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Disseminated cryptococcal infection with eosinophilia in a healthy person

  • Case Report
  • Published:
Journal of Infection and Chemotherapy

Abstract

A 23-year-old man with no recent medical history was hospitalized complaining of high fever and cough. In addition to very marked eosinophilia, chest X-ray revealed extensive bronchovascular bundle thickening. Transbronchial lung biopsy (TBLB) showed moderate eosinophil infiltration. Cryptococcus neoformans infection was diagnosed, based on blood culture, cerebrospinal fluid culture, urine culture, and lung biopsy specimens. The eosinophilia was successfully alleviated by treatment for cryptococcal meningitis. Furthermore, cryptococcal sepsis resolved with amphotericin B and 5-flucytosine treatment. Eosinophilia commonly occurs following chronic Aspergillus infection, but the present case suggests the involvement of Cryptococcus in another mechanism for eosinophilia.

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Authors and Affiliations

  1. Department of Respiratory Internal Medicine, St. Marianna University School of Medicine, Yokohama-city Seibu Hospital, 1197-1 Yasashi-cho, Asahi-ku, Yokohama, 241-0811, Japan

    Hiromichi Yamaguchi, Yuko Komase, Mizuki Ikehara & Takahito Yamamoto

  2. Department of Pathology, St. Marianna University School of Medicine, Yokohama-city Seibu Hospital, Yokohama, Japan

    Toshihito Shinagawa

Authors
  1. Hiromichi Yamaguchi
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  2. Yuko Komase
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  3. Mizuki Ikehara
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  4. Takahito Yamamoto
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  5. Toshihito Shinagawa
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Corresponding author

Correspondence to Hiromichi Yamaguchi.

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Yamaguchi, H., Komase, Y., Ikehara, M. et al. Disseminated cryptococcal infection with eosinophilia in a healthy person. J Infect Chemother 14, 319–324 (2008). https://doi.org/10.1007/s10156-008-0618-z

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  • DOI: https://doi.org/10.1007/s10156-008-0618-z

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