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Early diagnosis and treatment for remission of clinically amyopathic dermatomyositis complicated by rapid progress interstitial lung disease: a report of two cases

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Modern Rheumatology

Abstract

We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron’s papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including steroid pulse therapy, resulting in significant improvement in respiratory symptoms, clinical data, and imaging. Measurement of anti-CADM-140/MDA5 antibody was useful for obtaining a definitive diagnosis of CADM in these cases.

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References

  1. Sato S, Kuwana M. Clinically amyopathic dermatomyositis. Curr Opin Rheumatol. 2010;22:639–43.

    Article  PubMed  Google Scholar 

  2. Sato S, Hirakata M, Kuwana M, Suwa A, Inada S, Mimori T, et al. Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum. 2005;52:1571–6.

    Article  PubMed  CAS  Google Scholar 

  3. Sato S, Hoshino K, Satoh T, Fujita T, Kawakami Y, Fujita T, et al. RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: association with rapidly progressive interstitial lung disease. Arthritis Rheum. 2009;63:2193–200.

    Article  CAS  Google Scholar 

  4. Sontheimer RD. Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis siné myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness? J Am Acad Dermatol. 2002;46:626–36.

    Article  PubMed  Google Scholar 

  5. Lakhanpal H, Lie JT, Conn DL, Martin WJ 2nd. Pulmonary disease in polymyositis/dermatomyositis: a clinicopathological analysis of 65 autopsy cases. Ann Rheum Dis. 1987;46:23–9.

    Article  PubMed  CAS  Google Scholar 

  6. Koga T, Fujikawa K, Horai Y, Okada A, Kawashiri S, Iwamoto N, et al. The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with dermatomyositis. Rheumatology (Oxford). 2012; in press.

  7. Euwer RL, Sontheimer RD. Amyopathic dermatomyositis: a review. J Invest Dermatol. 1993;100:124S–7S.

    Article  PubMed  CAS  Google Scholar 

  8. Cao H, Parikh TN, Zheng J. Amyopathic dermatomyositis or dermatomyositis-like skin disease: retrospective review of 16 cases with amyopathic dermatomyositis. Clin Rheumatol. 2009;28:979–84.

    Article  PubMed  Google Scholar 

  9. Mukae H, Ishimoto H, Sakamoto N, Hara S, Kakugawa T, Nakayama S, et al. Clinical differences between interstitial lung disease associated with clinically amyopathic dermatomyositis and classic dermatomyositis. Chest. 2009;136:1341–7.

    Article  PubMed  Google Scholar 

  10. Suda T, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Naito T, et al. Interstitial lung diseases associated with amyopathic dermatomyositis. Eur Respir J. 2006;28:1005–12.

    Article  PubMed  CAS  Google Scholar 

  11. Hirakata M. Autoantibodies and their clinical significance in idiopathic inflammatory myopathies; polymyositis/dermatomyositis and related conditions (in Japanese). Nihon Rinsho Meneki Gakkai Kaishi. 2007;30:444–54.

    Article  PubMed  Google Scholar 

  12. Gono T, Kawaguchi Y, Satoh T, Kuwana M, Katsumata Y, Takagi K, et al. Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis. Rheumatology (Oxford). 2010;49:1713–9.

    Article  CAS  Google Scholar 

  13. Sato S. Autoantibodies specifically detected in patients with polymyositis/dermatomyositis. Nihon Rinsho Meneki Gakkai Kaishi. 2006;29:85–93.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Unit of Translational Medicine, Department of Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Yoshiro Horai, Tomohiro Koga, Akitomo Okada, Shin-ya Kawashiri, Mami Tamai, Satoshi Yamasaki, Hideki Nakamura, Tomoki Origuchi & Atsushi Kawakami

  2. The Japanese Red Cross Nagasaki Genbaku Hospital, Morimachi 3-15, Nagasaki, 852-8511, Japan

    Eriko Isomoto

  3. Nagasaki University School of Health Sciences, Nagasaki, Japan

    Tomoki Origuchi

  4. Department of Dermatology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan

    Yasuhito Hamaguchi & Manabu Fujimoto

  5. Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Masataka Kuwana

Authors
  1. Yoshiro Horai
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  2. Eriko Isomoto
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  3. Tomohiro Koga
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  4. Akitomo Okada
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  5. Shin-ya Kawashiri
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  6. Mami Tamai
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  7. Satoshi Yamasaki
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  8. Hideki Nakamura
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  9. Tomoki Origuchi
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  10. Yasuhito Hamaguchi
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  11. Manabu Fujimoto
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  12. Masataka Kuwana
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  13. Atsushi Kawakami
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Corresponding author

Correspondence to Yoshiro Horai.

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Horai, Y., Isomoto, E., Koga, T. et al. Early diagnosis and treatment for remission of clinically amyopathic dermatomyositis complicated by rapid progress interstitial lung disease: a report of two cases. Mod Rheumatol 23, 190–194 (2013). https://doi.org/10.1007/s10165-012-0637-6

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  • DOI: https://doi.org/10.1007/s10165-012-0637-6

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