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A non-synonymous coding SNP Lys45Glu of mmp3 associated with ESCC genetic susceptibility in population of Henan, China

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

The aim of the study was to investigate the association of esophageal squamous cell carcinoma (ESCC) genetic susceptibility with the single nucleotide polymorphism (SNP) rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene, and the population in high incidence region of Henan (China) was selected for exploring the mechanism by case-control study.

Methods

The mmp3 SNP was genotyped by PCR-RFLP analysis in total 605 cases of Henan population, in which there were 227 ESCC cases and 197 controls of An-yang in Henan plus 181 controls of emigrants in Hubei from Xi-chuan of Henan, China.

Results

The statistic data showed that G/G and G/A genotype frequencies of SNP rs679620 were significantly different between the controls of emigrants of Xi-chuan in Hubei and controls of An-yang in Henan (P < 0.01) also the ESCC cases of An-yang in Henan (P < 0.01), respectively.

Conclusion

This study suggests that the SNP rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene might be associated with ESCC genetic susceptibility.

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Authors and Affiliations

  1. College of Life Science, South-Central University for Nationalities, Wuhan, 430074, China

    Gang Ouyang, Wenjuan Hu, Hong Wang & Jin Li

  2. Hubei Tumour Hospital, Wuhan, 430079, China

    Pinfang Yao & Qingbo Chen

  3. Lab for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou, 450052, China

    Lidong Wang

Authors
  1. Gang Ouyang
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  2. Pinfang Yao
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  3. Wenjuan Hu
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  4. Qingbo Chen
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  5. Hong Wang
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  6. Lidong Wang
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  7. Jin Li
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Corresponding author

Correspondence to Jin Li.

Additional information

Supported by a grant from the Natural Sciences Foundation of State Ethnic Affairs Commission of China (No. 07ZN09).

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Ouyang, G., Yao, P., Hu, W. et al. A non-synonymous coding SNP Lys45Glu of mmp3 associated with ESCC genetic susceptibility in population of Henan, China. Chin. -Ger. J. Clin. Oncol. 8, 510–515 (2009). https://doi.org/10.1007/s10330-009-0131-6

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  • DOI: https://doi.org/10.1007/s10330-009-0131-6

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