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A study on the overexpression of microRNAs and lung cancer

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

MicroRNAs (miRNAs), which contains approximately 22 nt, belong to a small endogenous, non-coding regulatory single-stranded RNA molecules. They are posttranscriptional regulators of gene expression and highly conserved in evolution. Many researches show that miRNAs involved in many processes, including tumor formation, cell proliferation and apoptosis and proliferation and metastasis of cancer cells. Among that, the relationship between miRNAs and lung cancer is one of the most focal areas for the researchers, because the abnormal expressions of miRNAs were significantly associated with the occurrence and development of lung cancer. The expression level of different miRNAs in lung cancer cells exist differences, compared with normal lung tissue cells, there are two classes of expression: over-expression level and low expression level. In this review, we focused on studying the mechanism of overexpression miRNAs in lung cancer.

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Authors and Affiliations

  1. Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, Yunnan University, Kunming, 650091, China

    Longfeng Xu, Chun Hou & Qishun Zhu

  2. Cancer Institute, The Thirrd Affiliated Hospital of Kunming Medical University, Kunming, 650118, China

    Zhiping Wu & Yan Chen

  3. The Fifth High School of Guandu District, Kunming, 650011, China

    Rui Feng

  4. Department of Base Medicine, Yunnan Chinese Traditional Medical College, Kunming, 650200, China

    Fan Yang & Qishun Zhu

Authors
  1. Longfeng Xu
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  2. Zhiping Wu
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  3. Yan Chen
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  4. Rui Feng
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  5. Chun Hou
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  6. Fan Yang
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  7. Qishun Zhu
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Correspondence to Qishun Zhu.

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Xu, L., Wu, Z., Chen, Y. et al. A study on the overexpression of microRNAs and lung cancer. Chin. -Ger. J. Clin. Oncol. 12, 443–447 (2013). https://doi.org/10.1007/s10330-013-1199-6

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  • DOI: https://doi.org/10.1007/s10330-013-1199-6

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