Skip to main content
SpringerLink
Log in

Malignant melanoma

Das maligne Melanom

  • Main Topic
  • Published:
European Surgery Aims and scope Submit manuscript

Zusammenfassung

GRUNDLAGEN: Das maligne Melanom ist der Hauttumor mit dem höchsten Malignitätsgrad. In Mitteleuropa beträgt die Inzidenz derzeit 10 bis 15 Fälle je 100.000 Einwohner, weltweit nehmen jedoch die Erkrankungsfälle um 6 % pro Jahr zu. METHODIK: Literaturübersicht zur Diagnose und Therapie des Melanoms. ERGEBNISSE: Diese Arbeit präsentiert die derzeit gültigen Richtlinien bezüglich Klassifikation, Diagnose und Therapie des malignen Melanoms, insbesondere Sentinel-Lymphknoten-Chirurgie und adjuvante Therapie. Entsprechend der Tiefe der Tumorinvasion beträgt das 5-Jahres-Überleben zwischen < 60 und 99 %. SCHLUSSFOLGERUNGEN: Regelmäßiges Screening von Hoch-Risikopatienten und frühe Exzision verdächtiger Tumore spielen eine wichtige Rolle im erfolgreichen Management des malignen Melanoms.

Summary

BACKGROUND: Malignant melanoma is the cutaneous tumour with the highest degree of malignancy. In Central Europe the incidence has risen up to 10–15 cases per 100 000 inhabitants. Worldwide, this malignancy increases by 6 % every year. METHODS: Review of the literature on the diagnosis and therapy of melanoma. RESULTS: The manuscript presents current classification, diagnosis and therapy modalities of melanoma including sentinel lymph node technique and adjuvant therapy. Depending on tumor invasion depth, 5 year survival ranges from < 60–99 %. CONCLUSIONS: Regular screening of high-risk groups and early excision of suspected tumours contribute to successful management of melanoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Anastassiou G, Bornfeld N (2004) Therapie des Aderhautmelanoms. Onkologe 10: 737–744

    Article  Google Scholar 

  • Balch CM, Houghton AN, Milton GW, Sober AJ, Soong S (1992) Cutaneous melanoma. JB Lippincott, Philadelphia

    Google Scholar 

  • Balch CM, Urist MM, Karakousis CP, Smith TJ, Temple WJ, Drzewiecki K, Jewell WR, Bartolucci AA, Mihm CM, Barnhill R, Wanebo HJ (1993) Efficacy of 2 cm surgical margins for intermediate thickness melanomas (1 to 4 mm). Ann Surg 218: 262–269

    PubMed  CAS  Google Scholar 

  • Balch CM, Soong S, Ross MI, Urist MM, Karakousis C, Temple WJ, Mihm MC, Barnhill RL, Jewell WR, Wanebo HJ, Harrison R (2000) Long-term results of a multiinstitutional randomized trial comparing prognostic factors and surgical results for intermediate thickness melanomas (1.0 to 4.0 mm). Intergroup melanoma surgical trial. Ann Surg Oncol 7: 87–97

    Article  PubMed  CAS  Google Scholar 

  • Blum A, Garbe C, Bauer J (2004) Epidemiologie und Risikofaktoren des malignen Melanoms. Onkologe 10: 688–700

    Article  Google Scholar 

  • Breslow A (1970) Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg 172: 902–908

    PubMed  CAS  Google Scholar 

  • Clark WH Jr, From L, Bernardino EA, Mihm MC Jr (1969) The histogenesis and biologic behaviour of primary human malignant melanomas of the skin. Cancer Res 29: 705–727

    PubMed  Google Scholar 

  • Garbe C, Bamberg M (2004) Früherkennung verbessern! Onkologe 10: 683–684

    Google Scholar 

  • Garbe C (2004) Risikoadaptierte Nachsorge des malignen Melanoms. Onkologe 10: 745–750

    Google Scholar 

  • Garbe C, Eigentler TK (2004) Therapie des malignen Melanoms im Stadium der Fernmetastasierung. Hautarzt 55: 195–213

    Article  PubMed  CAS  Google Scholar 

  • Hauschild A, Lischner S, Kähler K (2004) Malignes Melanom: Operative Therapie des Primärtumors. Onkologe 10: 701–709

    Article  Google Scholar 

  • Karakousis CP, Velez A, Driscoll DL, Takita H (1994) Metastasectomy in malignant melanoma. Surgery 115: 295–302

    PubMed  CAS  Google Scholar 

  • Karakousis CP (1996) Surgical treatment of malignant melanoma. Surg Clin North Am 76: 1299–1312

    Article  PubMed  CAS  Google Scholar 

  • Kortmann R-D, Hehr T, Classen J, Paulsen F, Garbe C, Bamberg M (2004) Strahlentherapie des Melanoms. Onkologe 10: 717–728

    Article  Google Scholar 

  • Langley RGB, Barnhill RL, Mihm MC Jr, Fitzpatrick ThB, Sober AJ (1999) Neoplasms: Cutaneous melanoma. In: Freedberg IM, Eisen AZ, Wolff K (eds) Fitzpatrick's dermatology in general medicine. Fifth Edition. McGraw-Hill, Chapter 92, pp 1080–1116

  • Leiter U, Meier F, Schittek B, Garbe C (2004) The natural course of cutaneous melanoma. J Surg Oncol 86: 172–178

    Article  PubMed  Google Scholar 

  • Mack LA, McKinnon G (2004) Controversies in the management of metastatic melanoma to regional lymphatic basins. J Surg Oncol 86: 189–199

    Article  PubMed  Google Scholar 

  • Meyer T, Möhrle M, Garbe C, Hohenberger W (2004) Sentinel Lymph Node beim Melanom. Chirurg 75: 774–780

    PubMed  CAS  Google Scholar 

  • Pehamberger H, Soyer HP, Steiner A, et al. Austrian Malignant Melanoma Cooperative Group (1998) Adjuvant interferon-alpha 2a treatment in resected primary stage II cutaneous melanoma. J Clin Oncol 16: 1425–1429

    PubMed  CAS  Google Scholar 

  • Rath T, Pehamberger H, Koller R, Manfreda D (2001) ACO Schwerpunkt Symposium Melanom – Neue diagnostische und therapeutische Möglichkeiten. Acta Chir Austriaca 33 (Suppl 176)

  • Roses DF (1997) Surgical management of malignant melanoma. In: Grabb-Smith's Plastic Surgery. 5th edition. Lippincott Raven, Philadelphia New York, pp 131–140

    Google Scholar 

  • Schadendorf D, Keilholz U (2004) Medikamentöse Therapie des metastasierten Melanoms im Rahmen prospektiv-randomisierter Studien. Onkologe 10: 729–736

    Article  Google Scholar 

  • Thomas JM, Newton-Bishop J, A'Hern R, Coombes G, Timmons M, Evans J, Cook M, Theaker J, Fallowfield M, O'Neill T, Ruka W, Bliss JM; United Kingdom Melanoma Study Group; British Association of Plastic Surgeons; Scottish Cancer Therapy Network (2004) Excision margins in high-risk malignant melanoma. N Engl J Med 350: 757–766

    Article  PubMed  CAS  Google Scholar 

  • Thompson JF, Scolyer RA, Kefford RF (2005) Cutaneous Melanoma, Seminar. Lancet 365: 687–701

    PubMed  CAS  Google Scholar 

  • Topping A, Dewar D, Rose V, Cavale N, Allen R, Cook M, Powell B (2004) Five years of sentinel node biopsy for melanoma: the St George's Melanoma Unit experience. Brit J Plast Surg 57: 97–104

    Article  PubMed  Google Scholar 

  • Veronesi U, Cascinelli N (1991) Narrow excision (1 cm margin): A safe procedure for thin cutaneous melanoma. Arch Surg 126: 438–441

    PubMed  CAS  Google Scholar 

  • Volkenandt M, Hauschild A, Garbe C (2004) Adjuvante medikamentöse Therapie des malignen Melanoms. Onkologe 10: 710–716

    Article  Google Scholar 

  • Wagner JD, Gordon MS, Chuang T-Y, Coleman JJ (2000) Current therapy of cutaneous melanoma. Plast Reconstr Surg 105: 1774–1799

    Article  PubMed  CAS  Google Scholar 

  • Wick MR, Patterson JW (2005) Sentinel lymph node biopsies for cutaneous melanoma. Surg Pathol 29: 412–414

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria

    T. Rath

Authors
  1. T. Rath
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. Rath.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rath, T. Malignant melanoma. Eur Surg 38, 145–148 (2006). https://doi.org/10.1007/s10353-006-0234-z

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10353-006-0234-z

Schlüsselwörter

Keywords

Search

Navigation