Skip to main content

Advertisement

SpringerLink
Log in

Changes in choroidal thickness following trabeculectomy and its correlation with the decline in intraocular pressure

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

Evaluate whether there are significant changes in choroidal thickness following trabeculectomy, and how they relate do the decline in intraocular pressure.

Methods

This was a prospective evaluation of 28 eyes who underwent Moorfields modified trabeculectomy. The choroidal thickness was measured via OCT with enhanced depth imaging, before surgery and 1 day, 1 week and 1 month after surgery. Measurements were taken at the fovea, 1000 µm temporal to the fovea and 1000 µm nasal to the fovea. The relationship between choroidal thickness and intraocular pressure was statistically evaluated.

Results

The mean intraocular pressure before surgery was 25.07 ± 4.64 mmHg; 8.57 ± 3.62 mmHg after 1 day; 10.36 ± 4.39 mmHg after 1 week and 13.71 ± 5.13 mmHg after 1 month. Mean choroidal thickness increased after trabeculectomy with maximal values at 1 week. The largest increase was found at the fovea, with an average before surgery of 253.54 ± 62.01 µm; 286.75 ± 64.20 µm at 1 day, 286.36 ± 63.14 µm at 1 week and 271.00 ± 60.31 µm at 1 month. Increase in choroidal thickness was significant 1 day and 1 week after surgery in the foveal (p = 0.012, p = 0.007) and temporal (p = 0.040, p = 0.000) locations and 1 week postoperatively on the nasal location (p = 0.016). None of them were significant at 1 month after surgery. Preoperative IOP and choroidal thickness were correlated at all macular locations (ρ = 0.449–0.525, p = 0.004–0.016) yet no correlation was found between increase in choroidal thickness and decline in intraocular pressure in the postoperative period.

Conclusion

Choroidal thickness appears to increase temporarily after trabeculectomy and these changes were not correlated with the decline in intraocular pressure. Further research is required to fully understand this phenomenon.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Pederson JE (1984) Hypotony. In: Duane TD (ed) Clinical ophthalmology, chapter 58, vol 3. Harper & Row, Philadelphia, pp 1–8

    Google Scholar 

  2. Stamper RL, McMenemy MG, Lieberman MF (1992) Hyptonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil. Am J Ophthalmol 114:544–553

    Article  CAS  PubMed  Google Scholar 

  3. Suner IJ, Greenfield DS, Miller MP, Nicolela MT, Palmberg PF (1997) Hypotony maculopathy after filtering surgery with mitomycin C. Incidence and treatment. Ophthalmology 104:207–214

    Article  CAS  PubMed  Google Scholar 

  4. Cashwell LF, Martin CA (1999) Axial length decrease accompanying successful glaucoma filtration surgery. Ophthalmology 106:2307–2311

    Article  CAS  PubMed  Google Scholar 

  5. Berisha F, Schmetterer K, Vass C, Dallinger S, Rainer G, Findl O et al (2005) Effect of trabeculectomy on ocular blood flow. Br J Ophthalmol 89:185–188

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Margolis R, Spaide RF (2009) A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 147:811–815

    Article  PubMed  Google Scholar 

  7. Spaide RF, Koizumi H, Pozzoni MC (2008) Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 146:496–500

    Article  Google Scholar 

  8. Kara N, Baz O, Altan C, Satana B, Kurt T, Demirok A (2013) Changes in choroidal thickness, axial length, and ocular perfusion pressure accompanying successful glaucoma filtration surgery. Eye 27(8):940–945

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Usui S, Ikuno Y, Uematsu S, Morimoto Y, Yasuno Y, Otori Y (2013) Changes in axial length and choroidal thickness after intraocular pressure reduction resulting from trabeculectomy. Clin Ophthalmol 7:1155–1161

    Article  PubMed  PubMed Central  Google Scholar 

  10. Saeedi O, Pillar A, Jefferys J, Arora K, Friedman D, Quigley H (2014) Change in choroidal thickness and axial length with change in intraocular pressure after trabeculectomy. Br J Ophthalmol 98(7):976–979

    Article  PubMed  Google Scholar 

  11. Chen S, Wang W, Gao X, Li Z, Huang W, Li X, Zhou M, Zhang X (2014) Changes in choroidal thickness after trabeculectomy in primary angle closure glaucoma. Investig Ophthalmol Vis Sci 55(4):2608–2613

    Article  Google Scholar 

  12. Esmaeelpour M, Povazay B, Hermann B, Hofer B, Kajic V, Kapoor K et al (2010) Three-dimensional 1060-nm OCT: choroidal thickness maps in normal subjects and improved posterior segment visualization in cataract patients. Investig Ophthalmol Vis Sci 51:5260–5266

    Article  Google Scholar 

  13. Fujiwara T, Imamura Y, Margolis R, Slakter JS, Spaide RF (2009) Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol 148:445–450

    Article  PubMed  Google Scholar 

  14. Ikuno Y, Tano Y (2009) Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography. Investig Ophthalmol Vis Sci 50:3876–3880

    Article  Google Scholar 

  15. Mwanza JC, Hochberg JT, Banitt MR, Feuer WJ, Budenz DL (2011) Lack of association between glaucoma and macular choroidal thickness measured with enhanced depth-imaging optical coherence tomography. Investig Ophthalmol Vis Sci 52:3430–3435

    Article  Google Scholar 

  16. Ikuno Y, Kawaguchi K, Nouchi T, Yasuno Y (2010) Choroidal thickness in healthy Japanese subjects. Investig Ophthalmol Vis Sci 51:2173–2176

    Article  Google Scholar 

  17. Nickla DL, Wallman J (2010) The multifunctional choroid. Prog Retin Eye Res 29:144–168

    Article  Google Scholar 

  18. Rahman W, Chen FK, Yeoh J, Patel P, Tufail A, Da Cruz L (2011) Repeatability of manual subfoveal choroidal thickness measurements in healthy subjects using the technique of enhanced depth imaging optical coherence tomography. Investig Ophthalmol Vis Sci 52(5):2267–2271

    Article  Google Scholar 

  19. Karaca EE, Özdek Ş, Yalçin NG, Ekici F (2014) Reproducibility of choroidal thickness measurements in healthy Turkish subjects. Eur J Ophthalmol 24(2):202–208

    Article  PubMed  Google Scholar 

  20. Wong IY, Wong RL, Zhao P, Lai WW (2013) Choroidal thickness in relation to hypercholesterolemia on enhanced depth imaging optical coherence tomography. Retina 33(2):423–428

    Article  PubMed  Google Scholar 

  21. Akay F, Gundogan FC, Yolcu U, Toyran S, Uzun S (2016) Choroidal thickness in systemic arterial hypertension. Eur J Ophthalmol 26(2):152–157

    Article  PubMed  Google Scholar 

Download references

Funding

This study has not received any funding.

Author information

Authors and Affiliations

  1. Hospital Professor Doutor Fernando da Fonseca EPE (Amadora-Sintra), Lisbon, Portugal

    Diana Silva, Ana Sofia Lopes, Susana Henriques, Maria Lisboa, Sara Pinto, Fernando Trancoso Vaz & Isabel Prieto

Authors
  1. Diana Silva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ana Sofia Lopes
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Susana Henriques
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Maria Lisboa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sara Pinto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fernando Trancoso Vaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Isabel Prieto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Diana Silva.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Silva, D., Lopes, A.S., Henriques, S. et al. Changes in choroidal thickness following trabeculectomy and its correlation with the decline in intraocular pressure. Int Ophthalmol 39, 1097–1104 (2019). https://doi.org/10.1007/s10792-018-0918-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-018-0918-y

Keywords

Search

Navigation