Abstract
Renal allograft recipients are prone to opportunistic infections, rarely multiple coexisting infections, due to the immunocompromised state. To the best of our knowledge, no case of a co-existing polyoma virus nephropathy and pulmonary histoplasmosis in a renal allograft recipient has been reported so far in the available literature. A 55-year-old male renal allograft recipient underwent graft biopsy for asymptomatic graft dysfunction. The graft biopsy showed features of polyoma virus nephropathy. Soon after, he developed fever with pulmonary nodules. Fine-needle aspiration from lung nodules showed intracellular yeast forms of histoplasma. The patient responded well to amphotericin B with subsidence of fever. The co-existence of renal allograft-limited infection like polyoma virus and systemic fungal infection such as histoplasmosis should be kept in mind in a transplant recipient with graft dysfunction and non-specific systemic symptoms. Prompt recognition of these infections permits the clinician to institute appropriate therapeutic modification and improved survival.
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References
Liptak P, Kemeny E, Ivanyi B. Primer: histopathology of polyoma virus-associated nephropathy in renal allografts. Nat Clin Pract Nephrol. 2006;2:631–6.
Syndman DR. Infection in solid organ transplantation. Transplant Infect Dis. 1999;1:21–8.
Kauffman CA. Diagnosis of histoplasmosis in immunosuppressed patients. Curr Opin Infect Dis. 2008;21:421–5.
Wheat LJ, Freifeld AG, Kleiman MB, Baddley JW, McKinsey DS, Loyd JE, et al. Clinical practice guidelines for management of histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45:807–25.
Tan BH, Cheah FK, Chew S, Ahmed Q. A renal transplant recipient with pulmonary nodules. Transplant Infect Dis. 2005;7:18–25.
Boldorini R, Brustia M, Veggiani C, Barco D, Andorno S, Monga G. Periodic assessment of urine and serum by cytology and molecular biology as a diagnostic tool for BK virus nephropathy in renal transplant patients. Acta Cytol. 2005;49:235–43.
Vera-Sempere FJ, Rubio L, Moreno-Baylach MJ, García A, Prieto M, Camañas A, et al. Polymerase chain reaction detection of BK virus and monitoring of BK nephropathy in renal transplant recipients at the University Hospital La Fe. Transplant Proc. 2005;37:3770–3.
Chugh KS, Sakhuja V, Jain S, Talwar P, Minz M, Joshi K, Indudhara R. High mortality in systemic fungal infections following renal transplantation in third-world countries. Nephrol Dial Transplant. 1993;8:168–72.
Einollahi B, Lessan-Pezeshki M, Pourfarziani V, Nemati E, Nafar M, Pour-reza-Gholi F, et al. Invasive fungal infections following renal transplantation: a review of 2410 recipients. Ann Transplant. 2008;13:55–8.
Cuellar-Rodriguez J, Avery RK, Lard M, Budev M, Gordon SM, Shrestha NK, et al. Histoplasmosis in solid organ transplant recipients: 10 years of experience at a large transplant center in an endemic area. Clin Infect Dis. 2009;49:710–6.
Mourad M, Malaise J, Chaib Eddour D, De Meyer M, König J, Schepers R, et al. Correlation of mycophenolic acid pharmacokinetic parameters with side effects in kidney transplant patients treated with mycophenolate mofetil. Clin Chem. 2001;47:88–94.
Leather H, Bovette RM, Tian L, Wingard JR. Pharmacokinetic evaluation of the drug interaction between intravenous itraconazole and intravenous tacrolimus or intravenous cyclosporine A in allogeneic hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant. 2006;12:325–34.
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Sharma, A., Gupta, R., Ahuja, A. et al. Renal allograft recipient with co-existing BK virus nephropathy and pulmonary histoplasmosis: report of a case. Clin Exp Nephrol 14, 641–644 (2010). https://doi.org/10.1007/s10157-010-0332-x
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DOI: https://doi.org/10.1007/s10157-010-0332-x