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Survival Stratification Panel of Colorectal Carcinoma with Combined Expression of Carcinoembryonic Antigen, Matrix Metalloproteinases-2, and p27kip1

  • Original Contributions
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Diseases of the Colon & Rectum

Abstract

Purpose

The prognosis varies greatly in colorectal carcinoma patients, even in the same stage. We examined the association between the expression of matrix metalloproteinases-2, carcinoembryonic antigen, p27kip1, and clinicopathologic features in patients with colorectal carcinoma to identify a possible panel of tumor markers in predicting prognosis of colorectal carcinoma.

Methods

The expressions of three individual markers in 127 colorectal carcinoma cases were analyzed by immunohistochemistry method. Univariate and multivariate analysis were performed to analyze the expression with the disease-free survival time in colorectal carcinoma.

Results

High expression of matrix metalloproteinases-2, carcinoembryonic antigen, and low expression of p27kip1 were related to poor prognosis in univariate analysis (P--.0002; P-lt;-.0001; P--.0008). The expression of matrix metalloproteinases-2, carcinoembryonic antigen, p27kip1, and tumor differentiation were independent prognostic factors for disease-free survival by Cox regression analysis. The coexpression panel of matrix metalloproteinases-2, carcinoembryonic antigen, and p27kip had significant prognostic value in all patients (PAB--.0103; PBC--.0068; PCD--.0117). Multivariate analysis with Cox regression reveals that coexpression of matrix metalloproteinases-2, carcinoembryonic antigen, and p27kip1 were independent prognostic factors as tumor differentiation in colorectal carcinoma. In different stages, coexpression tumor markers functioned in Stages II and III but not in the 19 cases of Stage I. The reason might be the number of patients was too small.

Conclusions

The results of this study provided further evidence that the combination of tumor markers of matrix metalloproteinases-2, carcinoembryonic antigen, and p27kip1 was more informative than any single tumor marker alone for the disease-free survival stratification of colorectal carcinoma. Coexpression of matrix metalloproteinases-2, carcinoembryonic antigen, and p27kip1 might be a useful survival stratification panel for clinical management.

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Acknowledgements

The authors thank Drs. Yu Wang, Yun-Tao Xie, Yan-Hua Yuan, Yan Han, Zhen-Dong Gu, and Zhen-Yuan Sun for assistance.

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Authors and Affiliations

  1. Gastrointestinal Surgery Unit, Peking University School of Oncology, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Beijing, People’s Republic of China

    Ming Li M.D., Ph.D. & Jin Gu M.D.

  2. Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Beijing, People’s Republic of China

    Ji-You Li M.D., Ai-Lian Zhao M.D., Jing-Sheng He, Li-Xin Zhou & Ying-Ai Li M.D.

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  1. Ming Li M.D., Ph.D.
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  2. Ji-You Li M.D.
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  3. Ai-Lian Zhao M.D.
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  4. Jing-Sheng He
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  5. Li-Xin Zhou
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  6. Ying-Ai Li M.D.
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  7. Jin Gu M.D.
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Corresponding author

Correspondence to Jin Gu M.D..

Additional information

Supported by the Research fund of the Beijing Municipal Science & Technology Commission (Grant H020920030390); Beijing New Star Project on Science & Technology (Grant 2006B55).

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Li, M., Li, JY., Zhao, AL. et al. Survival Stratification Panel of Colorectal Carcinoma with Combined Expression of Carcinoembryonic Antigen, Matrix Metalloproteinases-2, and p27kip1 . Dis Colon Rectum 50, 1887–1898 (2007). https://doi.org/10.1007/s10350-007-9053-y

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  • DOI: https://doi.org/10.1007/s10350-007-9053-y

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