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Influence of a moderate physical activity intervention on red cell deformability in patients suffering from chronic obstructive pulmonary disease (COPD)

Einfluss von moderatem Kraft- und Ausdauertraining auf die Erythrozytenflexibilität bei Patienten mit chronisch obstruktiver Lungenerkrankung (COPD)

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Summary

The present study investigates whether a moderate physical activity intervention may alter red cell deformability (RCD) of patients suffering from chronic obstructive pulmonary disease (COPD). Subjects (n = 10; age: 62 ± 4; body-mass index (BMI): 25.8 ± 7.5) performed a training regimen for 10 weeks. In the beginning of the study and after the training period, COPD patients underwent a WHO cycle ergometry test. Venous blood samples were taken before (T0), immediately after (T1) and 30 min after (T2) the intervention. RCD was measured with the laser-assisted optical rotational cell analyzer (LORCA). Significant improvements of the RCD were detected. The semi-maximal shear stress increased significantly. Acute exhaustion had no effect on RCD. Thus, the training period of 10 weeks influenced RCD.

Zusammenfassung

Die vorliegende Studie untersucht, ob eine moderate Intervention zur körperlichen Aktivität die Erythrozytenflexibilität (RCD) bei Patienten mit chronisch obstruktiver Lungenerkrankung (COPD) beeinflusst. Die Probanden (n = 10; Alter: 62 ± 4; BMI: 25,8 ± 7,5) unterzogen sich einer zehnwöchige Trainingsperiode. Zu Beginn und am Ende der Trainingsperiode absolvierten die COPD- Patienten einen WHO-Fahrrad-ergometrie-Test. Bevor (T0), unmittelbar nach (T1) und 30 min nach der Intervention (T2) wurde venöses Blut entnommen. Die RCD wurde mit dem Laser Assisted Optical Rotational Cell Analyzer (LORCA) gemessen. Signifikante Steigerungen der RCD wurden festgestellt. Die semimaximale Scherkraft steigerte sich signifikant. Akute Erschöpfung hatte keine Auswirkung auf die RCD. Die zehnwöchige Trainingsperiode beeinflusste somit die Erythrozytenflexibilität.

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Authors and Affiliations

  1. Department of Molecular and Cellular Sport Medicine, Institute for Cardiovascular Research and Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany

    Basit Ahmad Dip Sport Sci,  Wilhelm Bloch, Nina Skrobala &  Klara Brixius

  2. Institute of Movement and Neurosciences, German Sport University Cologne, Cologne, Germany

    Nina Ferrari PhD Sport Sci

  3. Department of Preventive and Rehabilitative Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Cologne, Germany

    Georgina Montiel

  4. Institute for Movement Therapy and Movement Oriented Prevention and Rehabilitation, German Sport University Cologne, Cologne, Germany

    Anke Raabe-Oetker

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  1. Basit Ahmad Dip Sport Sci
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  2. Nina Ferrari PhD Sport Sci
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  3. Georgina Montiel
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  4. Wilhelm Bloch
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Correspondence to Klara Brixius.

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Ahmad, B., Ferrari, N., Montiel, G. et al. Influence of a moderate physical activity intervention on red cell deformability in patients suffering from chronic obstructive pulmonary disease (COPD). Wien Med Wochenschr 163, 334–339 (2013). https://doi.org/10.1007/s10354-013-0183-7

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