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Models for Liquid–Liquid Partition in the System Ethylene Glycol–Organic Solvent and Their Use for Estimating Descriptors for Organic Compounds

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Abstract

Partition coefficients for varied compounds were determined for the ethylene glycol–organic solvent biphasic partition system where the organic solvent is n-heptane, 1,2-dichloroethane or isopentyl ether. These partition coefficient databases are analyzed using the solvation parameter model facilitating a quantitative comparison of the ethylene glycol-based partition systems with other totally organic partition systems. Ethylene glycol is a cohesive solvent, reasonably dipolar/polarizable, strongly hydrogen-bond basic, and moderately hydrogen-bond acidic. Ethylene glycol–organic solvent systems offer a complementary approach to other totally organic biphasic partition systems for sample preparation and descriptor measurements of compounds virtually insoluble in water.

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Authors and Affiliations

  1. Department of Chemistry, Rm 181 Chemistry, Wayne State University, Detroit, MI, 48202, USA

    Thushara Karunasekara & Colin F. Poole

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  1. Thushara Karunasekara
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  2. Colin F. Poole
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Correspondence to Colin F. Poole.

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Karunasekara, T., Poole, C.F. Models for Liquid–Liquid Partition in the System Ethylene Glycol–Organic Solvent and Their Use for Estimating Descriptors for Organic Compounds. Chromatographia 73, 941–951 (2011). https://doi.org/10.1007/s10337-011-1996-4

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  • DOI: https://doi.org/10.1007/s10337-011-1996-4

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