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Fractalkine in rheumatoid arthritis and allied conditions

  • REVIEW ARTICLE
  • Published:
Modern Rheumatology

Abstract

Leukocyte adhesion and trafficking at the endothelium requires both adhesion molecules and chemotactic factors. Fractalkine (CX3C) is a unique chemokine, and is expressed on tumor necrosis factor-α- and interleukin-1-activated endothelial cells (ECs). Fractalkine receptor, CX3CR1, is expressed on NK cells, monocytes, and some portion of CD4- and CD8-positive T cells. Interactions between fractalkine and CX3CR1 can mediate not only chemotaxis, but also cell adhesion in the absence of substrates for other adhesion molecules. Furthermore, fractalkine activates NK cells, leading to increased cytotoxicity and interferon-γ production. Recently, accumulating evidence has shown that fractalkine is involved in the pathogenesis of rheumatoid arthritis and allied conditions. This review examines new concepts underlying fractalkine-mediated leukocyte migration and tissue damage, focusing primarily on the pathophysiological roles of fractalkine in rheumatic diseases.

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References

  1. FW Luscinskas MA Gimbrone (1996) ArticleTitleEndothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment Annu Rev Med 47 413–21 10.1146/annurev.med.47.1.413 Occurrence Handle10.1146/annurev.med.47.1.413 Occurrence Handle1:CAS:528:DyaK28XitlSntLk%3D Occurrence Handle8712792

    Article  CAS  PubMed  Google Scholar 

  2. DB Cines ES Pollak CA Buck J Loscalzo GA Zimmerman RP McEver et al. (1998) ArticleTitleEndothelial cells in physiology and in the pathophysiology of vascular disorders Blood 91 3527–61 Occurrence Handle1:CAS:528:DyaK1cXjtFersr8%3D Occurrence Handle9572988

    CAS  PubMed  Google Scholar 

  3. A Montovani F Bussolino M Introna (1997) ArticleTitleCytokine regulation of endothelial cell function: from molecular level to the bedside Immunol Today 18 231–40 10.1016/S0167-5699(97)81662-3 Occurrence Handle10.1016/S0167-5699(97)81662-3

    Article  Google Scholar 

  4. DD Taub JJ Oppenheim (1994) ArticleTitleChemokines, inflammation and the immune system Ther Immunol 1 229–46 Occurrence Handle1:CAS:528:DyaK2cXmslyht78%3D Occurrence Handle7584498

    CAS  PubMed  Google Scholar 

  5. BJ Rollins (1997) ArticleTitleChemokines Blood 90 909–28 Occurrence Handle1:CAS:528:DyaK2sXkvVWiu7k%3D Occurrence Handle9242519

    CAS  PubMed  Google Scholar 

  6. M Baggiolini B Dewald B Moser (1994) ArticleTitleInterleukin-8 and related chemokines-CXC and CC chemokines Adv Immunol 55 97–179 Occurrence Handle10.1016/S0065-2776(08)60509-X Occurrence Handle1:CAS:528:DyaK2cXktlamtr8%3D Occurrence Handle8304236

    Article  CAS  PubMed  Google Scholar 

  7. PM Murphy (1994) ArticleTitleThe molecular biology of leukocyte chemoattractant receptors Annu Rev Immunol 12 593–633 10.1146/annurev.iy.12.040194.003113 Occurrence Handle10.1146/annurev.iy.12.040194.003113 Occurrence Handle1:CAS:528:DyaK2MXnvFyl Occurrence Handle8011292

    Article  CAS  PubMed  Google Scholar 

  8. C Gerard BJ Rollins (2001) ArticleTitleChemokine and disease Nat Immunol 2 108–15 10.1038/84209 Occurrence Handle10.1038/84209 Occurrence Handle1:CAS:528:DC%2BD3MXhtVOlsL4%3D Occurrence Handle11175802

    Article  CAS  PubMed  Google Scholar 

  9. AEI Proudfoot (2002) ArticleTitleChemokine receptors: Multifaceted therapeutic targets Nat Rev Immunol 2 106–15 10.1038/nri722 Occurrence Handle10.1038/nri722 Occurrence Handle1:CAS:528:DC%2BD38XitFSnu7o%3D Occurrence Handle11910892

    Article  CAS  PubMed  Google Scholar 

  10. JF Bazan KB Bacon G Hardiman W Wang K Soo D Ross et al. (1997) ArticleTitleA new class of membrane-bound chemokine with a CX3C motif Nature 385 640–4 10.1038/385640a0 Occurrence Handle10.1038/385640a0 Occurrence Handle1:CAS:528:DyaK2sXht1yks7w%3D Occurrence Handle9024663

    Article  CAS  PubMed  Google Scholar 

  11. T Imai K Hieshima C Haskell M Baba M Nagira M Nishimura et al. (1997) ArticleTitleIdentification and molecular characterization of Fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion Cell 91 521–30 10.1016/S0092-8674(00)80438-9 Occurrence Handle10.1016/S0092-8674(00)80438-9 Occurrence Handle1:CAS:528:DyaK2sXnsFGltL0%3D Occurrence Handle9390561

    Article  CAS  PubMed  Google Scholar 

  12. S Goda T Imai O Yoshie O Yoneda H Inoue Y Nagano et al. (2000) ArticleTitleCX3C-chemokine, fractalkine enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and independent mechanisms J Immunol 164 4313–20 Occurrence Handle1:CAS:528:DC%2BD3cXis1WksLg%3D Occurrence Handle10754331

    CAS  PubMed  Google Scholar 

  13. H Umehara ET Bloom T Okazaki N Domae T Imai (2001) ArticleTitleFractalkine and vascular injury Trends Immunol 22 602–7 10.1016/S1471-4906(01)02051-8 Occurrence Handle10.1016/S1471-4906(01)02051-8 Occurrence Handle1:CAS:528:DC%2BD3MXot1Sitb8%3D Occurrence Handle11698220

    Article  CAS  PubMed  Google Scholar 

  14. H Umehara ET Bloom T Okazaki O Yoshie T Imai (2004) ArticleTitleFractalkine and vascular biology: from basic research to clinical diseases (Review) Arterioscler Thromb Vasc Biol 24 34–40 10.1161/01.ATV.0000095360.62479.1F Occurrence Handle10.1161/01.ATV.0000095360.62479.1F Occurrence Handle1:CAS:528:DC%2BD3sXhtVWhurvP Occurrence Handle12969992

    Article  CAS  PubMed  Google Scholar 

  15. Y Pan C Lioyd H Zhou S Dolich J Deeds J-A Gonzalo et al. (1997) ArticleTitleNeurotactin, a membrane-anchored chemokine upregulated in brain inflammation Nature 387 611–7 10.1038/42491 Occurrence Handle10.1038/42491 Occurrence Handle1:CAS:528:DyaK2sXktFCitLc%3D Occurrence Handle9177350

    Article  CAS  PubMed  Google Scholar 

  16. AM Fong HP Erickson JP Zachariah S Poon NJ Schamberg T Imai et al. (2000) ArticleTitleUltrastructure and function of the fractalkine mucin domain in CX3C chemokine domain presentation J Biol Chem 275 3781–6 10.1074/jbc.275.6.3781 Occurrence Handle10.1074/jbc.275.6.3781 Occurrence Handle1:CAS:528:DC%2BD3cXht12hu7g%3D Occurrence Handle10660527

    Article  CAS  PubMed  Google Scholar 

  17. CA Haskell MD Cleary IF Charo (2000) ArticleTitleUnique role of the chemokine domain of fractalkine in cell capture J Biol Chem 275 34183–9 10.1074/jbc.M005731200 Occurrence Handle10.1074/jbc.M005731200 Occurrence Handle1:CAS:528:DC%2BD3cXotFWlsrw%3D Occurrence Handle10940307

    Article  CAS  PubMed  Google Scholar 

  18. H Umehara S Goda T Imai Y Nagano Y Minami Y Tanaka et al. (2001) ArticleTitleFractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1 Immunol Cell Biol 79 298–302 10.1046/j.1440-1711.2001.01004.x Occurrence Handle10.1046/j.1440-1711.2001.01004.x Occurrence Handle1:CAS:528:DC%2BD3MXltVGhtbo%3D Occurrence Handle11380684

    Article  CAS  PubMed  Google Scholar 

  19. P Kourilsky P Truffa-Bachi (2001) ArticleTitleCytokine fields and the polarization of the immune response Trends Immunol 22 502–9 10.1016/S1471-4906(01)02012-9 Occurrence Handle10.1016/S1471-4906(01)02012-9 Occurrence Handle1:CAS:528:DC%2BD3MXmt1ynsLc%3D Occurrence Handle11525941

    Article  CAS  PubMed  Google Scholar 

  20. SG Rhodes SP Graham (2002) ArticleTitleIs ‘timing’ important for cytokine polarization? Trends Immunol 23 246–9 10.1016/S1471-4906(02)02200-7 Occurrence Handle10.1016/S1471-4906(02)02200-7 Occurrence Handle1:CAS:528:DC%2BD38Xjtl2ltL4%3D Occurrence Handle12102745

    Article  CAS  PubMed  Google Scholar 

  21. O Yoshie T Imai H Nomiyama (2001) ArticleTitleRelated article chemokines in immunity Adv Immunol 78 57–110 Occurrence Handle10.1016/S0065-2776(01)78002-9 Occurrence Handle1:CAS:528:DC%2BD3MXlsV2kt7c%3D Occurrence Handle11432208

    Article  CAS  PubMed  Google Scholar 

  22. F Sallusto CR Mackay A Lanzavecchia (2000) ArticleTitleThe role of chemokine receptors in primary, effector, and memory immune responses Annu Rev Immunol 18 593–620 10.1146/annurev.immunol.18.1.593 Occurrence Handle10.1146/annurev.immunol.18.1.593 Occurrence Handle1:CAS:528:DC%2BD3cXjs1Gmtr0%3D Occurrence Handle10837070

    Article  CAS  PubMed  Google Scholar 

  23. S Shresta CT Pham DA Thomas TA Grauber TJ Ley (1998) ArticleTitleHow do cytotoxic lymphocytes kill their targets? Curr Opin Immunol 10 581–7 10.1016/S0952-7915(98)80227-6 Occurrence Handle10.1016/S0952-7915(98)80227-6 Occurrence Handle1:CAS:528:DyaK1cXmvVOls7g%3D Occurrence Handle9794837

    Article  CAS  PubMed  Google Scholar 

  24. D Hamann MTL Roos RAW van Lier (1999) ArticleTitleFace and phases of human CD8+ T-cell development Immunol Today 20 177–80 10.1016/S0167-5699(99)01444-9 Occurrence Handle10.1016/S0167-5699(99)01444-9 Occurrence Handle1:CAS:528:DyaK1MXitlGnsLY%3D Occurrence Handle10203715

    Article  CAS  PubMed  Google Scholar 

  25. H Tomiyama T Matsuda M Takiguchi (2002) ArticleTitleDifferentiation of human CD8+ T cells from a memory to memory/effector phenotype J Immunol 168 5538–50 Occurrence Handle1:CAS:528:DC%2BD38XktFCrsLw%3D Occurrence Handle12023349

    CAS  PubMed  Google Scholar 

  26. M Nishimura H Umehara T Nakayama O Yoneda K Hieshima M Kakizaki et al. (2002) ArticleTitleDual functions of fractalkine/CX3CR1 in trafficking of circulating cytotoxic effector lymphocytes that are defined by CX3CR1 expression J Immunol 168 6173–80 Occurrence Handle1:CAS:528:DC%2BD38XksFWmt7Y%3D Occurrence Handle12055230

    CAS  PubMed  Google Scholar 

  27. Y Tanaka DH Adams S Hubscher H Hirano U Siebenlist S Shaw (1993) ArticleTitleT-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β Nature 361 79–82 10.1038/361079a0 Occurrence Handle10.1038/361079a0 Occurrence Handle1:CAS:528:DyaK3sXnvFSruw%3D%3D Occurrence Handle7678446

    Article  CAS  PubMed  Google Scholar 

  28. AM Fong LA Robinson DA Steeber TF Tedder O Yoshie T Imai et al. (1998) ArticleTitleFractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow J Exp Med 188 1413–9 10.1084/jem.188.8.1413 Occurrence Handle10.1084/jem.188.8.1413 Occurrence Handle1:CAS:528:DyaK1cXmslKltb8%3D Occurrence Handle9782118

    Article  CAS  PubMed  Google Scholar 

  29. CA Haskell MD Cleary IF Charo (1999) ArticleTitleMolecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation J Biol Chem 274 10053–8 10.1074/jbc.274.15.10053 Occurrence Handle10.1074/jbc.274.15.10053 Occurrence Handle1:CAS:528:DyaK1MXis1Gjtrw%3D Occurrence Handle10187784

    Article  CAS  PubMed  Google Scholar 

  30. L Moretta E Ciccone MC Mingari R Biassoni A Moretta (1993) ArticleTitleHuman natural killer cells: Origin, clonality, specificity, and receptors Adv Immunol 55 341–80 10.1016/S0065-2776(08)60513-1 Occurrence Handle10.1016/S0065-2776(08)60513-1

    Article  Google Scholar 

  31. H Umehara J-Y Huang T Kono FH Tabassam T Okazaki ET Bloom et al. (1997) ArticleTitleInvolvement of protein tyrosine kinase p72syk and phosphatidylinositol 3-kinase in CD2-mediated granular exocytosis in natural killer cell line J Immunol 159 1200–7 Occurrence Handle1:CAS:528:DyaK2sXkslKgtrY%3D Occurrence Handle9233614

    CAS  PubMed  Google Scholar 

  32. LL Lanier (2001) ArticleTitleOn guard-activating NK cell receptors Nat Immunol 2 23–7 10.1038/83130 Occurrence Handle10.1038/83130 Occurrence Handle1:CAS:528:DC%2BD3MXjslymtw%3D%3D Occurrence Handle11135574

    Article  CAS  PubMed  Google Scholar 

  33. O Yoneda T Imai S Gouda H Inoue A Yamauchi T Okazaki et al. (2000) ArticleTitleNK cell-mediated vascular injury J Immunol 164 4055–62 Occurrence Handle1:CAS:528:DC%2BD3cXis1Wlu7w%3D Occurrence Handle10754298

    CAS  PubMed  Google Scholar 

  34. WE Seaman (2000) ArticleTitleNatural killer cells and natural killer T cells Arthritis Rheum 43 1204–17 10.1002/1529-0131(200006)43:6<1204::AID-ANR3>3.0.CO;2-I Occurrence Handle10.1002/1529-0131(200006)43:6<1204::AID-ANR3>3.0.CO;2-I Occurrence Handle1:CAS:528:DC%2BD3cXkvFWnurw%3D Occurrence Handle10857779

    Article  CAS  PubMed  Google Scholar 

  35. J Rengarajan SJ Szabo LH Glimcher (2000) ArticleTitleTranscriptional regulation of Th1/Th2 polarization Immunol Today 21 479–83 10.1016/S0167-5699(00)01712-6 Occurrence Handle10.1016/S0167-5699(00)01712-6 Occurrence Handle1:CAS:528:DC%2BD3cXmvFyltrs%3D Occurrence Handle11071525

    Article  CAS  PubMed  Google Scholar 

  36. KM Murphy SL Reiner (2002) ArticleTitleThe lineage decisions of helper T cells Nat Rev Immunol 2 933–44 10.1038/nri954 Occurrence Handle10.1038/nri954 Occurrence Handle1:CAS:528:DC%2BD38XptFKnu7g%3D Occurrence Handle12461566

    Article  CAS  PubMed  Google Scholar 

  37. O Yoneda T Imai H Inoue M Nishimura Y Minami ET Bloom et al. (2003) ArticleTitleMembrane bound form of fractalkine induces IFN-γ production by NK cells: a role for Th1 response Eur J Immunol 33 53–8 10.1002/immu.200390007 Occurrence Handle10.1002/immu.200390007 Occurrence Handle1:CAS:528:DC%2BD3sXos1Snug%3D%3D Occurrence Handle12594832

    Article  CAS  PubMed  Google Scholar 

  38. JH Ruth JB Rottman KJ Katschke SuffixJr S Qin L Wu G LaRosa et al. (2001) ArticleTitleSelective lymphocytes chemokine receptor expression in the rheumatoid joint Arthritis Rheum 44 2750–60 10.1002/1529-0131(200112)44:12<2750::AID-ART462>3.0.CO;2-C Occurrence Handle10.1002/1529-0131(200112)44:12<2750::AID-ART462>3.0.CO;2-C Occurrence Handle1:CAS:528:DC%2BD38XislCmtQ%3D%3D Occurrence Handle11762935

    Article  CAS  PubMed  Google Scholar 

  39. JH Ruth MV Volin GK Haines SuffixIII DC Woodruff KJ Katschke SuffixJr JM Woods et al. (2001) ArticleTitleFractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis Arthritis Rheum 44 1568–81 10.1002/1529-0131(200107)44:7<1568::AID-ART280>3.0.CO;2-1 Occurrence Handle10.1002/1529-0131(200107)44:7<1568::AID-ART280>3.0.CO;2-1 Occurrence Handle1:CAS:528:DC%2BD38Xkt1ar Occurrence Handle11465708

    Article  CAS  PubMed  Google Scholar 

  40. T Nanki T Imai K Nagasaka Y Urasaki Y Nonomura K Taniguchi et al. (2002) ArticleTitleMigration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into synovium of patients with rheumatoid arthritis Arthritis Rheum 46 2878–83 10.1002/art.10622 Occurrence Handle10.1002/art.10622 Occurrence Handle1:CAS:528:DC%2BD38XptlSksrw%3D Occurrence Handle12428227

    Article  CAS  PubMed  Google Scholar 

  41. H Sawai YW Park J Roberson T Imai JJ Goronzy CM Weyand (2005) ArticleTitleT cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis Arthritis Rheum 52 1392–401 10.1002/art.21140 Occurrence Handle10.1002/art.21140 Occurrence Handle1:CAS:528:DC%2BD2MXkvFCju7o%3D Occurrence Handle15880821

    Article  CAS  PubMed  Google Scholar 

  42. MV Volin JM Woods MA Amin MA Connors LA Harlow AE Koch (2001) ArticleTitleFractalkine: a novel angiogenic chemokine in rheumatoid arthritis Am J Pathol 159 1521–30 Occurrence Handle1:CAS:528:DC%2BD3MXnvVCmsL0%3D Occurrence Handle11583978

    CAS  PubMed  Google Scholar 

  43. T Nanki Y Urasaki T Imai M Nishimura K Muramoto T Kubota et al. (2004) ArticleTitleInhibition of fractalkine ameliorates murine collagen-induced arthritis J Immunol 173 7010–6 Occurrence Handle1:CAS:528:DC%2BD2cXhtVShsbrP Occurrence Handle15557198

    CAS  PubMed  Google Scholar 

  44. N Yajima T Kasama T Isozaki T Odai M Matsunawa M Negishi et al. (2005) ArticleTitleElevated levels of soluble fractalkine in active systemic lupus erythematosus Arthritis Rheum 52 1670–5 10.1002/art.21042 Occurrence Handle10.1002/art.21042 Occurrence Handle1:CAS:528:DC%2BD2MXlvFChtbo%3D Occurrence Handle15934075

    Article  CAS  PubMed  Google Scholar 

  45. S Chen KB Bacon L Li GE Garcia Y Xia D Lo et al. (1998) ArticleTitleIn vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II J Exp Med 188 193–8 10.1084/jem.188.1.193 Occurrence Handle10.1084/jem.188.1.193 Occurrence Handle1:CAS:528:DyaK1cXksFOhu7k%3D Occurrence Handle9653095

    Article  CAS  PubMed  Google Scholar 

  46. L Feng S Chen GE Garcia Y Xia MA Siani P Botti et al. (1999) ArticleTitlePrevention of crescent glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 Kidney Int 56 612–20 10.1046/j.1523-1755.1999.00604.x Occurrence Handle10.1046/j.1523-1755.1999.00604.x Occurrence Handle1:CAS:528:DyaK1MXltlOgsrk%3D Occurrence Handle10432400

    Article  CAS  PubMed  Google Scholar 

  47. A Inoue H Hasegawa M Kohno MR Ito M Terada T Imai et al. (2005) ArticleTitleAntagonist of fractalkine (CX3CL1) delays the inhibition and ameliorates the progression of lupus nephritis in MRL/lpr mice Arthritis Rheum 52 1522–33 10.1002/art.21007 Occurrence Handle10.1002/art.21007 Occurrence Handle1:CAS:528:DC%2BD2MXkvFCisro%3D Occurrence Handle15880599

    Article  CAS  PubMed  Google Scholar 

  48. M Hasegawa S Sato T Echigo M Ysui K Takehara (2005) ArticleTitleUp regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosis Ann Rheum Dis 64 21–8 10.1136/ard.2003.018705 Occurrence Handle10.1136/ard.2003.018705 Occurrence Handle1:CAS:528:DC%2BD2MXptVaktg%3D%3D Occurrence Handle15608300

    Article  CAS  PubMed  Google Scholar 

  49. F Suzuki T Nanki T Imai H Kikuchi S Hirohata H Kohsaka et al. (2005) ArticleTitleInhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice J Immunol 175 6987–96 Occurrence Handle1:CAS:528:DC%2BD2MXhtF2ju7fP Occurrence Handle16272359

    CAS  PubMed  Google Scholar 

  50. K Balabanian A Foussat P Dormuller I Durand-Gasselin F Capel L Bouchet-Delbos et al. (2002) ArticleTitleCX3C chemokine fractalkine in pulmonary arterial hypertension Am J Respir Crit Care Med 165 1419–25 10.1164/rccm.2106007 Occurrence Handle10.1164/rccm.2106007 Occurrence Handle12016106

    Article  PubMed  Google Scholar 

  51. P Dorfmuller F Perros K Balabanian M Humbert (2003) ArticleTitleInflammation in pulmonary arterial hypertension Eur Respir J 22 358–63 10.1183/09031936.03.00038903 Occurrence Handle10.1183/09031936.03.00038903 Occurrence Handle1:STN:280:DC%2BD3svht1yntw%3D%3D Occurrence Handle12952274

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical University, Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan

    Hisanori Umehara, Masao Tanaka, Toshioki Sawaki, Zhe-Xiong Jin, Cheng-Ri Huang, Lingli Dong, Takafumi Kawanami, Hiromi Karasawa, Yasufumi Masaki, Toshihiro Fukushima & Yuko Hirose

  2. Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Masao Tanaka

  3. Department of Clinical Laboratory, Medicine/Hematology, Faculty of Medicine, Tottori University, Tottori, Japan

    Toshirou Okazaki

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  1. Hisanori Umehara
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  2. Masao Tanaka
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Correspondence to Hisanori Umehara.

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Umehara, H., Tanaka, M., Sawaki, T. et al. Fractalkine in rheumatoid arthritis and allied conditions. Mod Rheumatol 16, 124–130 (2006). https://doi.org/10.1007/s10165-006-0471-9

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