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Antimicrobial-susceptible patterns of Staphylococcus aureus isolated from surgical infections: a new approach

  • Original Article
  • Published:
Journal of Infection and Chemotherapy

Abstract

Our goal was to analyze minimum inhibitory concentration (MIC) data for Staphylococcus aureus isolated from surgical infections (SIs) and to look for correlations among the clinically available antimicrobials that were tested. Clinical isolates from SIs were collected by a multicenter surveillance group involving 34 institutions in Japan. During the period April 1998 to March 2007, 312 strains of S. aureus [71 methicillin susceptible (MSSA) and 241 methicillin resistant (MRSA)] were consecutively obtained from these institutions. MIC data for 18 clinically available antimicrobial agents [ABPC, CEZ, CTM, CMX, CPR, FMOX, CFPM, CZOP, IPM, MEMP, GM, ABK, MINO, CLDM, FOM, LVFX, VCM, and TEIC (abbreviations defined in Tables 2 and 3)] against these isolates was analyzed using a principal component analysis (PCA). PCA revealed that four principal components explained 71.1% of the total variance. The first component consisted of major contributions from MEPM and IPM. The second component consisted of major contributions from MINO. These two-first axes, which were strong and explained 54.2% of the total variance, were able to classify the clinical isolates into four clusters. Furthermore, the proportion of the four clusters provided the characteristics of the S. aureus that were clinically isolated at each institute. PCA is a clinically applicable method for analyzing MIC patterns. Such analyses might contribute to the establishment of a practical classification of antimicrobial agents and to the identification of the characteristic antimicrobial resistance patterns at each institute.

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Acknowledgments

The following individuals and institutions participated in the Surveillance Study Group on Pathogens of Surgical Infection: Masamitsu Hasegawa, Department of Surgery, NTT West Tokai Hospital; Koichi Hirata, Tomohisa Furuhata and Tohru Mizukuchi, First Department of Surgery, Sapporo Medical University, School of Medicine; Hiroyuki Osanai, Department of Surgery, Sapporo Gekakinen Hospital; Yoshiyuki Yanai, Department of Surgery, Medical Corporation Teishinkai Shinsapporokeiaikai Hospital; Fumitaka Hata, Department of Surgery, Sapporo Doto Hospital; Kazuaki Sasaki, Tetsufumi Someya, Keisuke Harada and Keisuke Oono, Department of Surgery, Otaru Ekisaikai Hospital; Shoji Tokita and Masashi Nakamura, Department of Surgery, Noboribetsu Kosei-Nenkin Hospital; Hitoshi Shibuya, Department of Surgery, Muroran City General Hospital; Itaru Hasegawa, Masami Kimura, Hideki Oshima and Hideki Maeda, Department of Surgery, Hokkaido Saiseikai Otaru Hospital; Mitsuhiro Mukaiya and Chikasi Kihara, Department of Surgery, Hokkaidou Social Service Association Hakodate Hospital; Watabe Kosho, Department of Surgery, Akabira General Hospital; Tsuyoshi Hoshikawa and Hitoshi Kimura, Department of Surgery, Takikawa Municipal Hospital; Yasuhide Ushijima and Yoo Yae-Hoon, Department of Surgery, National Hospital Organization, Saitama National Hospital; Jiro Yura, Digestive Disease Center, Matsunami General Hospital; Hiromitsu Takeyama and Takehiro Wakasugi, Nagoya City University Graduate School of Medical Sciences, Department of Gastroenterological Surgery; Masaaki Taniguchi, Department of Surgery, Ookuma Hospital; Isamu Mizuno and Takuji Fukui, Department of Surgery, Nagoya Midori Municipal Hospital; Keiji Mashita, Department of Surgery, Bisai Hospital; Syu Ishikawa, Department of Surgery, Kariya Toyota General Hospital, Takahama Branch; Akira Mizuno, Department of Surgery, Inabe General Hospital; Noriaki Moori and Naoki Sumita, Department of Surgery, Chita Kosei Hospital; Shoji Kubo and Shigeru Lee, Department of Gastroenterological and Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine; Toru Oomura, Department of Surgery, Fujiidera City Hospital; Yasuhito Kobayashi and Takeshi Tsuji, Department of Surgery, Wakayama Rosai Hospital; Hiroki Yamaue and Manabu Kawai, Second Department of Surgery, Wakayama Medical School; Yoshio Takesue, Department of Infection Control, Hyogo Medical School; Noriaki Tanaka, Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Hideyuki Kimura, Department of Surgery, Okayama Saiseikai Hospital; Hiromi Iwagaki, Department of Surgery, National Hospital Organization, Fukuyama National Hospital; Taijiro Sueda, Eiso Hiyama, Yoshiaki Murakami, Hiroki Ooge and Kenichiro Uemura, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University; Hiroaki Tsumura, Department of Surgery, Hiroshima City Funairi Hospital; Takashi Yokoyama, Aki City Hospital; Hitoshi Takeuchi and Kouji Tanakaya, Department of Surgery, National Hospital Organization, Iwakuni National Hospital; Yoichi Yasunami and Shinichiro Ryu, Department of Surgery 1, Fukuoka University, School of Medicine, and Department of Emergency and Critical Care Medicine, School of Medicine, Keio University.

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Authors and Affiliations

  1. Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Masaru Suzuki, Masaru Miyaki, Kazuhiko Sekine, Tomohiro Kurihara, Shinya Abe & Naoki Aikawa

  2. Tokyo Healthcare University and Postgraduate School, Tokyo, Japan

    Nagao Shinagawa

Authors
  1. Masaru Suzuki
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  2. Masaru Miyaki
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  3. Kazuhiko Sekine
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  4. Tomohiro Kurihara
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  5. Shinya Abe
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  6. Naoki Aikawa
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  7. Nagao Shinagawa
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Corresponding author

Correspondence to Masaru Suzuki.

Additional information

This article is from the Surveillance Study Group on Pathogens of Surgical Infection. The list of individuals and institutions who participated is given in “Acknowledgments”.

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Suzuki, M., Miyaki, M., Sekine, K. et al. Antimicrobial-susceptible patterns of Staphylococcus aureus isolated from surgical infections: a new approach. J Infect Chemother 17, 34–39 (2011). https://doi.org/10.1007/s10156-010-0096-y

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  • DOI: https://doi.org/10.1007/s10156-010-0096-y

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