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Antiangiogéniques: les anciens et les nouveaux

Angiogenesis: old and new agents

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Oncologie

Abstract

Angiogenesis constitutes a major process in cancer progression, especially by promoting the growth of malignant cells and dissemination of metastases. The development of anti-angiogenic targeted therapies has made significant progress over the last decade. Since the discovery of bevacizumab, numerous therapies have been designed. Among them, small molecules that inhibit the tyrosine-kinase activity of pro-angiogenic receptors such as VEGFR, are the most studied today. Current research focuses on the development of new targeted-therapies, able to inhibit the activity of several receptors at the same time and with a greater affinity. This article reviews the data on anti-angiogenic targetedtherapies, from available molecules to drugs still in the process of development.

Résumé

L’angiogenèse constitue un processusmajeur de la progression tumorale, en particulier en favorisant la croissance des cellules malignes et leur dissémination sous forme de métastases. Depuis une dizaine d’années, le développement de thérapies ciblées antiangiogéniques connaît un grand engouement. Depuis la découverte du bevacizumab, de nombreuses autres thérapies ont été développées. Parmi elles, les inhibiteurs de l’activité tyrosinekinase des récepteurs proangiogéniques comme le VEGFR sont aujourd’hui les plus étudiés. La recherche actuelle est basée sur le développement de nouvelles thérapies ciblées pouvant inhiber l’activité de plusieurs récepteurs avec une grande affinité. Cette revue reprend les données actuelles sur les thérapies ciblées antiangiogéniques disponibles et en cours de développement.

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  1. Service d’oncologie médicale, hôpital Pitié-Salpétrière, F-75013, Paris, France

    S. Watson & T. de La Motte Rouge

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  1. S. Watson
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Correspondence to T. de La Motte Rouge.

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Watson, S., de La Motte Rouge, T. Antiangiogéniques: les anciens et les nouveaux. Oncologie 14, 216–225 (2012). https://doi.org/10.1007/s10269-012-2142-4

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