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Diagnostic moléculaire des hémopathies lymphoïdes matures

Molecular diagnosis of mature lymphoproliferative disorders

  • Synthèse / Review Article
  • Published:
Oncologie

Abstract

The understanding of the molecular mechanisms associated to lymphoid neoplasia has significantly improved in recent years due to technological advances. Molecular markers have been identified, allowing initial diagnosis. Genomic rearrangements can help to affirm clonality or indicate the disease entity. Some markers are also researched for their prognostic value. Finally, some rearrangements can be used for residual disease assessment during clinical course.

Résumé

La compréhension des mécanismes moléculaires associés aux hémopathies lymphoïdes a considérablement évolué ces dernières années du fait des avancées technologiques. Des marqueurs moléculaires ont été identifiés, permettant de mieux poser le diagnostic initial. Des réarrangements géniques peuvent aider à affirmer une clonalité ou préciser l’entité clinique. Certainsmarqueurs sontégalementrecherchéspour leur valeur pronostique. Enfin, des réarrangements peuvent être utilisés pour évaluer la maladie résiduelle au cours de l’évolution.

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Authors and Affiliations

  1. Service d’hématologie biologique, laboratoire de biologie moléculaire, CHU Pontchaillou, F-35033, Rennes Cedex 9, France

    M. -L. Boulland & T. Fest

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  1. M. -L. Boulland
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  2. T. Fest
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Correspondence to M. -L. Boulland.

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Boulland, M.L., Fest, T. Diagnostic moléculaire des hémopathies lymphoïdes matures. Oncologie 13, 537–541 (2011). https://doi.org/10.1007/s10269-011-2061-5

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  • DOI: https://doi.org/10.1007/s10269-011-2061-5

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