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Descemet stripping and automated endothelial keratoplasty (DSAEK) versus non-Descemet stripping and automated endothelial keratoplasty (nDSAEK) for bullous keratopathy

  • Clinical Investigation
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Abstract

Purpose

To investigate the long-term results of Descemet stripping and automated endothelial keratoplasty (DSAEK) versus non-Descemet stripping and automated endothelial keratoplasty (nDSAEK) for non-Fuchs bullous keratopathy.

Study design

Retrospective comparative study.

Methods

Twenty-nine eyes of 28 patients who underwent DSAEK and 60 eyes of 56 patients who underwent nDSAEK for bullous keratopathy were retrospectively analyzed in a clinical case-control study. All the operations were done using precut donor buttons prepared by overseas eye banks. The recipient Descemet membrane was stripped in DSAEK, whilst it was left intact in nDSAEK. Donor buttons were inserted through a 4.2-mm corneal incision using the pull-through technique. Air was injected into the anterior chamber at the end of the operation. We investigated the visual acuity, refraction, endothelial cell density, and complications.

Results

The average best spectacle-corrected visual acuity (BSCVA) was significantly improved at all time points measured after surgery in both the DSAEK and the nDSAEK groups, and no significant differences were found between the 2 groups after surgery. No significant differences in spherical equivalent were found between the groups before and after surgery. The endothelial cell density gradually decreased after the operation in both groups; however, no significant difference between the 2 groups was found at any of the time points measured.

Conclusions

DSAEK and nDSAEK provided excellent refractive and reasonable visual outcomes in our long-term observation.

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Authors and Affiliations

  1. Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Risa Yamazaki, Yoshiyuki Ichihashi, Kazuo Tsubota & Shigeto Shimmura

  2. Miyata Eye Hospital, Miyazaki, Japan

    Ryohei Nejima & Kazunori Miyata

Authors
  1. Risa Yamazaki
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  2. Ryohei Nejima
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  3. Yoshiyuki Ichihashi
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  4. Kazunori Miyata
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  5. Kazuo Tsubota
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  6. Shigeto Shimmura
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Corresponding author

Correspondence to Shigeto Shimmura.

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Conflicts of interest

R. Yamazaki, None; R. Nejima, None; Y. Ichihashi, None; K. Miyata, None; K. Tsubota, None; S. Shimmura, None.

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Corresponding Author: Shigeto Shimmura

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Yamazaki, R., Nejima, R., Ichihashi, Y. et al. Descemet stripping and automated endothelial keratoplasty (DSAEK) versus non-Descemet stripping and automated endothelial keratoplasty (nDSAEK) for bullous keratopathy. Jpn J Ophthalmol 64, 585–590 (2020). https://doi.org/10.1007/s10384-020-00767-8

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  • DOI: https://doi.org/10.1007/s10384-020-00767-8

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