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Functional MRI at 3T using intermolecular double-quantum coherence (iDQC) with spin-echo (SE) acquisitions

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Abstract

Object

To reinvestigate the dependence of the signal and contrast on sequence parameters and tissue relaxation times for intermolecular double-quantum coherence (iDQC) signals, and to explore the possibility to use a spin-echo (SE)-iDQC sequence for detecting activation signals at 3T.

Materials and methods

Brain activations were detected in five human volunteers in a visual simulation study using a SE-iDQC sequence, in addition to a GE-iDQC and a conventional single-quantum coherence (SQC) blood-oxygenation-level-dependent (BOLD) sequence. A brain phantom was also used for some quantitative measurements.

Results

By choosing an optimal echo time TE (~T2) and iDQC evolution time τ(~20 ms), robust brain activations were detected using the SE-iDQC sequence, in addition to the GE-iDQC and a conventional single-quantum coherence (SQC) BOLD sequence. A higher percentage signal change due to activation was observed for both the iDQC-based measurements in comparison to the conventional SQC acquisition.

Conclusion

Even though a phenomenological analysis consistent with the experimental results was provided, a detailed model is still needed for the contrast mechanism at microscopic level to guide potential applications of brain functional imaging based on the SE-iDQC.

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Authors and Affiliations

  1. Department of Imaging Sciences, University of Rochester, Rochester, NY, 14642, USA

    T. Gu, Z. Chen & J. Zhong

  2. Rochester Center for Brain Imaging, University of Rochester, Rochester, NY, 14642, USA

    T. Gu, K. A. Schneider & J. Zhong

  3. Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY, 14642, USA

    S. D. Kennedy

  4. Department of Visual Science, University of Rochester, Rochester, NY, 14642, USA

    K. A. Schneider

  5. Department of Imaging Sciences, School of Medicine and Dentistry, University of Rochester, Box 648, Elmwood Avenue, Rochester, NY, 14642-8648, USA

    J. Zhong

Authors
  1. T. Gu
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  2. S. D. Kennedy
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  3. Z. Chen
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  4. K. A. Schneider
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  5. J. Zhong
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Corresponding author

Correspondence to J. Zhong.

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Gu, T., Kennedy, S.D., Chen, Z. et al. Functional MRI at 3T using intermolecular double-quantum coherence (iDQC) with spin-echo (SE) acquisitions. Magn Reson Mater Phy 20, 255–264 (2007). https://doi.org/10.1007/s10334-007-0093-z

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  • DOI: https://doi.org/10.1007/s10334-007-0093-z

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