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Research of the relationship between radiotherapy and microRNAs

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

MicroRNAs (miRNAs) are endogenous short non-coding RNAs, and play a pivotal role in regulating a variety of cellular processes, including proliferation and apoptosis, both of which are cellular responses to radiation treatment. In response to radiation, multiple miRNAs show altered expression, which act as oncogenes or tumor suppressors. Recent evidence has also shown that some miRNAs have radiotherapy sensitization or radiation resistance role in malignant tumors. This review focuses on analysis of these characteristics and mechanisms of miRNAs, and will provide some insight into the therapeutic application of radiation.

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Authors and Affiliations

  1. Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China

    Jiao Yang & Ximing Xu

  2. Cancer Center, People’s Hospital of Guangxi Autonomous Region, Nanning, 530000, China

    Yanrong Hao

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  1. Jiao Yang
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  2. Ximing Xu
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  3. Yanrong Hao
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Correspondence to Ximing Xu or Yanrong Hao.

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Yang, J., Xu, X. & Hao, Y. Research of the relationship between radiotherapy and microRNAs. Chin. -Ger. J. Clin. Oncol. 11, 285–289 (2012). https://doi.org/10.1007/s10330-012-0972-2

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  • DOI: https://doi.org/10.1007/s10330-012-0972-2

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