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FDG PET/CT in TB: Mimics, Pitfalls, and Limitations

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PET/CT in Tuberculosis

Part of the book series: Clinicians’ Guides to Radionuclide Hybrid Imaging ((PET/CT))

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Abstract

One of the main drawbacks of fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is its lack of specificity in order to distinguish between different inflammations and/or malignancies, which comes as particularly important when evaluating tuberculosis, a disease known as a great mimicker, which can masquerade as various number of inflammatory or malignant disorders. Patients with cancer are more prone to develop active tuberculosis and vice versa, TB patients are at greater risk of lung cancer compared to normal population. Dual-phase FDG PET imaging has been tried for the differentiation of inflammation from malignancy with some promising results, but there are some controversies when it comes to patients with tuberculosis. On the other hand, there are some inflammatory diseases, such as sarcoidosis, and also infections with other Mycobacterium species which could be mistaken for TB on FDG PET/CT. Some difficulties in evaluation of disease activity and therapy response on FDG PET/CT have also been reported even in individuals with confirmed diagnosis of TB. Altogether, tuberculosis on FDG PET/CT can have a myriad of manifestation that sometimes can be perplexing to interpret even for experienced reader.

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Authors and Affiliations

  1. Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Dragana Sobic Saranovic

  2. Center for Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia

    Dragana Sobic Saranovic & Milica Stojiljkovic

Authors
  1. Dragana Sobic Saranovic
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  2. Milica Stojiljkovic
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Editors and Affiliations

  1. Center for Nuclear Medicine, Clinical Center of Serbia, Faculty of Medicine University of Belgrade, Belgrade, Serbia

    Dragana Sobic Saranovic

  2. Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa

    Mariza Vorster

  3. Deptartment of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Lucknow, Lucknow, India

    Sanjay Gambhir

  4. Nuclear Medicine and Diagnostic Imaging, International Atomic Energy Agency, Wien-Vereinte Nationen, Wien, Austria

    Thomas Neil Pascual

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Sobic Saranovic, D., Stojiljkovic, M. (2020). FDG PET/CT in TB: Mimics, Pitfalls, and Limitations. In: Sobic Saranovic, D., Vorster, M., Gambhir, S., Pascual, T. (eds) PET/CT in Tuberculosis. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-030-47009-8_10

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  • DOI: https://doi.org/10.1007/978-3-030-47009-8_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-47008-1

  • Online ISBN: 978-3-030-47009-8

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