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Gene polymorphisms of interleukin-4, interleukin-10 and transforming growth factor-beta in Graves’ disease

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Abstract

Among genetic factors that may contribute to the development and progression of Graves’ disease (GD) and its complications are polymorphisms in the genes encoding cytokines. The association between GD and the following polymorphisms in anti-inflammatory cytokines was studied in 107 patients with GD and 140 healthy controls: IL-4 (−1098T/G, −590T/C, −33C/T), IL-10 (−1082A/G, −819C/T, −592C/A) and TGF-β (+869T/C, +915G/C). The following alleles and genotypes were significantly (P < 0.01 after correction for multiple testing) more frequent among patients: the IL-4 −1098G allele and GG genotype (OR = 3.12 and 105.00, respectively), IL-4 −33T allele and TT genotype (OR = 2.52 and 118.83, respectively), IL-10 −1082G allele and GG genotype (OR = 2.16 and 6.40, respectively), IL-10 −819T allele, TC and TT genotype (OR = 2.60, 3.68 and 6.76, respectively), IL-10 −592A allele, AC and AA genotype (OR = 2.41, 2.89 and 5.68, respectively), TGF-β +869C allele and CC genotype (OR = 2.24 and 6.21, respectively), and TGF-β +915C allele, CG and CC genotype (OR = 7.81, 11.80 and 20.40, respectively). The only allele and genotype with a lower frequency in patients were IL-4 −590T allele and TC genotype (OR = 0.47 and 0.08, respectively; P < 0.01). In conclusion, this study highlighted the importance of anti-inflammatory cytokine gene polymorphisms in susceptibility to GD.

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Acknowledgments

This study was supported by a grant from Tehran University of Medical Sciences (TUMS), Tehran, Iran

Conflict of interest statement

The authors declare that they have no conflict of interest related to the publication of this article.

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Authors and Affiliations

  1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Omid Khalilzadeh, Mehdi Anvari, Alireza Esteghamati & Armin Rashidi

  2. Molecular Immunology and Immunogenetics Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Omid Khalilzadeh, Mehdi Anvari, Fatemeh Momen-Heravi, Mahdi Mahmoudi, Behrouz Nikbin & Aliakbar Amirzargar

  3. School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

    Fatemeh Momen-Heravi

  4. Immunogenetics Lab, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mahdi Mahmoudi, Behrouz Nikbin & Aliakbar Amirzargar

Authors
  1. Omid Khalilzadeh
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  2. Mehdi Anvari
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Correspondence to Aliakbar Amirzargar.

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Khalilzadeh, O., Anvari, M., Momen-Heravi, F. et al. Gene polymorphisms of interleukin-4, interleukin-10 and transforming growth factor-beta in Graves’ disease. Clin Exp Med 10, 123–128 (2010). https://doi.org/10.1007/s10238-009-0078-5

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  • DOI: https://doi.org/10.1007/s10238-009-0078-5

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