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Stimulus Frequency Otoacoustic Emission Delays and Generating Mechanisms in Guinea Pigs, Chinchillas, and Simulations

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Abstract

According to coherent reflection theory (CRT), stimulus frequency otoacoustic emissions (SFOAEs) arise from cochlear irregularities coherently reflecting energy from basilar membrane motion within the traveling-wave peak. This reflected energy arrives in the ear canal predominantly with a single delay at each frequency. However, data from humans and animals indicate that (1) SFOAEs can have multiple delay components, (2) low-frequency SFOAE delays are too short to be accounted for by CRT, and (3) “SFOAEs” obtained with a 2nd (“suppressor”) tone ≥2 octaves above the probe tone have been interpreted as arising from the area basal to the region of cochlear amplification. To explore these issues, we collected SFOAEs by the suppression method in guinea pigs and time-frequency analyzed these data, simulated SFOAEs, and published chinchilla SFOAEs. Time-frequency analysis revealed that most frequencies showed only one SFOAE delay component while other frequencies had multiple components including some with short delays. We found no systematic patterns in the occurrence of multiple delay components. Using a cochlear model that had significant basilar membrane motion only in the peak region of the traveling wave, simulated SFOAEs had single and multiple delay components similar to the animal SFOAEs. This result indicates that multiple components (including ones with short delays) can originate from cochlear mechanical irregularities in the SFOAE peak region and are not necessarily indicative of SFOAE sources in regions ≥2 octaves basal of the SFOAE peak region. We conclude that SFOAEs obtained with suppressors close to the probe frequency provide information primarily about the mechanical response in the region that receives amplification, and we attribute the too-short SFOAE delays at low frequencies to distortion-source SFOAEs and coherent reflection from multiple cochlear motions. Our findings suggest that CRT needs revision to include reflections from multiple motions in the cochlear apex.

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Acknowledgments

We thank Drs. C.A. Shera, M.C. Brown, D.C. Mountain, and K. K. Charaziak for comments on earlier versions of the manuscript. This work was supported by RO1 DC000235, R01 DC003687, T32 DC00038, P30 DC005209, and a NSF GRFP, and was part M. B-G’s PhD thesis.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Eaton-Peabody Lab, Mass. Eye and Ear Infirmary, 243 Charles St, Boston, MA, 02114, USA

    Maria A. Berezina-Greene & John J. Guinan Jr.

  2. Harvard-MIT HST Speech and Hearing Bioscience and Technology Program, Cambridge, MA, USA

    Maria A. Berezina-Greene & John J. Guinan Jr.

  3. Harvard Medical School, Boston, MA, USA

    John J. Guinan Jr.

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  1. Maria A. Berezina-Greene
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  2. John J. Guinan Jr.
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Correspondence to Maria A. Berezina-Greene.

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Berezina-Greene, M.A., Guinan, J.J. Stimulus Frequency Otoacoustic Emission Delays and Generating Mechanisms in Guinea Pigs, Chinchillas, and Simulations. JARO 16, 679–694 (2015). https://doi.org/10.1007/s10162-015-0543-7

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  • DOI: https://doi.org/10.1007/s10162-015-0543-7

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