Skip to main content

Advertisement

SpringerLink
Log in

Wegener’s granulomatosis detected initially by integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography

  • Case Report
  • Published:
Modern Rheumatology

Abstract

Early diagnosis is crucial for effective treatment of Wegener’s granulomatosis, although this disease shows only atypical symptoms in the primary stage. This report describes a patient suspected of having a malignancy based on integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT), which showed increased uptake in pulmonary nodules and nasopharyngeal mucosa. Integrated PET/CT is therefore considered to be useful to confirm the distribution and determine the optimal site for biopsy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Hoffman GS, Kerr GS, Leavitt RY, Hallahan CW, Lebovics RS, Travis WD, et al. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. 1992;116:488–98.

    CAS  PubMed  Google Scholar 

  2. Slot MC, Tervaert JW, Franssen CF, Stegeman CA. Renal survival and prognostic factors in patients with PR3-ANCA associated vasculitis with renal involvement. Kidney Int. 2003;63:670–7.

    Article  PubMed  Google Scholar 

  3. Belhocine T, Blockmans D, Hustinx R, Vandevivere J, Mortelmans L. Imaging of large vessel vasculitis with (18)FDG PET: illusion or reality? A critical review of the literature data. Eur J Nucl Med Mol Imaging. 2003;30:1305–13.

    Article  PubMed  Google Scholar 

  4. Blockmans D. The use of (18F)fluoro-deoxyglucose positron emission tomography in the assessment of large vessel vasculitis. Clin Exp Rheumatol. 2003;21:S15–22.

    CAS  PubMed  Google Scholar 

  5. Erasmus JJ, McAdams HP, Patz EF Jr, Goodman PC, Coleman RE. Thoracic FDG PET: state of the art. Radiographics. 1998;18:5–20.

    CAS  PubMed  Google Scholar 

  6. Roberts PF, Follette DM, von Haag D, Park JA, Valk PE, Pounds TR, et al. Factors associated with false-positive staging of lung cancer by positron emission tomography. Ann Thorac Surg. 2000;70:1154–9.

    Article  CAS  PubMed  Google Scholar 

  7. Webb M, Chambers A, AL-Nahhas A, Mason JC, Maudlin L, Rahman L, et al. The role of 18F-FDG PET in characterising disease activity in Takayasu arteritis. Eur J Nucl Med Mol Imaging. 2004;31:627–34.

    Article  PubMed  Google Scholar 

  8. Blockmans D, Baeyens H, Van Loon R, Lauwers G, Bobbaers H. Periaortitis and aortic dissection due to Wegener’s granulomatosis. Clin Rheumatol. 2000;19:161–4.

    Article  CAS  PubMed  Google Scholar 

  9. Beggs AD, Hain SF. F-18 FDG-positron emission tomographic scanning and Wegener’s granulomatosis. Clin Nucl Med. 2002;27:705–6.

    Article  PubMed  Google Scholar 

  10. Maruoka H, Koga T, Takeo M, Honda S, Yuge K, Fukuda T, et al. Increased splenic fluorodeoxyglucose uptake in a patient with granulomatous angitis. Intern Med. 2007;46:909–11.

    Article  PubMed  Google Scholar 

  11. Armani M, Spinazzi M, Andrigo C, Fassina A, Mantovan M, Tavolato B. Severe dysphagia in lower cranial nerve involvement as the initial symptom of Wegener’s granulomatosis. J Neurol Sci. 2007;263:187–90.

    Article  PubMed  Google Scholar 

  12. Vandergheynst F, Goldman S, Cogan E. Wegener’s granulomatosis overlapping with Takayasu’s arteritis revealed by FDG-PET scan. Eur J Intern Med. 2007;18:148–9.

    Article  CAS  PubMed  Google Scholar 

  13. Cordier JF, Valeyre D, Guillevin L, Loire R, Brechot JM. Pulmonary Wegener’s granulomatosis. A clinical and imaging study of 77 cases. Chest. 1990;97:906–12.

    Article  CAS  PubMed  Google Scholar 

  14. Coleman RE, Delbeke D, Guiberteau MJ, Conti PS, Royal HD, Weinreb JC, et al. Concurrent PET/CT with an integrated imaging system: intersociety dialogue from the joint working group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance. J Nucl Med. 2005;46:1225–39.

    PubMed  Google Scholar 

  15. Schöder H, Yeung HW, Gonen M, Kraus D, Larson SM. Head and neck cancer: clinical usefulness and accuracy of PET/CT image fusion. Radiology. 2004;231:65–72.

    Article  PubMed  Google Scholar 

  16. Takala JH, Kautiainen H, Malmberg H, Leirisalo-Repo M. Wegener’s granulomatosis in Finland in 1981–2000: clinical presentation and diagnostic delay. Scand J Rheumatol. 2008;37:435–8.

    Article  CAS  PubMed  Google Scholar 

  17. Leavitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP, et al. The American College of Rheumatology 1990 criteria for the classification of Wegener’s granulomatosis. Arthr Rheum. 1990;33:1101–7.

    CAS  Google Scholar 

  18. Schnabel A, Holl-Ulrich K, Dalhoff K, Reuter M, Gross WL. Efficacy of transbronchial biopsy in pulmonary vaculitides. Eur Respir J. 1997;10:2738–43.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest statement

None.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, 5-30 Kitatakamatsu-cho, Miyazaki, 880-8510, Japan

    Naoyasu Ueda, Daisuke Himeji & Akira Ueda

  2. Department of Pathology, Miyazaki Prefectural Miyazaki Hospital, 5-30 Kitatakamatsu-cho, Miyazaki, 880-8510, Japan

    Yoshiya Shimao

  3. Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Yasushi Inoue, Kensuke Oryoji, Hiroki Mitoma, Yojiro Arinobu, Hiroaki Niiro, Hiroshi Tsukamoto, Takahiko Horiuchi & Koichi Akashi

Authors
  1. Naoyasu Ueda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasushi Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daisuke Himeji
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiya Shimao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kensuke Oryoji
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hiroki Mitoma
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yojiro Arinobu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hiroaki Niiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hiroshi Tsukamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Takahiko Horiuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Akira Ueda
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Koichi Akashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yasushi Inoue.

About this article

Cite this article

Ueda, N., Inoue, Y., Himeji, D. et al. Wegener’s granulomatosis detected initially by integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Mod Rheumatol 20, 205–209 (2010). https://doi.org/10.1007/s10165-009-0255-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10165-009-0255-0

Keywords

Search

Navigation