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Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites

  • Original Paper - JMBM
  • Published:
Journal of Industrial Microbiology and Biotechnology

Abstract

Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or 3-carbon branches into their hydrocarbon chains. In recent years, genetic studies have begun to elucidate the mechanisms by which this occurs. In this article we review the incorporation of glycerol-derived precursors into polyketides and propose new mechanisms for the incorporation processes.

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Acknowledgements

Research in the corresponding author’s lab is supported by the UK BBSRC and the European Community.

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  1. Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK

    Laura J. Walton, Christophe Corre & Gregory L. Challis

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  1. Laura J. Walton
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  2. Christophe Corre
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  3. Gregory L. Challis
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Correspondence to Gregory L. Challis.

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Laura J. Walton, Christophe Corre contributed equally to this article

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Walton, L.J., Corre, C. & Challis, G.L. Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites. J IND MICROBIOL BIOTECHNOL 33, 105–120 (2006). https://doi.org/10.1007/s10295-005-0026-7

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