Skip to main content

Advertisement

SpringerLink
Log in

Impact of the Cyclin D1 A870G Polymorphism on Susceptibility to Sporadic Colorectal Cancer in Taiwan

  • Published:
Diseases of the Colon & Rectum

Purpose

Cyclin D1 is a regulatory protein involved in the cell cycle of both normal and neoplastic cells. Polymorphism of this gene at codon 242 in exon 4 has impacts on risk of the early-age onset in several malignant neoplasms, including colorectal cancer. This investigation was designed to evaluate the effect of cyclin D1 gene polymorphism on the risk of colorectal cancer in Chinese migrants of the Taiwanese population.

Methods

We enrolled 831 primary sporadic colorectal cancer patients as the study group and 1,052 age-gender matched healthy individuals as the control group (1,883 total cases) for present study. Cyclin D1 genotypes (AA, AG, GG) were determined using PCR-RFLP analysis on genomic DNA.

Results

The frequency of G allele was 39.89 percent and 40.96 percent in the study group and the control group, respectively (P = 0.02). The patients were divided into three age groups for statistical analysis. The younger male patients had a higher frequency of AA/AG genotype compared with the controls (odds ratio, 2.75; 95 percent confidence interval, 1–7.9). The effect of AA/AG genotype on colorectal cancer risk was statistically significant for male patients (odds ratio, 1.34; 95 percent confidence interval, 1.04–1.72), but suchphenomenon was not observed in female patients.

Conclusions

Our study suggests that the effect of cyclin D1gene polymorphism on colorectal cancer risk is only observed in males and AA/AG genotype of cyclin D1 gene is associated with a higher risk of colorectal cancer in theyounger patients within the Taiwanese population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1

Similar content being viewed by others

References

  1. InstitutionalAuthorNameDepartment of Health (2004) Leading causes of death from cancer, Taiwan area Health Trends and Vital Statistics Department of Health Taipei, Taiwan 73–77

    Google Scholar 

  2. CJ Sherr (1996) ArticleTitleCancer cell cycles Science 274 1672–1677 Occurrence Handle10.1126/science.274.5293.1672 Occurrence Handle1:CAS:528:DyaK28XntlyktLs%3D Occurrence Handle8939849

    Article  CAS  PubMed  Google Scholar 

  3. EA Musgrove CS Lee MF Buckley RL Sutherland (1994) ArticleTitleCyclin D1 induction in breast cancer cells shorten G1 and is sufficient for cells arrested in G1 to complete the cell cycle Proc Natl Acad Sci USA 91 8022–8026 Occurrence Handle1:CAS:528:DyaK2cXlsFCntL0%3D Occurrence Handle8058751

    CAS  PubMed  Google Scholar 

  4. SL Holley G Parkes C Matthias et al. (2001) ArticleTitleCyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck Am J Pathol 159 1917–1924 Occurrence Handle11696452

    PubMed  Google Scholar 

  5. N Arber H Hibshoosh SF Moss et al. (1996) ArticleTitleIncreased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis Gastroenterology 110 669–674 Occurrence Handle10.1053/gast.1996.v110.pm8608874 Occurrence Handle1:CAS:528:DyaK28XhvFCmtLs%3D Occurrence Handle8608874

    Article  CAS  PubMed  Google Scholar 

  6. JA McKay JJ Douglas VG Ross et al. (2000) ArticleTitleCyclin D1 protein expression and gene polymorphism in colorectal cancer. Aberdeen Colorectal Initiative Int J Cancer 88 77–81 Occurrence Handle10.1002/1097-0215(20001001)88:1<77::AID-IJC12>3.0.CO;2-O Occurrence Handle1:CAS:528:DC%2BD3cXmslSntLY%3D Occurrence Handle10964085

    Article  CAS  PubMed  Google Scholar 

  7. DC Betticher N Thatcher HJ Altermatt P Hoban WD Ryder J Heighway (1995) ArticleTitleAlternate splicing produces a novel cyclin D1 transcript Oncogene 11 1005–1011 Occurrence Handle1:CAS:528:DyaK2MXosVyqsrw%3D Occurrence Handle7675441

    CAS  PubMed  Google Scholar 

  8. H Sawa TA Ohshima H Ukita et al. (1998) ArticleTitleAlternatively spliced forms of cyclin D1 modulate entry into the cell cycle in an inverse manner Oncogene 16 1701–1712 Occurrence Handle10.1038/sj.onc.1201691 Occurrence Handle1:CAS:528:DyaK1cXisVKjtL4%3D Occurrence Handle9582018

    Article  CAS  PubMed  Google Scholar 

  9. L Wang T Habuchi T Takahashi et al. (2002) ArticleTitleCyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancer Carcinogenesis 23 257–264 Occurrence Handle10.1093/carcin/23.2.257 Occurrence Handle11872630

    Article  PubMed  Google Scholar 

  10. S Kong CI Amos R Luthra PM Lynch B Levin ML Frazier (2000) ArticleTitleEffects of cyclin D1 polymorphism on age of onset of hereditary nonpolyposis colorectal cancer Cancer Res 60 249–252 Occurrence Handle1:CAS:528:DC%2BD3cXhtVahsrs%3D Occurrence Handle10667569

    CAS  PubMed  Google Scholar 

  11. S Kong Q Wei CI Amos et al. (2001) ArticleTitleCyclin D1 polymorphism and increased risk of colorectal cancer at young age J Natl Cancer Inst 93 1106–1108 Occurrence Handle10.1093/jnci/93.14.1106 Occurrence Handle1:STN:280:DC%2BD3MvgvVWmtA%3D%3D Occurrence Handle11459873

    Article  CAS  PubMed  Google Scholar 

  12. TR Porter FM Richards RS Houlston et al. (2002) ArticleTitleContribution of cyclin D1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer Oncogene 21 1928–1933 Occurrence Handle10.1038/sj.onc.1205245 Occurrence Handle1:CAS:528:DC%2BD38Xis1ahurg%3D Occurrence Handle11896626

    Article  CAS  PubMed  Google Scholar 

  13. S Bala P Peltomaki (2001) ArticleTitleCyclin D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer Cancer Res 61 6042–6045 Occurrence Handle1:CAS:528:DC%2BD3MXmt12kt7o%3D Occurrence Handle11507050

    CAS  PubMed  Google Scholar 

  14. DJ John ParticleSt. FT McDermott JL Hopper EA Debney WR Johnson ES Hughes (1993) ArticleTitleCancer risk in relatives of patients with common colorectal cancer Ann Intern Med 118 785–790

    Google Scholar 

  15. RW Burt (1996) ArticleTitleFamilial risk and colorectal cancer Gastroenterol Clin North Am 25 793–803 Occurrence Handle10.1016/S0889-8553(05)70275-2 Occurrence Handle1:STN:280:ByiC38%2Fit1Y%3D Occurrence Handle8960893

    Article  CAS  PubMed  Google Scholar 

  16. M Shtutman J Zhurinsky I Simcha et al. (1999) ArticleTitleThe cyclin D1 gene is a target of the β-catenin/LEF-1 pathway Proc Natl Acad Sci USA 96 5522–5527 Occurrence Handle10.1073/pnas.96.10.5522 Occurrence Handle1:CAS:528:DyaK1MXjtFCnsbc%3D Occurrence Handle10318916

    Article  CAS  PubMed  Google Scholar 

  17. O Tetsu F McCormick (1999) ArticleTitleβ-Catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 422–426 Occurrence Handle10.1038/18884 Occurrence Handle1:CAS:528:DyaK1MXisFGksrY%3D Occurrence Handle10201372

    Article  CAS  PubMed  Google Scholar 

  18. T Utsunomiya Y Doki H Takemoto et al. (2001) ArticleTitleCorrelation of β-catenin and cyclin D1 expression in colon cancers Oncology 61 226–233 Occurrence Handle10.1159/000055379 Occurrence Handle1:CAS:528:DC%2BD3MXntV2mtb0%3D Occurrence Handle11574779

    Article  CAS  PubMed  Google Scholar 

  19. N Arber Y Doki EK Han et al. (1997) ArticleTitleAntisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells Cancer Res 57 1569–1574 Occurrence Handle1:CAS:528:DyaK2sXis12lsLs%3D Occurrence Handle9108461

    CAS  PubMed  Google Scholar 

  20. L Marchand ParticleLe A Seifried A Lum-Jones T Donlon LR Wilkens (2003) ArticleTitleAssociation of the cyclin D1 A870G Polymorphism with advanced colorectal cancer JAMA 290 2843–2848 Occurrence Handle10.1001/jama.290.21.2843 Occurrence Handle14657069

    Article  PubMed  Google Scholar 

  21. C Matthias K Branigan V Jahnke et al. (1998) ArticleTitlePolymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck Clin Cancer Res 4 2411–2418 Occurrence Handle1:CAS:528:DyaK1cXmvFyktbw%3D Occurrence Handle9796972

    CAS  PubMed  Google Scholar 

  22. RL Kilker MW Hartl TM Rutherford MD Planas-Silva (2004) ArticleTitleCyclin D1 expression is dependent on estrogen receptor function in tamoxifen-resistant breast cancer cells J Steroid Biochem 92 63–71 Occurrence Handle10.1016/j.jsbmb.2004.05.005 Occurrence Handle1:CAS:528:DC%2BD2cXpslWgsrk%3D

    Article  CAS  Google Scholar 

  23. CE Petre-Draviam EB Williams CJ Burd et al. (2005) ArticleTitleA central domain of cyclin D1 mediates nuclear receptor corepressor activity Oncogene 24 431–444 Occurrence Handle10.1038/sj.onc.1208200 Occurrence Handle1:CAS:528:DC%2BD2MXnsFShtQ%3D%3D Occurrence Handle15558026

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan

    Wen-Shih Huang M.D. & Jeng-Yi Wang M.D.

  2. Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan

    Wen-Shih Huang M.D.

  3. Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Medical Center, Taipei, Taiwan

    Reiping Tang M.D., Chung Rong Changchien M.D., Jinn-Shiun Chen M.D., Jy-Ming Chiang M.D. & Chien-Yuh Yeh M.D.

  4. Division of Anatomic Pathology, Department of Pathology, Chang Gung Memorial Hospital, Chiayi, Taiwan

    Paul Y. Lin M.D.

  5. Department of Public Health, Chang Gung University, Taoyuan, Taiwan

    Ling-Ling Hsieh Ph.D.

  6. Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, 6, Sec. West, Chia-Pu Road, Putz City, Chiayi County, Taiwan, 613

    Jeng-Yi Wang M.D.

Authors
  1. Wen-Shih Huang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Reiping Tang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paul Y. Lin M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chung Rong Changchien M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jinn-Shiun Chen M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jy-Ming Chiang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Chien-Yuh Yeh M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jeng-Yi Wang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ling-Ling Hsieh Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jeng-Yi Wang M.D..

Additional information

Reprint requests to: Wen-Shih Huang, M.D., Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, 6, Sec. West, Chia-Pu Road, Putz City, Chiayi County, Taiwan 613, e-mail: wshuang77@hotmail.com

About this article

Cite this article

Huang, WS., Tang, R., Lin, P.Y. et al. Impact of the Cyclin D1 A870G Polymorphism on Susceptibility to Sporadic Colorectal Cancer in Taiwan. Dis Colon Rectum 49, 602–608 (2006). https://doi.org/10.1007/s10350-005-0311-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10350-005-0311-6

Key words

Search

Navigation