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Clinical outcome following radical hysterectomy and pelvic lymphadenectomy for early-stage cervical cancer

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The Chinese-German Journal of Clinical Oncology

Abstract

Objective

To estimate the impact of parametrial infiltration and lymph node metastasis on clinical outcome in women with early-stage cervical cancer following radical hysterectomy and pelvic lymphadenectomy.

Methods

Clinical records and pathologic slides of 532 patients with early-stage cervical cancer (330 Ib and 202 IIa) treated with radical hysterectomy and pelvic lymphadenectomy were reviewed. The study group comprised 520 patients with squamous cell carcinoma and 12 patients with adenocarcinoma of the cervix. Median follow-up time was 67 months. The association among the various histopathologic predictors of outcome was determined with analysis. The influence of the predictors on outcome was examined with log rank survival methods and the Cox regression model.

Results

FIGO stage, histologic type, tumor size, depth of invasion, parametrial infiltration, lymph node metastasis, and remote metastasis were identified as significantly biologically relevant and therefore were included as candidate predictors in multivariate analysis. In particular, parametrial infiltration and lymph node metastasis were found to be simultaneous predictors of death on multivariate analysis (P < 0.05). After controlling for these two factors, the other variables considered were not statistically significant up to a two-way interaction.

Conclusion

Presence of parametrial infiltration and/or lymph node metastasis in women with early-stage cervical cancer is an independent poor prognostic factor. In addition, the relatively poor survival of women with more than one lymph nodes identified with cancer cells.

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Authors and Affiliations

  1. Dept of OB/GYN, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Hongbo Wang & Zehua Wang

  2. Dept of OB/GYN, The Affiliated Hospital of Shanxi Medical University, Taiyuan, 230022, China

    Suhui Wu

Authors
  1. Hongbo Wang
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  2. Suhui Wu
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  3. Zehua Wang
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Corresponding author

Correspondence to Hongbo Wang.

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Wang, H., Wu, S. & Wang, Z. Clinical outcome following radical hysterectomy and pelvic lymphadenectomy for early-stage cervical cancer. Chin. -Ger. J. Clin. Oncol. 7, 723–727 (2008). https://doi.org/10.1007/s10330-008-0122-z

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  • DOI: https://doi.org/10.1007/s10330-008-0122-z

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