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The effects of CYP1A1 gene polymorphism and p16 gene methylation on the risk of lung cancer in a Chinese population

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

To investigate the relationship between the genetic polymorphism of CYP1A1 and the genetic susceptibility to lung cancer as well as to study the effects of the methylation in p16 gene on the risk of lung cancer in a Chinese population.

Methods

A case control study was conducted among 47 cases of lung cancer and 94 controls. The genetic polymorphism of CYP1A1 was tested with method of PCR-RFLP, and a methylation-specific PCR (MSP) was performed to detect p16 methylation.

Results

It showed that there was no significant difference in frequencies of the genotypes of CYP1A1 between the two groups (P > 0.05). Synergistic effects were not found between smoking and CYP1A1. Methylated p16 gene was found in 44.7% (21/47) of lung cancer tissues and in 17.0% (8/47) of normal lung tissues with significant difference (P < 0.05).

Conclusion

The genetic polymorphism of CYP1A1 does not increase the risk of lung cancer in a Chinese population. The methylation in p16 gene may be the most common mechanism to inactivate p16 gene in lung cancer, and is not significantly associated with genotype of CYP1A1.

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Authors and Affiliations

  1. Department of Thoracic Surgery, the First Affiliated Hospital, Anhui Medical University, Hefei, 230022, China

    Wenhu Tao, Zaicheng Yu & Xiao Liu

  2. School of Public Health, Anhui Medical University, Hefei, 230022, China

    Yongtang Jin

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  1. Wenhu Tao
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  2. Yongtang Jin
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  3. Zaicheng Yu
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  4. Xiao Liu
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Correspondence to Wenhu Tao.

Additional information

Supported by a grant from the National Natural Sciences Foundation of China (No. 30471427).

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Tao, W., Jin, Y., Yu, Z. et al. The effects of CYP1A1 gene polymorphism and p16 gene methylation on the risk of lung cancer in a Chinese population. Chinese German J Clin Oncol 6, 350–356 (2007). https://doi.org/10.1007/s10330-007-0005-8

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  • DOI: https://doi.org/10.1007/s10330-007-0005-8

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