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Systemic and Peritoneal Angiogenic Response After Laparoscopic or Conventional Colon Resection in Cancer Patients: A Prospective, Randomized Trial

  • Original Contributions
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Diseases of the Colon & Rectum

PURPOSE

Angiogenesis is essential for wound healing. Vascular endothelial growth factor and endostatin are both endogenous angiogenic factors thought to be involved in the initiation and termination of angiogenesis. The aim of this study was to assess the local and systemic angiogenic profile in patients undergoing laparoscopic or open surgery for colon cancer.

METHODS

Patients with primary colon carcinoma were prospectively randomized to curative laparoscopic (n = 12) or conventional (n = 14) resection. Vascular endothelial growth factor and endostatin levels in serum and wound fluid were investigated.

RESULTS

In both groups vascular endothelial growth factor levels in wound fluid were significantly higher than postoperative serum levels, whereas endostatin levels in wound fluid were lower than serum levels and decreased progressively after surgery. The vascular endothelial growth factor levels in wound fluid measured at Day 4 were significantly higher in the laparoscopy group than in the laparotomy patients.

CONCLUSIONS

Wound healing is associated with a strong local increase in pro-angiogenic factors and a decrease in antiangiogenic factors. The investigation of locally produced factors offered greater insight into the process of angiogenesis during wound healing than could be acquired from the circulation.

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REFERENCES

  1. AJ Singer RA Clark (1999) ArticleTitleCutaneous wound healing N Engl J Med 341 738–46 Occurrence Handle10.1056/NEJM199909023411006 Occurrence Handle1:CAS:528:DyaK1MXmtVyrurY%3D Occurrence Handle10471461

    Article  CAS  PubMed  Google Scholar 

  2. SE Lynch (1991) ArticleTitleInteractions of growth factors in tissue repair Prog Clin Biol Res 365 341–57 Occurrence Handle1:CAS:528:DyaK3MXltlarsrk%3D Occurrence Handle1713697

    CAS  PubMed  Google Scholar 

  3. G Neufeld T Cohen S Gengrinovitch Z Poltorak (1999) ArticleTitleVascular endothelial growth factor (VEGF) and its receptors FASEB J 13 9–22 Occurrence Handle1:CAS:528:DyaK1MXlt1ygsQ%3D%3D Occurrence Handle9872925

    CAS  PubMed  Google Scholar 

  4. S Esser K Wolburg H Wolburg et al. (1998) ArticleTitleVascular endothelial growth factor induces endothelial fenestrations in vitro J Cell Biol 140 947–59 Occurrence Handle10.1083/jcb.140.4.947 Occurrence Handle1:CAS:528:DyaK1cXhtlegtbs%3D Occurrence Handle9472045

    Article  CAS  PubMed  Google Scholar 

  5. TR Howdieshell D Callaway WL Webb et al. (2001) ArticleTitleAntibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation J Surg Res 96 173–82 Occurrence Handle10.1006/jsre.2001.6089 Occurrence Handle1:CAS:528:DC%2BD3MXitFChsbw%3D Occurrence Handle11266270

    Article  CAS  PubMed  Google Scholar 

  6. K Werther IJ Christensen N Brunner HJ Nielsen (2000) ArticleTitleSoluble vascular endothelial growth factor levels in patients with primary colorectal carcinoma. The Danish RANX05 Colorectal Cancer Study Group Eur J Surg Oncol 26 657–62 Occurrence Handle10.1053/ejso.2000.0977 Occurrence Handle1:STN:280:DC%2BD3M%2Fms1SqtQ%3D%3D Occurrence Handle11078612

    Article  CAS  PubMed  Google Scholar 

  7. D Schuppan T Cramer M Bauer et al. (1998) ArticleTitleHepatocytes as a source of collagen type XVIII endostatin Lancet 352 879–80 Occurrence Handle1:STN:280:DyaK1cvhtl2itQ%3D%3D Occurrence Handle9742985

    CAS  PubMed  Google Scholar 

  8. K Kuroi C Tanaka M Toi (2001) ArticleTitleCirculating levels of endostatin in cancer patients Oncol Rep 8 405–9 Occurrence Handle1:CAS:528:DC%2BD3MXit1anu7o%3D Occurrence Handle11182064

    CAS  PubMed  Google Scholar 

  9. M Dhanabal R Ramchandran MJ Waterman et al. (1999) ArticleTitleEndostatin induces endothelial cell apoptosis J Biol Chem 274 11721–6 Occurrence Handle10.1074/jbc.274.17.11721 Occurrence Handle1:CAS:528:DyaK1MXislGlsrk%3D Occurrence Handle10206987

    Article  CAS  PubMed  Google Scholar 

  10. SS Yoon H Eto CM Lin et al. (1999) ArticleTitleMouse endostatin inhibits the formation of lung and liver metastases Cancer Res 59 6251–6 Occurrence Handle1:CAS:528:DC%2BD3cXktFynsw%3D%3D Occurrence Handle10626820

    CAS  PubMed  Google Scholar 

  11. T Kloosterman BM Blomberg Particlevon P Borgstein MA Cuesta RJ Scheper S Meijer (1994) ArticleTitleUnimpaired immune functions after laparoscopic cholecystectomy Surgery 115 424–8 Occurrence Handle1:STN:280:ByuB3MfnvVY%3D Occurrence Handle8165532

    CAS  PubMed  Google Scholar 

  12. C Sietses MJ Wiezer QA Eijsbouts et al. (1999) ArticleTitleA prospective randomized study of the systemic immune response after laparoscopic and conventional Nissen fundoplication Surgery 126 5–9 Occurrence Handle10.1067/msy.1999.98702 Occurrence Handle1:STN:280:DyaK1MzkslWguw%3D%3D Occurrence Handle10418585

    Article  CAS  PubMed  Google Scholar 

  13. FP Wu C Sietses BM Blomberg Particlevon PA Vanleeuwen S Meijer MA Cuesta (2003) ArticleTitleSystemic and peritoneal Inflammatory response after laparoscopic or conventional colon resection in cancer patients Dis Colon Rectum 46 147–55

    Google Scholar 

  14. AM Lacy JC Garcia Valdecasas S Delgado et al. (2002) ArticleTitleLaparoscopic assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomized trial Lancet 359 2224–9 Occurrence Handle10.1016/S0140-6736(02)09290-5 Occurrence Handle12103285

    Article  PubMed  Google Scholar 

  15. T Cohen D Nahari LW Cerem et al. (1996) ArticleTitleInterleukin 6 induces the expression of vascular endothelial growth factor J Biol Chem 271 736–41 Occurrence Handle10.1074/jbc.271.2.736 Occurrence Handle1:STN:280:BymC3s3otVU%3D Occurrence Handle8557680

    Article  CAS  PubMed  Google Scholar 

  16. P Salven A Orpana H Joensuu (1999) ArticleTitleLeukocytes and platelets of patients with cancer contain high levels of vascular endothelial growth factor Clin Cancer Res 5 487–91 Occurrence Handle1:STN:280:DyaK1M7pvVOqtA%3D%3D Occurrence Handle10100697

    CAS  PubMed  Google Scholar 

  17. DA Elson HE Ryan JW Snow et al. (2000) ArticleTitleCoordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing Cancer Res 60 6189–95 Occurrence Handle1:CAS:528:DC%2BD3cXotV2ltr4%3D Occurrence Handle11085544

    CAS  PubMed  Google Scholar 

  18. JE Ohm DP Carbone (2001) ArticleTitleVEGF as a mediator of tumor-associated immunodeficiency Immunol Res 23 263–72 Occurrence Handle10.1385/IR:23:2-3:263 Occurrence Handle1:CAS:528:DC%2BD3MXltFWqtro%3D Occurrence Handle11444391

    Article  CAS  PubMed  Google Scholar 

  19. DI Gabrilovich HL Chen KR Girgis et al. (1996) ArticleTitleProduction of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells Nat Med 2 1096–103 Occurrence Handle10.1038/nm1096-1096 Occurrence Handle1:CAS:528:DyaK28Xmt1Wnu7o%3D Occurrence Handle8837607

    Article  CAS  PubMed  Google Scholar 

  20. P Taura A Lopez AM Lacy et al. (1998) ArticleTitleProlonged pneumoperitoneum at 15 mm Hg causes lactic acidosis Surg Endosc 12 198–201 Occurrence Handle10.1007/s004649900633 Occurrence Handle1:STN:280:DyaK1c7mvFGltg%3D%3D Occurrence Handle9502694

    Article  CAS  PubMed  Google Scholar 

  21. D Arcangelo F Facchiano LM Barlucchi et al. (2000) ArticleTitleAcidosis inhibits endothelial cell apoptosis and function and induces basic fibroblast growth factor and vascular endothelial growth factor expression Circ Res 86 312–8 Occurrence Handle10679483

    PubMed  Google Scholar 

  22. S Arumugum YC Jang C Chen-Jensen et al. (1999) ArticleTitleTemporal activity of plasminogen activators and matrix metalloproteinases during cutaneous wound repair Surgery 125 587–93 Occurrence Handle10.1067/msy.1999.98254 Occurrence Handle10372023

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, VU Medisch Centrum, Amsterdam, The Netherlands

    F. P. K. Wu M.D., C. Sietses M.D., Ph.D., S. Meijer M.D., Ph.D. & M. A. Cuesta M.D., Ph.D.

  2. Department of Medical Oncology, VU Medisch Centrum, Amsterdam, The Netherlands

    K. Hoekman M.D., Ph.D.

  3. Department of Pathology and Immunology, VU Medisch Centrum, Amsterdam, The Netherlands

    B. M. E. von Blomberg Ph.D.

  4. Department of Surgery, Dijkzigt Ziekenhuis, Rotterdam, The Netherlands

    H. J. Bonjer M.D., Ph.D.

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  1. F. P. K. Wu M.D.
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  2. K. Hoekman M.D., Ph.D.
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  3. C. Sietses M.D., Ph.D.
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  4. B. M. E. von Blomberg Ph.D.
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  5. S. Meijer M.D., Ph.D.
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  6. H. J. Bonjer M.D., Ph.D.
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  7. M. A. Cuesta M.D., Ph.D.
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Corresponding author

Correspondence to M. A. Cuesta M.D., Ph.D..

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Wu, F., Hoekman, K., Sietses, C. et al. Systemic and Peritoneal Angiogenic Response After Laparoscopic or Conventional Colon Resection in Cancer Patients: A Prospective, Randomized Trial. Dis Colon Rectum 47, 1670–1674 (2004). https://doi.org/10.1007/s10350-004-0660-6

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  • DOI: https://doi.org/10.1007/s10350-004-0660-6

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