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A factor for predicting simultaneous internal limiting membrane peeling during epiretinal membrane removal: swept-source optical coherence tomography-based evaluation of epiretinal membrane adhesion to the retina

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate preoperative factors associated with simultaneous internal limiting membrane (ILM) peeling during epiretinal membrane (ERM) removal.

Study design

Observational cross-sectional study.

Methods

We retrospectively reviewed 60 eyes with idiopathic ERM that underwent vitrectomy. The gap between the ERM and ILM was visualized using en face optical coherence tomography. The depth and width of the ERM–ILM gap at the initiation site of ERM removal were measured, and the relationship between preoperative factors including these parameters and simultaneous ILM peeling during ERM removal was investigated.

Results

The ILM was simultaneously peeled during ERM removal in 30 eyes, but not in the other 30 eyes. Age was significantly higher (P = 0.017) and the width of the ERM–ILM gap was significantly smaller (P < 0.001) in the simultaneous ILM peeling (+) group than in the simultaneous ILM peeling (–) group. Multivariate logistic regression analysis confirmed the width of the ERM–ILM gap as a significant negative predictor for simultaneous ILM peeling (odds ratio, 0.992; 95% confidence interval, 0.986–0.997; P = 0.003). Receiver operating characteristic curve analysis of the width of the ERM–ILM gap revealed that the optimal cutoff for predicting simultaneous ILM peeling was 187.1 µm.

Conclusion

The small width of the ERM–ILM gap at the initiation site of ERM removal was significantly associated with simultaneous ILM peeling, indicating that the adhesion strength between the ERM and ILM at the initial ERM grasping site determines whether simultaneous ILM peeling will occur during ERM removal.

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References

  1. Matoba R, Morizane Y. Surgical treatment of epiretinal membrane. Acta Med Okayama. 2021;75:403–13.

    PubMed  Google Scholar 

  2. Azuma K, Ueta T, Eguchi S, Aihara M. Effects of internal limiting membrane peeling combined with removal of idiopathic epiretinal membrane: a systematic review of literature and meta-analysis. Retina. 2017;37:1813–9.

    Article  PubMed  Google Scholar 

  3. Chang WC, Lin C, Lee CH, Sung TL, Tung TH, Liu JH. Vitrectomy with or without internal limiting membrane peeling for idiopathic epiretinal membrane: a meta-analysis. PLoS ONE. 2017;12: e0179105.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Huang Q, Li J. With or without internal limiting membrane peeling during idiopathic epiretinal membrane surgery: a meta-analysis. PLoS ONE. 2021;16: e0245459.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Spaide RF. Dissociated optic nerve fiber layer appearance’ after internal limiting membrane removal is inner retinal dimpling. Retina. 2012;32:1719–26.

    Article  PubMed  Google Scholar 

  6. Uemura A, Kanda S, Sakamoto Y, Kita H. Visual field defects after uneventful vitrectomy for epiretinal membrane with indocyanine green-assisted internal limiting membrane peeling. Am J Ophthalmol. 2003;136:252–7.

    Article  PubMed  Google Scholar 

  7. Terasaki H, Miyake Y, Nomura R, Piao CH, Hori K, Niwa T, et al. Focal macular ERGs in eyes after removal of macular ILM during macular hole surgery. Invest Ophthalmol Vis Sci. 2001;42:229–34.

    CAS  PubMed  Google Scholar 

  8. Tsuchiya S, Higashide T, Sugiyama K. Visual field changes after vitrectomy with internal limiting membrane peeling for epiretinal membrane or macular hole in glaucomatous eyes. PLoS ONE. 2017;12: e0177526.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Hirano M, Morizane Y, Kimura S, Hosokawa M, Shiode Y, Doi S, et al. Assessment of lamellar macular hole and macular pseudohole with a combination of en face and radial B-scan optical coherence tomography imaging. Am J Ophthalmol. 2018;188:29–40.

    Article  PubMed  Google Scholar 

  10. Matoba R, Kanzaki Y, Doi S, Kanzaki S, Kimura S, Hosokawa MM, et al. Assessment of epiretinal membrane formation using en face optical coherence tomography after rhegmatogenous retinal detachment repair. Graefes Arch Clin Exp Ophthalmol. 2021;259:2503–12.

    Article  CAS  PubMed  Google Scholar 

  11. Kanzaki Y, Doi S, Matoba R, Kanzaki S, Kimura S, Hosokawa MM, et al. Objective and quantitative estimation of the optimal timing for epiretinal membrane surgery on the basis of metamorphopsia. Retina. 2021;42:704–11.

    Article  Google Scholar 

  12. Kim JS, Chhablani J, Chan CK, Cheng L, Kozak I, Hartmann K, et al. Retinal adherence and fibrillary surface changes correlate with surgical difficulty of epiretinal membrane removal. Am J Ophthalmol. 2012;153(692–7):697.e1-2.

    Google Scholar 

  13. Pavlidis M, Georgalas I, Körber N. Determination of a new parameter, elevated epiretinal membrane, by en face OCT as a prognostic factor for pars plana vitrectomy and safer epiretinal membrane peeling. J Ophthalmol. 2015;2015: 838646.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Charles S. Techniques and tools for dissection of epiretinal membranes. Graefes Arch Clin Exp Ophthalmol. 2003;241:347–52.

    Article  PubMed  Google Scholar 

  15. Beyhan B, Güler C, Tağa H. An algorithm for maximum inscribed circle based on voronoi diagrams and geometrical properties. J Geogr Syst. 2020;22:391–418.

    Article  Google Scholar 

  16. Matoba R, Morizane Y, Kimura S, Toshima S, Shiraga F. Retinal nerve fiber layer defect and paracentral scotoma after internal limiting membrane peeling with a nitinol loop. Acta Med Okayama. 2017;71:539–42.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho Kita-ku, Okayama City, Okayama, 700-8558, Japan

    Ryo Matoba, Yuki Kanzaki, Shuhei Kimura, Mio M. Hosokawa, Yusuke Shiode, Tetsuro Morita & Yuki Morizane

Authors
  1. Ryo Matoba
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  2. Yuki Kanzaki
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  3. Shuhei Kimura
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  4. Mio M. Hosokawa
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  5. Yusuke Shiode
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  6. Tetsuro Morita
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  7. Yuki Morizane
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Corresponding author

Correspondence to Ryo Matoba.

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Conflicts of interest

R. Matoba, None; Y. Kanzaki, None; S.Kimura, None; M. M. Hosokawa, None; Y. Shiode, None; T. Morita, None; Y. Morizane, None.

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Corresponding Author: Ryo Matoba

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Matoba, R., Kanzaki, Y., Kimura, S. et al. A factor for predicting simultaneous internal limiting membrane peeling during epiretinal membrane removal: swept-source optical coherence tomography-based evaluation of epiretinal membrane adhesion to the retina. Jpn J Ophthalmol 67, 410–416 (2023). https://doi.org/10.1007/s10384-023-00993-w

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  • DOI: https://doi.org/10.1007/s10384-023-00993-w

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