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Translation Modification Iteration for Resolution and Quantification of Overlapping Chromatographic Peaks

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Abstract

A novel algorithm, translation modification iteration (TMI), is proposed for resolving overlapping chromatographic peaks. By this method, a series of similar peaks are obtained from the initial construction of single component peaks and approach the profiles of real single component peaks by iteration. Both simulated and experimental data are investigated with TMI, consequently overlapping peaks can be resolved into reasonable single component peaks easily and efficiently. Quantitative analysis is also successfully achieved in both simulated and experimental data, and the quantitative results obtained from TMI are superior to those obtained from perpendicular drop (PD) and tangent skim (TS) methods. Without too much time devoted to the procedure, TMI is a simple and practicable method for resolution and quantification of overlapping chromatographic peaks.

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Authors and Affiliations

  1. School of Material Science and Engineering, Tianjin University, Tianjin, 300072, China

    Hongru Liu, Zhengji Pang & Guoliang Fan

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  1. Hongru Liu
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  2. Zhengji Pang
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  3. Guoliang Fan
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Correspondence to Guoliang Fan.

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Liu, H., Pang, Z. & Fan, G. Translation Modification Iteration for Resolution and Quantification of Overlapping Chromatographic Peaks. Chromatographia 79, 1543–1552 (2016). https://doi.org/10.1007/s10337-016-3172-3

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  • DOI: https://doi.org/10.1007/s10337-016-3172-3

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