Skip to main content

Advertisement

Log in

Reaching the 90–90–90 UNAIDS treatment target for people who inject drugs receiving integrated clinical care at a drug-use outpatient treatment facility

  • Original Article
  • Published:
Journal of Public Health Aims and scope Submit manuscript

Abstract

Background

People who inject drugs (PWID) experience more gaps at each stage of the HIV care continuum than others living with HIV. The study aimed to describe the effectiveness of an integrated care model to reach the UNAIDS 90–90–90 target.

Methods

This cross-sectional study included PWID who met the criteria for DSM-5 substance use disorder. They received a multidisciplinary comprehensive program, including medical HIV care, substance use treatment, and psychosocial support, at a drug-use treatment outpatient facility during 2019. The percentage of patients reaching the 90–90–90 UNAIDS target was the main study variable.

Results

Two hundred and twenty-one PWID were monitored at the facility during a median follow-up of 98 months (IQR: 61–143). Current HIV status was established in all PWID, of whom 84/221 (38.0%) tested HIV-positive. All the 84 patients (100%) received antiretroviral therapy, and 76(90.5%) had RNA HIV-1 < 20 copies/ml during a median of 74 months (IQR: 36–115). The UNAIDS goals were: 84/84 (100%) for the HIV testing, 84/84 (100%) for patients on antiretroviral therapy, and 76/84 (90.5%) for viral suppression.

Conclusions

Integrated clinical care provided at a drug-use treatment facility is a useful strategy to sustain a long-term HIV care continuum among PWID.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bradley H, Hall HI, Wolitski RJ, Van Handel MM, Stone AE, LaFlam M, Skarbinski J, Higa DH, Prejean J, Frazier EL, Patel R, Huang P, An Q, Song R, Tang T, Valleroy LA (2014) Vital signs: HIV diagnosis, care, and treatment among persons living with HIV United States, 2011. MMWR Morb Mortal Wkly Rep 63(47):1113–1117

    PubMed  PubMed Central  Google Scholar 

  • Connery HS (2015) Medication-assisted treatment of opioid use disorder: review of the evidence and future directions. Harv Rev Psychiatry 23(2):63–75

    Article  Google Scholar 

  • DeBeck K, Cheng T, Montaner JS, Beyrer C, Elliott R, Sherman S, Wood E, Baral S (2017) HIV and the criminalisation of drug use among people who inject drugs: a systematic review. Lancet HIV 4(8):e357-e374. https://doi.org/10.1016/S2352-3018(17)30073-5

  • De La Fuente L, Bravo MJ, Barrio G, Parras F, Suárez M, Rodés A, Noguer I (2003) Lessons from the history of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic among Spanish drug injectors. Clin Infect Dis 37(S5):410–415

    Article  Google Scholar 

  • European Monitoring Center for Drugs and Drug Addiction (2017) Responding to the needs of ageing drug users. http://www.emcdda.europa.eu/system/files/attachments/6225/EuropeanResponsesGuide2017_BackgroundPaper-Ageing-drug-users.pdf

  • Folch C, Lorente N, Majó X, Parés-Badell O, Roca X, Brugal T, Roux P, Carrieri P, Colom J, Casabona J, REDAN study group (2018) Drug consumption rooms in Catalonia: a comprehensive evaluation of social, health and harm reduction benefits. Int J Drug Policy 62:24–29

    Article  Google Scholar 

  • Gormley R, Lin SY, Carter A, Nicholson V, Webster K, Martin RE, Milloy MJ, Pick N, Howard T, Wang L, de Pokomandy A, Loutfy M, Kaida A, Research Team CHIWOS (2019) Social determinants of health and retention in HIV care among recently incarcerated women living with HIV in Canada. AIDS Behav 24(4):1212–1225. https://doi.org/10.1007/s10461-019-02666-7

  • Granich R, Gupta S, Hall I, Aberle-Grasse J, Hader S, Mermin J (2017) Status and methodology of publicly available national HIV care continua and 90–90–90 targets: a systematic review. PLoS Med 14(4):e1002253. https://doi.org/10.1371/journal.pmed.1002253

    Article  PubMed  PubMed Central  Google Scholar 

  • Hakim AJ, MacDonald V, Hladik W, Zhao J, Burnett J, Sabin K, Prybylski D, Garcia Calleja JM (2018) Gaps and opportunities: measuring the key population cascade through surveys and services to guide the HIV response. J Int AIDS Soc 21(Suppl 5):e25119. https://doi.org/10.1002/jia2.25119

  • Haldane V, Cervero-Liceras F, Chuah FL, Ong SE, Murphy G, Sigfrid L, Watt N, Balabanova D, Hogarth S, Maimaris W, Buse K, Piot P, McKee M, Perel P, Legido-Quigley H (2017) Integrating HIV and substance use services: a systematic review. J Int AIDS Soc 20(1):21585. https://doi.org/10.7448/IAS.20.1.21585

    Article  PubMed  PubMed Central  Google Scholar 

  • Kay ES, Batey DS, Mugavero MJ (2016) The HIV treatment cascade and care continuum: updates, goals, and recommendations for the future. AIDS Res Ther 13:35. https://doi.org/10.1186/s12981-016-0120-0

    Article  PubMed  PubMed Central  Google Scholar 

  • Lesko CR, Tong W, Moore RD, Lau B (2017) Retention, antiretroviral therapy use and viral suppression by history of injection drug use among HIV-infected patients in an urban HIV clinical cohort. AIDS Behav 21(4):1016–1024

    Article  Google Scholar 

  • Lourenço L, Colley G, Nosyk B, Shopin D, Montaner JS, Lima VD, STOP HIV/AIDS Study Group (2014) High levels of heterogeneity in the HIV cascade of care across different population subgroups in British Columbia, Canada. PLoS One 9(12):e115277. https://doi.org/10.1371/journal.pone.0115277

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Low AJ, Mburu G, Welton NJ, May MT, Davies CF, French C, Turner KM, Looker KJ, Christensen H, McLean S, Rhodes T, Platt L, Hickman M, Guise A, Vickerman P (2016) Impact of opioid substitution therapy on antiretroviral therapy outcomes: a systematic review and meta-analysis. Clin Infect Dis 63(8):1094–1104

    Article  CAS  Google Scholar 

  • MacCarthy S, Hoffmann M, Ferguson L, Nunn A, Irvin R, Bangsberg D, Gruskin S, Dourado I (2015) The HIV care cascade: models, measures and moving forward. J Int AIDS Soc 8(1):19395. https://doi.org/10.7448/IAS.18.1.19395

    Article  Google Scholar 

  • Marsh K, Eaton JW, Mahy M, Sabin K, Autenrieth CS, Wanyeki I, Daher J, Ghys PD (2019) Global, regional and country-level 90–90–90 estimates for 2018: assessing progress towards the 2020 target. AIDS 33(S3):213–226

    Article  Google Scholar 

  • Mazhnaya A, Marcus R, Bojko MJ, Zelenev A, Makarenko I, Pykalo I, Filippovych S, Dvoriak S, Altice FL (2018) Opioid agonist treatment and improved outcomes at each stage of the HIV treatment cascade in people who inject drugs in Ukraine. J Acquir Immune Defic Syndr 79(3):288–295

    Article  Google Scholar 

  • McHugh RK, Votaw VR, Sugarman DE, Greenfield SF (2018) Sex and gender differences in substance use disorders. Clin Psychol Rev 66:12–23

    Article  Google Scholar 

  • Metsch L, Philbin MM, Parish C, Shiu K, Frimpong JA, Giangle M (2015) HIV testing, care, and treatment among women who use drugs from a global perspective: Progress and challenges. J Acquir Immune Defic Syndr 69(S2):162–168

    Article  Google Scholar 

  • Meyer JP, Althoff AL, Altice FL (2013) Optimizing care for HIV-infected people whouse drugs: evidence-based approaches to overcoming healthcare disparities. Clin Infect Dis 57(9):1309–1317

    Article  Google Scholar 

  • Montaner JSG (2011) Treatment as prevention: a double hat-trick. Lancet 378:208–209

    Article  Google Scholar 

  • Nosyk B, JSG M, Colley G, Lima VD, Chan K, Heath K, Yip B, Samji H, Gilbert M, Barrios R, Gustafson R, Hogg RS, STOP HIV/AIDS Study Group (2014) The cascade of HIV care in British Columbia, Canada, 1996–2011: a population-base retrospective cohort study. Lancet Infect Dis 14(1):40–49

    Article  Google Scholar 

  • Nosyk B, Min JE, Evans E, Li L, Liu L, Lima VD, Wood E, Montaner JS (2015) The efects of opioid substitution treatment and highly active antiretroviral therapy on the causespecifc risk of mortality among HIV-positive people who inject drugs. Clin Infect Dis 61(7):1157–1165

    Article  CAS  Google Scholar 

  • Oldfield BJ, Muñoz N, McGovern MP, Funaro M, Villanueva M, Tetrault JM, Edelman EJ (2019) Integration of care for HIV and opioid use disorder. AIDS 33(5):873–884

    Article  Google Scholar 

  • Prabhu S, McFall AM, Mehta SH, Srikrishnan AK, Kumar MS, Anand S, Shanmugam S, Celentano DD, Lucas GM, Solomon SS (2020) Psychosocial barriers to viral suppression in a community-based sample of HIV-positive men who have sex with men and people who inject drugs in India. Clin Infect Dis 70(2):304–313

    Article  Google Scholar 

  • Rajaratnam R, Sivesind D, Todman M, Roane D, Seewald R (2009) The aging methadone maintenance patient: treatment adjustment, long-term success, and quality of life. J Opioid Manag 5(1):27–37

    Article  Google Scholar 

  • Risher K, Mayer KH, Beyrer C (2015) HIV treatment cascade in MSM, people who inject drugs, and sex workers. Curr Opin HIV AIDS 10(6):420–429

    Article  CAS  Google Scholar 

  • Roux P, Carrieri MP, Villes V, Dellamonica P, Poizot-Martin I, Ravaux I, Spire B, MANIF2000 cohort study group (2008) The impact of methadone or buprenorphine treatment and ongoing injection on highly active antiretroviral therapy (HAART) adherence: evidence from the MANIF2000 cohort study. Addiction 103(11):1828–1836

    Article  Google Scholar 

  • Sarvet AL, Hasin D (2016) The natural history of substance use disorders. Curr Opin Psychiatry 29(4):250–257

    Article  Google Scholar 

  • Spire B, Lucas GM, Carrieri MP (2007) Adherence to HIV treatment among IDUs and the role of opioid substitution treatment (OST). Int J Drug Policy 18(4):262–270

    Article  Google Scholar 

  • Sterling S, Chi F, Hinman A (2011) Integrating care for people with co-occurring alcohol and other drug, medical, and mental health conditions. Alcohol Res Health 33(4):338–349

    PubMed  PubMed Central  Google Scholar 

  • Torrens M, Fonseca F, Castillo C, Domingo-Salvany A (2013) Methadone maintenance treatment in Spain: the success of a harm reduction approach. Bull World Health Organ 91(2):136–141

    Article  Google Scholar 

  • Timko C, Schultz NR, Cucciare MA, Vittorio L, Garrison-Diehn C (2016) Retention in medication-assisted treatment for opiate dependence: a systematic review. J Addict Dis 35(1):22–35

    Article  Google Scholar 

  • UNAIDS (2016) HIV care and support taking into account. UNAIDS, Geneva. https://www.unaids.org/sites/default/files/media_asset/JC2741_HIV-care-and-support_en.pdf

  • UNAIDS (2014) 90–90-90: An ambitious treatment target to help end the AIDS epidemic. UNAIDS, Geneva. http://www.unaids.org/en/resources/documents/2014/90-90-90

  • UNAIDS (2019) Indicators for monitoring the 2016 Political Declaration on Ending AIDS. UNAIDS, Geneva. https://www.unaids.org/sites/default/files/media_asset/global-aids-monitoring_en.pdf

  • Vallecillo G, Mojal S, Roquer A, Samos P, Luque S, Martinez D, Martires PK, Torrens M (2016) Low non-structured antiretroviral therapy interruptions in HIV-infected persons who inject drugs receiving multidisciplinary comprehensive HIV care at an outpatient drug abuse treatment center. AIDS Behav 20(5):1068–1075

    Article  Google Scholar 

  • Witkiewitz K, Marlatt GA (2004) Relapse prevention for alcohol and drug problems: that was Zen, this is Tao. Am Psychol 59(4):224–235

    Article  Google Scholar 

  • Wood E, Kerr T, Tyndall MW, Montaner JS (2008) A review of barriers and facilitators of HIV treatment among injection drug users. AIDS 22(11):1247–1256

    Article  Google Scholar 

Download references

Acknowledgements

Thanks to Stephanie Lonsdale for manuscript editing and editorial assistance.

Funding

Instituto de Salud Carlos III–FEDER-Red de Trastornos Adictivos UE-FEDER 2016 (RD16/0017/0010); AGAUR-Suport Grups de Recerca (2017 SGR530) and Acció instrumental d’Intensificació de Professionals de la Salut – Facultatius especialistes (PERIS: SLT006/17/00014).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to G. Vallecillo.

Ethics declarations

Ethical approval was obtained from the local ethics committee of the hospital (CEIC 2019/8779). All information collected from this study was kept strictly confidential. All study procedures were in accordance with the ethics committee standards.

Conflict of interest

None of the authors declare any conflict of interest or has any financial disclosure.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vallecillo, G., Fonseca, F., Marín, G. et al. Reaching the 90–90–90 UNAIDS treatment target for people who inject drugs receiving integrated clinical care at a drug-use outpatient treatment facility. J Public Health (Berl.) 30, 481–486 (2022). https://doi.org/10.1007/s10389-020-01298-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10389-020-01298-9

Keywords

Navigation