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Evaluation of the Use of BioGlue® in the Treatment of High Anal Fistulas: Preliminary Results of a Pilot Study

  • Published:
Diseases of the Colon & Rectum

Purpose

Treatment of anal fistulas by use of adhesives is an attractive method because of its simplicity and it can be performed on an ambulatory basis. Furthermore, if the treatment is unsuccessful, adhesive use does not subsequently prevent the surgeon from utilizing alternative surgical techniques and/or products. BioGlue® Surgical Adhesive is a two-component surgical adhesive composed of bovine serum albumin and glutaraldehyde. We evaluated the usefulness of BioGlue® for the treatment of high transsphincter anal fistulas.

Methods

Patients diagnosed with high transsphincter anal fistulas of cryptoglandular origin, whether relapsed or not, were included in this study. A seton was placed before the injection of BioGlue® into the fistula track of high transsphincter anal fistulas in patients with secondary tracts and/or purulent collections. Clinical charts, operative reports, and endoanal echography results obtained for each patient were reviewed.

Results

Fourteen patients (13 males; mean age, 39.9 (range, 24–66) years) with high transsphincter anal fistulas of cryptoglandular origin were recruited into the study. The average time of symptom evolution was 35.6 (range, 2–96) months. Ten of 14 cases were for relapsed fistulas. Six patients required the placement of a seton 37 (range, 32–42) days before the BioGlue® injection. Patients were followed for a mean length of 13.92 (range, 3–21) months, and the fistula healed completely in only seven patients (50 percent).

Conclusions

These preliminary results demonstrate that BioGlue® may be useful for treating patients with high transsphincter anal fistulas. Further prospective long-term studies are needed.

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Acknowledgment

The authors thank Doctor Andrew Zbar for assistance.

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Authors and Affiliations

  1. Coloproctology Unit, Department of General Surgery, Hospital Juan Ramón Jiménez, Ronda Norte s/n, Huelva, 21005, Spain

    Fernando de la Portilla M.D., Ricardo Rada M.D., Nieves Cisneros M.D., Victor Hugo Maldonado M.D. & Eduardo Espinosa M.D.

  2. Department of Internal Medicine, Research Unit, Hospital of Valme, Seville, Spain

    Eva León M.D.

Authors
  1. Fernando de la Portilla M.D.
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  2. Ricardo Rada M.D.
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  3. Eva León M.D.
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  4. Nieves Cisneros M.D.
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  5. Victor Hugo Maldonado M.D.
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  6. Eduardo Espinosa M.D.
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Corresponding author

Correspondence to Fernando de la Portilla M.D..

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de la Portilla, F., Rada, R., León, E. et al. Evaluation of the Use of BioGlue® in the Treatment of High Anal Fistulas: Preliminary Results of a Pilot Study. Dis Colon Rectum 50, 218–222 (2007). https://doi.org/10.1007/s10350-006-0799-4

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  • DOI: https://doi.org/10.1007/s10350-006-0799-4

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