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Usefulness of handheld electroretinogram system for diagnosing blue-cone monochromatism in children

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To report the diagnosis of three childhood patients with blue-cone monochromatism (BCM) using S-cone electroretinograms (ERG) recorded with RETeval® Complete.

Study design

Prospective clinical study.

Methods

We examined three boys initially suspected of having rod monochromatism. S-cone ERG was performed with red background and blue flashed light stimulation using two different intensities: 0.25 cd × s/m2 and 1 cd × s/m2.

Results

Case 1 was a 12-year-old boy with a visual acuity of 0.1 OU. Case 2 was an 8-year-old boy with a visual acuity of 0.3 OD and 0.2 OS. Both cases showed a myopic fundus and nystagmus without any other ocular abnormalities. Case 3 was a 6-year-old boy with a visual acuity of 0.3 OD and 0.4 OS. He also showed myopic fundus changes, but nystagmus was not observed. Rod and maximal responses recorded with RETeval® were likely to be within normal range; however, cone responses were absent in all cases. S-cone ERGs showed positive responses at 40 ms with 0.25 cd × s/m2 intensity in Case 2, and at approximately 30–40 ms with 1.0 cd × s/m2 intensity in all three cases. These ERG findings led to a diagnosis of BCM.

Conclusions

S-cone ERG of RETeval® was helpful in diagnosing with minimal invasion BCM in childhood patients.

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Acknowledgements

The authors would like to thank Editage (https://www.editage.jp//) for English language editing.

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Authors and Affiliations

  1. Department of Ophthalmology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu-shi, Higashi-ku, Shizuoka, 431-3192, Japan

    Takashi Haseoka, Risako Inagaki, Kentaro Kurata, Shinji Arai, Yuri Takagi, Hiroko Suzuki, Akiko Hikoya, Yoshihiro Hotta & Miho Sato

  2. Shizuoka Children’s Hospital, Shizuoka, Japan

    Kasumi Nishimura

  3. Ueno Ganka Clinic Ophthalmology, Shizouka, Japan

    Kasumi Nishimura

Authors
  1. Takashi Haseoka
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  2. Risako Inagaki
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  3. Kentaro Kurata
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  4. Shinji Arai
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  5. Yuri Takagi
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  6. Hiroko Suzuki
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  7. Akiko Hikoya
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  8. Kasumi Nishimura
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  9. Yoshihiro Hotta
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  10. Miho Sato
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Corresponding author

Correspondence to Miho Sato.

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Conflicts of interest

T. Haseoka, None; R. Inagaki, None; K. Kurata, None; S. Arai, None; Y. Takagi, None; H. Suzuki, None; A. Hikoya, None; K. Nishimura, None; Y. Hotta, None; M. Sato, None.

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Corresponding Author: Miho Sato

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Haseoka, T., Inagaki, R., Kurata, K. et al. Usefulness of handheld electroretinogram system for diagnosing blue-cone monochromatism in children. Jpn J Ophthalmol 65, 23–29 (2021). https://doi.org/10.1007/s10384-020-00782-9

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  • DOI: https://doi.org/10.1007/s10384-020-00782-9

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