Abstract
Objective
To systematically analyze and summarize non-thyrogenous masses of the neck (NTMN) by consideration of new areas, a large sample size and multiple-aspect analysis.
Methods
Our research involved 3125 NTMN cases. We summarized the proportion of various NTMN and the distribution of the neck diseases based on the new international classification. The clinical traits such as sexual proportion and age, etc, were analyzed along with the unknown primary cervical metastatic carcinomas (UPCMC), and built up a mathematical model based on the data above.
Results
There were 68 different diseases identified. Among all the NTMN, the percentage of metastatic carcinomas was 63.3%. The neck masses with a focus above the clavicle comprised 62.3% of the metastatic carcinomas whose focuses were clear. Moreover, other results almost supported the “rule of 80%”. There was an obvious distribution of traits at every sub level. For example, there were 23 different diseases in level III, of which the most common was lymphoma. UPCMC made up 12.3% of all metastatic carcinomas. The clinic cases could be analyzed by our model even to form a primary diagnosis which showed a high coincident rate with clinic diagnosis.
Conclusion
NTMN are complex and various, with a definite distribution in each neck level. Data relating component character, sex ratio and UPCMC et al to the clinical traits of NTMN will provide vigorous support for clinical applications. The mathematical model could be an efficient method to synthetically analyze complicate data of NTMN.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Le Tourneau C, Velten M, Jung GM, et al. Prognostic indicators for survival in head and neck squamous cell carcinomas: analysis of a series of 621 cases. Head Neck, 2005, 27: 801–808.
Som PM, Curtin HD, Mancuso AA. An imaging-based classification for the cervical nodes designed as an adjunct to recent clinically based nodal classifications. Arch Otolaryngol Head Neck Surg, 1999, 125: 388–396.
Bhattacharyya N. Predictive factors for neoplasia and malignancy in a neck mass. Arch Otolaryngol Head Neck Surg, 1999, 125: 303–307.
Robbins KT, Clayman G, Levine PA, et al. Neck dissection classification update. Arch Otolaryngol Head Neck Surg, 2002, 128: 751–758.
Niu YM, Liu XR, Wang DY, et al. Analysis of 1166 cases with non-thyrogenous masses of the neck. Chin J Otorhinolaryngol Skull Base Surg (Chinese), 1999, 5: 150–152.
O’Brien CJ, Traynor SJ, McNeil E, et al. The use of clinical criteria alone in the management of the clinically negative neck among patients with squamous cell carcinoma of the oral cavity and oropharynx. Arch Otolaryngol Head Neck Surg, 2000, 126: 360–365.
Gormly K, Glastonbury CM. Calcified nodal metastasis from squamous cell carcinoma of the head and neck. Australas Radiol, 2004, 48: 240–242.
Lim YC, Choi EC, Lee JS, et al. Is dissection of level IV absolutely necessary in elective lateral neck dissection for clinically N0 laryngeal carcinoma? Oral Oncol, 2006, 42: 101–106.
Spector GJ, Sessions DG, Lenox J, et al. Management of stage IV glottic carcinoma: therapeutic outcomes. Laryngoscope, 2004, 114:1438–1446.
Lim YC, Koo BS, Lee JS, et al. Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. Laryngoscope, 2006, 116: 1148–1152.
Lee SY, Lim YC, Song MH, et al. Level IIb lymph node metastasis in elective neck dissection of oropharyngeal squamous cell carcinoma. Oral Oncol, 2006, 42: 1017–1021.
Yang C, Cohen J, Everts E, et al. Fourth branchial arch sinus: clinical presentation, diagnostic workup, and surgical treatment. Laryngoscope, 1999, 109: 442–446.
Layland MK, Sessions DG, Lenox J. The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+. Laryngoscope, 2005, 115: 629–639.
Mukherji SK, Armao D, Joshi VM. Cervical nodal metastases in squamous cell carcinoma of the head and neck: what to expect. Head Neck, 2001, 23: 995–1005.
Le Chevalier T, Cvitkovic E, Caille P, et al. Early metastatic cancer of unknown primary origin at presentation. A clinical study of 302 consecutive autopsied patients. Arch Intern Med, 1988, 148: 2035–2039.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, Y., Gao, M., Niu, Y. et al. Multi-analysis with mathematic model of 3125 non-thyrogenous masses of the neck. Chin. -Ger. J. Clin. Oncol. 7, 319–325 (2008). https://doi.org/10.1007/s10330-008-0009-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10330-008-0009-z