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Mifepristone (RU486), a pure antiprogesterone drug, in combination with vinblastine for the treatment of progesterone receptor-positive desmoid tumor

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Abstract

We report the case of a patient who developed a desmoid tumor following total proctocolectomy and J-pouch reconstruction that was unresponsive to any medical treatment. Based on estrogen receptor alpha (ERα) and progesterone receptor (PR) evaluation (ERα-negative, but PR-positive), treatment with mifepristone, a pure antiprogesterone drug, was initiated, and partial tumor regression was achieved.

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Authors and Affiliations

  1. Division of Surgery, Assaf Harofeh Medical Center (Affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel), Zerifin, Israel

    A. Halevy, I. Samuk, Z. Halpern & Y. Ziv

  2. Department of Radiology, Assaf Harofeh Medical Center (Affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel), Zerifin, Israel

    L. Copel

  3. Institute of Pathology, Assaf Harofeh Medical Center (Affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel), Zerifin, Israel

    J. Sandbank

Authors
  1. A. Halevy
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  2. I. Samuk
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  3. Z. Halpern
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  4. L. Copel
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  5. J. Sandbank
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  6. Y. Ziv
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Correspondence to A. Halevy.

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Halevy, A., Samuk, I., Halpern, Z. et al. Mifepristone (RU486), a pure antiprogesterone drug, in combination with vinblastine for the treatment of progesterone receptor-positive desmoid tumor. Tech Coloproctol 14, 265–267 (2010). https://doi.org/10.1007/s10151-010-0591-2

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  • DOI: https://doi.org/10.1007/s10151-010-0591-2

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