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CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis

  • Original Article
  • Published:
Modern Rheumatology

Abstracts

Objectives

To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients.

Methods

176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism.

Results

No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups.

Conclusions

Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.

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Conflict of interest

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Authors and Affiliations

  1. Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100, Reggio Emilia, Italy

    Giulia Pazzola, Luigi Boiardi, Nicolò Pipitone, Ilaria Padovano, Andrea Caruso, Mariagrazia Catanoso & Carlo Salvarani

  2. Molecular Biology Laboratory, Department of Oncology, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100, Reggio Emilia, Italy

    Bruno Casali, Enrico Farnetti & Davide Nicoli

  3. Servizio di Reumatologia, Azienda Ospedaliera ASMN-IRCCS, Viale Risorgimento 80, 42123, Reggio Emilia, Italy

    Carlo Salvarani

Authors
  1. Giulia Pazzola
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  2. Luigi Boiardi
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  3. Bruno Casali
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  4. Enrico Farnetti
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  5. Davide Nicoli
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  6. Nicolò Pipitone
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  7. Ilaria Padovano
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  8. Andrea Caruso
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  9. Mariagrazia Catanoso
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  10. Carlo Salvarani
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Corresponding author

Correspondence to Carlo Salvarani.

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Pazzola, G., Boiardi, L., Casali, B. et al. CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis. Mod Rheumatol 23, 851–855 (2013). https://doi.org/10.1007/s10165-012-0751-5

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  • DOI: https://doi.org/10.1007/s10165-012-0751-5

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