor Miklos Gratzl oversaw the review of this article.
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Vazquez-Jaccaud, C., Paez, G. & Strojnik, M. Wavelength Selection Method with Standard Deviation: Application to Pulse Oximetry. Ann Biomed Eng 39, 1994–2009 (2011). https://doi.org/10.1007/s10439-011-0304-7
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DOI: https://doi.org/10.1007/s10439-011-0304-7