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Der Einfluss von Oxcarbazepin auf Hormone

The influence of oxcarbacepine on hormones

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Abstract

The literature was analysed with different databases to find relations between oxcarbazepine (OXC) und the hormone system. 46 papers between 1989 and 2005 were screened and investigated. The following facts were found: There is a dose-related influence of OXC on the Cytochrome P450 System of the liver (CYP 3A4) and also an effect on the clearance of ovulation suppressing medication. Also there is a dose-dependent effect of OXC on testosterone and sex hormonebinding globulin. Otherwise we could not find any influence of OXC on secretion of antidiuretic hormone, on the lipid metabolism, on growth and body weight. It is unclear, if there are effects of OXC on thyreoid hormones, sexual mutation and reproductive functions.

Zusammenfassung

Anhand einer Literatur-Recherche wird versucht, einen Überblick zu geben, inwieweit Oxcarbazepin (OXC) in den hormonellen Stoffwechsel eingreift. Dazu wurden 46 Publikationen aus einem Zeitraum zwischen 1989–2005 gesichtet und ausgewertet. Daraus ergeben sich folgende Hinweise: Es gibt einen dosisabhängigen Einfluss von OXC auf das Cytochrom P450-System der Leber (CYP 3A4) und damit auch einen Effekt auf orale Ovulationshemmer. Außerdem findet sich ein dosisabhängiger Effekt auf Testosteron und das Sexualhormon- bindende Globulin. Es gibt keine gesicherten Einflüsse von OXC auf die Sekretion des antidiuretischen Hormons, auf den Lipidstoffwechsel, auf Größen und Gewichts-Wachstum. Nicht eindeutig geklärt sich die Effekte von OXC auf Schilddrüsenhormone, sexuelle Reifung und reproduktive Funktionen.

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  1. Kleinwachau, Sächsisches Epilepsiezentrum Radeberg, Wachauer Straße 30, 01454, Radeberg, Germany

    Thomas Mayer

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Correspondence to Thomas Mayer.

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Mayer, T. Der Einfluss von Oxcarbazepin auf Hormone. Z. Epileptol. 19, 212–219 (2006). https://doi.org/10.1007/s10309-006-0214-0

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  • DOI: https://doi.org/10.1007/s10309-006-0214-0

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