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Separation of Isomers on Nematic Liquid Crystal Stationary Phases in Gas Chromatography: A Review

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Abstract

Understanding the composition of complex hydrocarbon mixtures is important for environmental studies in diverse fields, but many prevalent compounds cannot be confidently identified using traditional gas chromatography (GC) techniques. Increasing requirements on analyses of isomeric compounds and the problems encountered in their separation demand a study of more efficient systems which exhibit a high selectivity. Kelker and Fresenius first used nematic liquid crystals as stereospecific stationary phases in GC. Nematic liquid crystal has shown this particular selectivity and sensitivity as stationary phases for the separation of isomers having similar volatilities. Because of their unique selectivity towards rigid solute isomers, liquid crystal stationary phases were considered at one time to be a very promising class of materials that give gas chromatographic separations very different from those that can be obtained with any other stationary phase. Since then, a great deal of attention has been paid to the separation properties of this relatively wide group of substances. Liquid crystal can be used to separate a variety of compounds including isomer mixtures which cannot be separated on conventional stationary phases. This paper aims to review all specific experimental results and presents a comparative analytical study of monomeric nematic liquid crystal stationary phases used in GC. A further contribution of this review is in the field of isomeric compounds separation.

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Notes

  1. Mesophase: is a state of matter intermediate between liquid and solid.

References

  1. Megharaj M, Ramakrishnan B, Venkateswarlu K, Sethunathan N, Naidu R (2011) Environ Int 37:1362–1375

    Article  CAS  Google Scholar 

  2. Simoneit BR (2005) Mass Spectrom Rev 24:719–765

    Article  CAS  Google Scholar 

  3. Fraser MP, Lakshmanan K (2000) Environ Sci Technol 34:4560–4564

    Article  CAS  Google Scholar 

  4. Mazurek MA (2002) Environ Health Perspect 110:995–1003

    Article  CAS  Google Scholar 

  5. Schauer JJ, Rogge WF, Hildemann LM, Mazurek MA, Cass GR (1996) Atmos Environ 30:3837–3855

    Article  CAS  Google Scholar 

  6. Williams BJ, Goldstein AH, Kreisberg NM, Hering SV, Worsnop DR, Ulbrich IM, Docherty KS, Jimenez JL (2010) Atmos Chem Phys 10:11577–11603

    Article  CAS  Google Scholar 

  7. Zielinski WL Jr (1987) CRC handbook of chromatography: hydrocarbons, vol 1. Gas chromatography. CRC Press, Inc., Boca Raton

  8. Naikwadi KP, Wadgaonkar PP (1998) J Chromatogr A 811(1–2):97

    Article  CAS  Google Scholar 

  9. Cook LE, Spangelo RC (1974) Anal Chem 46(1):122–126

    Article  CAS  Google Scholar 

  10. Zielinski WL Jr, Janini GM (1979) J Chromatogr A 186:237–247

    Article  CAS  Google Scholar 

  11. Rotzsche H (1991) Stationary phases in gas chromatography. J Chromatogr Library, vol 48. Elsevier, Amsterdam

  12. Witkiewicz Z (1982) J Chromatogr 251:311

    Article  CAS  Google Scholar 

  13. Witkiewicz Z (1989) J Chromatogr A 466:37

    Article  CAS  Google Scholar 

  14. Witkiewicz Z (1991) Liquid crystals: applications and uses. World Scientific Publishing, Singapore

    Google Scholar 

  15. Witkiewicz Z, Mazur J (1990) Liq Chromatogr Gas Chromatogr 8:224

    CAS  Google Scholar 

  16. Kelker H (1963) Z Anal Chem 198:254–266. doi:10.1007/BF00486441

    Article  CAS  Google Scholar 

  17. Kelker H, Von Schivizhoffen E (1968) Advances in chromatography, vol 6. Marcel Dekker, New York, pp 247–297

    Google Scholar 

  18. Dewar MJS, Schroeder JP (1964) J Am Chem Soc 86:5235–5239. doi:10.1021/ja01077a039

    Article  CAS  Google Scholar 

  19. Perez F, Berdague P, Bayle JP, Courtieu J, Boudah S, Guermouche MH (1997) J High Resolut Chromatogr 20:379–384

    Article  CAS  Google Scholar 

  20. Gritti F, Felix G (2002) Chromatographia 55:523

    Article  CAS  Google Scholar 

  21. Witkiewicz Z, Oszczudłowski J, Repelewicz M (2003) Chem Anal (Warsaw) 48:397

    CAS  Google Scholar 

  22. Witkiewicz Z (2005) J Chromatogr A 1062:155–174

    Article  CAS  Google Scholar 

  23. Ali MHA-M, Al-Haidary AA, Al-Mehdaoui MTS (2003) Turk J Chem 27:259–264

    CAS  Google Scholar 

  24. Benalia M et al (2007) Asian J Chem 19(3):1761–1771

    CAS  Google Scholar 

  25. Belaïdi D, Sebih S, Guermouche MH, Bayle JP, Boudah S (2002) C R Chimie 5:591–598

    Article  Google Scholar 

  26. Dahmane M, Athman F, Sebih S, Guermouche MH, Bayle JP, Boudah S (2009) Chromatographia 70:489–495

    Article  CAS  Google Scholar 

  27. Ghanem E, Al-Hariri S (2013) Aust J Basic Appl Sci 7(6):135–141

    CAS  Google Scholar 

  28. Janini GM (1982) Advances in chromatography, vol 17. Marcel Dekker, New York, pp 231–277

    Google Scholar 

  29. Betts TJ (1993) J Chromatogr A 641:189–193. doi:10.1016/0021-9673(93)83475-8

    Article  CAS  Google Scholar 

  30. Gritti F, Félix G, Achard MF, Hardouin F (2000) J Chromatogr A 893:359–366

    Article  CAS  Google Scholar 

  31. Weiss RG (1988) Tetrahedron 44:3413

    Article  CAS  Google Scholar 

  32. Mossner SG, Lopez de Alda MJ, Sander LC, Lee ML, Wise SA (1999) J Chromatogr A 841:207–228. doi:10.1016/S0021-9673(99)00363-5

    Article  CAS  Google Scholar 

  33. Sander LC, Schneider M, Wise SA, Woolley C (1994) J Microcol Sep 6:115–125

    Article  CAS  Google Scholar 

  34. Poole CF (2003) The essence of chromatography. Elsevier Science, Amsterdam, p 839

    Google Scholar 

  35. Pekay LA, Olesik SV (1989) Anal Chem 61:58

    Article  Google Scholar 

  36. Chang HCK, Taylor LT (1990) J Chromatogr 28:29

    CAS  Google Scholar 

  37. Bornhop DJ, Murphy BJ (1989) Anal Chem 61:797

    Article  CAS  Google Scholar 

  38. Sojak L, Osrovsky I (1988) J Chromatogr 446:339

    Article  CAS  Google Scholar 

  39. Krauss G, Theirfelder JM, Sojak L (1994) J Chromatogr 677:197

    Article  Google Scholar 

  40. Sojak L, Kraus G, Farkas P, Osrovsky I (1982) J Chromatogr 249:29

    Article  CAS  Google Scholar 

  41. Berdagué P, Bayle JP, Perez F, Courtieu J, Abdelhadi O, Guermouche S, Guermouche MH (1995) Chromatographia 40:581

    Article  Google Scholar 

  42. Haky JE, Muschik GM (1981) J Chromatogr 214:161

    Article  CAS  Google Scholar 

  43. Mioshioka M, Jones BA, Tarbet BJ, Bradshaw S, Lee MJ (1986) J Chromatogr 375:79

    Google Scholar 

  44. Ghatge BB, Balerao VJ (1991) J Chromatogr 549:423

    Article  CAS  Google Scholar 

  45. Khodja FA, Guermouche S, Guermouche MH (1999) Chromatographia 50:338

    Article  Google Scholar 

  46. Betts TJ (1992) J Chromatogr 605:276

    Article  CAS  Google Scholar 

  47. Betts TJ (1992) J Chromatogr 626:294

    Article  CAS  Google Scholar 

  48. Boudah S, Sebih S, Guermouche MH, Rogalski M, Bayle JP (2003) Chromatographia Suppl. 57:307

    Article  Google Scholar 

  49. Naikwadi KP, Pause DG, Bapat BV, Ghatge BB (1981) J Chromatogr 206:361

    Article  CAS  Google Scholar 

  50. Bélaidi D, Sébih S, Guermouche MH, Bayle JP, Boudah S (2003) Chromatographia Suppl. 57:207

    Article  Google Scholar 

  51. Sakagami S, Nakamizo M (1984) Bull Chem Soc Jpn 57:1157–1158

    Article  CAS  Google Scholar 

  52. Berdagué P, Bayle JP et al (1995) J High Resolut Chromatogr 18(5):304

    Article  Google Scholar 

  53. Wasik SJ (1976) J Chromatogr 122:451

    Article  CAS  Google Scholar 

  54. Berdagué P, Perez F, Bayle JP, Courtieu J, Boudah S, Sebih S, Guermouche MH (1996) Bull Soc Chim Fr 133:427–433

    Google Scholar 

  55. Perez F, Berdague P, Courtieu J, Bayle JP, Boudah S, Guermouche MH (1996) J Chromatogr A 746:247

    Article  CAS  Google Scholar 

  56. Breckler PN, Betts TJ (1970) J Chromatogr 53:163

    Article  CAS  Google Scholar 

  57. Maier W, Saupe A (1960) Z Naturforsch 15A: 287 and preceding articles by the same authors

  58. Chambers M, Clemitson R, Coates D, Greenfiled S, Jenner JA, Sage IC (1989) Liq Cryst 5(1):153

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors thank Damascus University for financial support, and special thanks to Chemistry Department, Faculty of Sciences.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Damascus University, Damascus, Syrian Arab Republic

    Emad Ghanem & Sahar Al-Hariri

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  1. Emad Ghanem
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  2. Sahar Al-Hariri
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Correspondence to Emad Ghanem.

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Ghanem, E., Al-Hariri, S. Separation of Isomers on Nematic Liquid Crystal Stationary Phases in Gas Chromatography: A Review. Chromatographia 77, 653–662 (2014). https://doi.org/10.1007/s10337-014-2675-z

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