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CD10 Expression in Colorectal Carcinoma Correlates With Liver Metastasis

  • Original Contribution
  • Published:
Diseases of the Colon & Rectum

PURPOSE

If it were possible to identify the features of primary colorectal carcinoma that were associated with liver metastasis, these features could be used as predictors of liver metastasis.

METHODS

From January 1995 to December 1997, 648 consecutive cases of colorectal carcinoma were recorded at the Department of Surgery, National Cancer Center Hospital, Tokyo, Japan. We evaluated clinicopathologic and immunohistochemical factors (age, gender, tumor location, gross type, size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and expression of CD10, MUC2, and human gastric mucin) in 505 of these patients who had undergone resection of T2/T3/T4 colorectal carcinomas to clarify the correlation between these factors and liver metastasis.

RESULTS

Liver metastases, including unresectable, were detected in 122 patients (24 percent), all of whom had been followed for at least five years. Univariate analysis revealed that liver metastasis was significantly associated with tumor size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and CD10 expression. Multivariate analysis revealed that invasion deeper than the subserosa, venous invasion, lymph-node metastasis, and CD10 expression were significantly associated with liver metastases.

CONCLUSIONS

CD10 expression in colorectal carcinoma is a good predictor of liver metastasis.

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Authors and Affiliations

  1. Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan

    Yoshiya Fujimoto M.D. & Tadakazu Shimoda M.D.

  2. Department of Surgery, National Cancer Center Hospital, Tokyo, Japan

    Yoshiya Fujimoto M.D., Takayuki Akasu M.D. & Yoshihiro Moriya M.D.

  3. Pathology Division, National Cancer Center Research Institute, Tokyo, Japan

    Yukihiro Nakanishi M.D. & Shigeki Sekine M.D.

  4. Cancer Information and Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan

    Kimio Yoshimura M.D.

Authors
  1. Yoshiya Fujimoto M.D.
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  2. Yukihiro Nakanishi M.D.
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  3. Shigeki Sekine M.D.
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  4. Kimio Yoshimura M.D.
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  5. Takayuki Akasu M.D.
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  6. Yoshihiro Moriya M.D.
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  7. Tadakazu Shimoda M.D.
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Corresponding author

Correspondence to Tadakazu Shimoda M.D..

Additional information

Supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labor and Welfare, Japan.

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Fujimoto, Y., Nakanishi, Y., Sekine, S. et al. CD10 Expression in Colorectal Carcinoma Correlates With Liver Metastasis. Dis Colon Rectum 48, 1883–1889 (2005). https://doi.org/10.1007/s10350-005-0141-6

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  • DOI: https://doi.org/10.1007/s10350-005-0141-6

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