A high resolution approach to estimating time-frequency spectra (TFS) and associated amplitudes via the use of variable frequency complex demodulation (VFCDM) is presented. This is a two-step procedure in which the previously developed time-varying optimal parameter search (TVOPS) technique is used to obtain TFS, followed by using the VFCDM to obtain even greater TFS resolution and instantaneous amplitudes associated with only the specific frequencies of interest. This combinational use of the TVOPS and the VFCDM is termed the TVOPS-VFCDM. Simulation examples are provided to demonstrate the performance of the TVOPS-VFCDM for high resolution TFS as well as instantaneous amplitude estimation. The simulation results show that the TVOPS-VFCDM approach provides the highest resolution and most accurate amplitude estimates when compared to the smoothed pseudo Wigner–Ville, continuous wavelet transform and Hilbert–Huang transform methods. Application of the TVOPS-VFCDM to renal blood flow data indicates some promise of a quantitative approach to understanding the dynamics of renal autoregulatory mechanisms as well as a possible approach to quantitatively discriminating between different strains of rats.
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Abbreviations
- BP:
-
blood pressure
- CBF:
-
cortical blood flow
- CDM:
-
complex demodulation
- CWT:
-
continuous wavelet transform
- FFCDM:
-
fixed-frequency complex demodulation
- FIR:
-
finite impulse response
- HHT:
-
Hilbert–Huang transform
- LPF:
-
low-pass filter
- RAP:
-
renal arterial pressure
- SDR:
-
Spragure–Dawley rat
- SHR:
-
spontaneously hypertensive rat
- SPWV:
-
smoothed pseudo Wigner–Ville
- STFT:
-
short time Fourier transform
- TF:
-
time-frequency
- TFS:
-
time–frequency spectra
- TGF:
-
tubuloglomerular feedback
- TPU:
-
tissue perfusion units
- TV:
-
time-varying
- TVOPS:
-
time-varying optimal parameter search
- VFCDM:
-
variable frequency complex demodulation
REFERENCES
Akay, M. Time Frequency and Wavelets in Biomedical Signal Processing. Piscataway, NJ: IEEE, 1998.
Bidani, A. K., M. M. Schwartz, and E. J. Lewis. Renal autoregulation and vulnerability to hypertensive injury in remnant kidney. Am. J. Physiol. 252:F1003–F1010, 1987.
Chon, K. H. Accurate identification of periodic oscillations buried in white or colored noise using fast orthogonal search. IEEE Trans. Biomed. Eng. 48:622–629, 2001.
Cohen, L. Time-Frequency Analysis. Upper Saddle River, NJ: Prentice-Hall, 1995.
Gasquet, H., and A. J. Wootton. Variable-frequency complex demodulation technique for extracting amplitude and phase information. Rev. Sci. Instrum. 68:1111–1114, 1997.
Harrop, J. D., S. N. Taraskin, and S. R. Elliott. Instantaneous frequency and amplitude identification using wavelets: Application to glass structure. Phys. Rev. E 66(2):026703, 2002.
Holstein-Rathlou, N. H., A. J. Wagner, and D. J. Marsh. Tubuloglomerular feedback dynamics and renal blood flow autoregulation in rats. Am. J. Physiol. 260:F53–F68, 1991.
Huang, W., Z. Shen, N. E. Huang, and Y. C. Fung. Engineering analysis of biological variables: An example of blood pressure over 1 day. Proc. Natl. Acad. Sci. U.S.A. 95(9):4816–4821, 1998.
Huang, N. E., Z. Shen, S. R. Long, M. L. Wu, H. H. Shih, Q. Zheng, N. C. Yen, C. C. Tung, and H. H. Liu. The empirical mode decomposition and Hilbert spectrum for nonlinear and non-stationary time series analysis. Proc. R. Soc. Lond. A 454:903–995, 1998.
Ktonas, P. Y., and N. Papp. Instantaneous envelope and phase extraction from real signals—theory, implementation, and an application to EEG analysis. Signal Process. 2(4):373–385, 1980.
Marple, S. L. Jr. Digital Spectral Analysis with Applications. Englewood Cliffs, NJ: Prentice-Hall, 1987.
Monti, A., C. Medigue, and L. Mangin. Instantaneous parameter estimation in cardiovascular time series by harmonic and time-frequency analysis. IEEE Trans. Biomed. Eng. 49:1547–1556, 2002.
Niedzwiecki, M. Identification of Time-Varying Processes. New York: Wiley, 2000.
Pola, S., A. Macerata, M. Emdin, and C. Marchesi. Estimation of the power spectral density in nonstationary cardiovascular time series: Assessing the role of the time–frequency representations (TFR). IEEE Trans. Biomed. Eng. 43(1):46–59, 1996.
Wang, H., K. Siu, K. H. Ju, L. Moore, and K. H. Chon. Identification of transient renal autoregulatory mechanisms using time–frequency spectral techniques. IEEE Trans. Biomed. Eng. 52(6):1033–1039, 2005.
Yip, K. P., N. H. Holstein-Rathlou, and D. J. Marsh. Dynamics of TGF-initiated nephron–nephron interactions in normotensive rats and SHR. Am. J. Physiol. 262:F980–F988, 1992.
Zar, J. H. Biostatistical Analysis. Upper Saddle River, NJ: Prentice-Hall, 1999.
Zou, R., H. Wang, and K. H. Chon. A robust time-varying identification algorithm using basis functions. Ann. Biomed. Eng. 31:840–853, 2003.
ACKNOWLEDGMENTS
This work was supported in part by a grant from NIH: HL69629. The authors would like to thank Prof. Leon Moore and A. Birzgalis for their expert technical assistance in renal data measurements.
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Appendices
APPENDIX A: HILBERT TRANSFORM
For an arbitrary time series, X(t) (we assume that X(t) contains center frequency oscillations, i.e., f 0), its Hilbert transform, Y(t), is as follows:
APPENDIX B: TIME-VARYING OPTIMAL PARAMETER SEARCH (TVOPS)
The TVOPS method is based on estimating only a few time-varying coefficients that best characterize the dynamics of the system to within a specified degree of accuracy. Thus, the resulting time-varying spectra are not data length dependent, meaning that they are high-resolution time-frequency spectra which are immune from cross-term spectral artifacts when there are multiple components in the signal. To obtain TV spectra, the data are formulated into a time-varying autoregressive (TVAR) model of the form:
where \(a(i,n)\) are the TVAR coefficients to be determined, and are functions of time. Index P is the maximum order of the AR model. The term e(n) is the residual error. The TVAR coefficients are expanded onto a set of basis functions and then the optimal parameter search algorithm is used to select only the significant TV terms among the chosen P terms. The next step is then to use either the least squares or total least squares methods to estimate TV coefficients. For full details of the TVOPS algorithm, the reader is referred to Reference.18
After obtaining the TV coefficients a(i, n), we can calculate the TV spectrum, S(n, ω) as follows:
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Wang, H., Siu, K., Ju, K. et al. A High Resolution Approach to Estimating Time-Frequency Spectra and Their Amplitudes. Ann Biomed Eng 34, 326–338 (2006). https://doi.org/10.1007/s10439-005-9035-y
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DOI: https://doi.org/10.1007/s10439-005-9035-y