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Changes in choroidal thickness and optical axial length accompanying intraocular pressure increase

  • Clinical Investigation
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Abstract

Purpose

To measure changes in choroidal thickness (CT), retinal thickness (RT), and axial length (AL) accompanying intraocular pressure (IOP) increase and to investigate the changes in axial eye dimensions induced by IOP increase.

Methods

Thirty-four eyes of 34 patients undergoing a diagnostic provocative test for primary angle closure (PAC). Patients with other macular diseases were excluded. Patients underwent the darkroom prone provocative test (DR-PPT) for 1 h. We measured CT and RT at the fovea by optical coherence tomography with the enhanced depth imaging method and AL with noncontact, partial coherence laser interferometry before and after the DR-PPT.

Results

There was a statistically significant increase in the mean (SD) IOP of 7.3 (9.2) mmHg and the mean (SD) AL of 0.06 (0.12) mm after the DR-PPT (P < 0.001 and P = 0.014, respectively). There was a statistically significant decrease in the mean (SD) subfoveal CT of 30.0 (36.8) μm (P < 0.001), while there was no significant change in the mean foveal RT. The change in subfoveal CT was negatively correlated with the changes in IOP (r = −0.71, P < 0.001) and AL (r = −0.54, P = 0.004).

Conclusions

In eyes suspected of having PAC, acutely increased IOP accompanies choroid thinning and corresponding elongation of the optical axis.

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Acknowledgments

The authors had no financial support or financial conflict of interest. Contributions of authors: design (MH); collection (MH, FH), analysis, and interpretation (MH, FH, AO) of the data; and preparation (FH, AO, YH), review (FH, AO, YH, YK), and approval (MH, FH, AO, YH, YK) of the manuscript. All procedures conformed to the tenets of the Declaration of Helsinki, and the study design was prospectively approved by the institutional review board of Kobe City Medical Center General Hospital. The review board waived the need for written informed consent for reviewing the retrospective data.

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Authors and Affiliations

  1. Department of Ophthalmology, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-minamimachi, Chuo-ku, Kobe, 650-0047, Japan

    Masayuki Hata, Fumitaka Hirose, Akio Oishi, Yasuhiko Hirami & Yasuo Kurimoto

  2. Laboratory for Retinal Regeneration, Center for Developmental Biology, Riken, Kobe, Japan

    Yasuhiko Hirami

Authors
  1. Masayuki Hata
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  2. Fumitaka Hirose
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  3. Akio Oishi
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  4. Yasuhiko Hirami
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  5. Yasuo Kurimoto
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Corresponding author

Correspondence to Masayuki Hata.

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Hata, M., Hirose, F., Oishi, A. et al. Changes in choroidal thickness and optical axial length accompanying intraocular pressure increase. Jpn J Ophthalmol 56, 564–568 (2012). https://doi.org/10.1007/s10384-012-0173-0

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  • DOI: https://doi.org/10.1007/s10384-012-0173-0

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