Skip to main content

Advertisement

SpringerLink
Log in

Pilot study of intraperitoneal administration of paclitaxel and oral S-1 for patients with peritoneal metastasis due to advanced gastric cancer

  • Original Article
  • Published:
International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

There is no standard treatment for peritoneal dissemination from gastric cancer. A novel combination chemotherapy has been introduced for patients with advanced gastric cancer with peritoneal metastasis.

Methods

This pilot study was performed on four patients to confirm safety and efficacy. They were diagnosed with unresectable gastric cancer with severe peritoneal dissemination by staging laparoscopy, or with metastasis to the transverse colon. We selected combined chemotherapy with both paclitaxel and S-1. Paclitaxel at 60 mg/m2 or 60 mg/body was administered intraperitoneally on days 1 and 8 and S-1, at 80–120 mg/body, was administered orally for 14 days followed by 7 days’ rest, as one course. After five courses of this therapy, the primary gastric tumors were evaluated by conventional examinations, and second-look laparoscopy was performed to assess the efficacy of the treatment against the peritoneal metastases.

Results

After five courses, primary tumor reductions were confirmed, and no cancer cells were detected on pathocytological investigation during second-look laparoscopy in any of the patients. Three patients underwent total gastrectomy with lymph node dissection and one underwent left upper abdominal evisceration. Final histological staging showed two stage 3 and two stage 4 patients. The intraperitoneal administration of paclitaxel and the oral administration of S-1 were well tolerated. Three patients died, at 8, 15, and 29 months, respectively, after the initial treatment, and one has been alive for 54 months without recurrence.

Conclusion

This chemotherapy can be used in the treatment of patients with peritoneal metastasis of gastric cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yonemura Y, Sawa T, Kinoshita K, et al. (1993) Neoadjuvant chemotherapy for high-grade advanced gastric cancer. World J Surg 17:256–262

    Article  PubMed  CAS  Google Scholar 

  2. Mochiki E, Ohno T, Kamiyama Y, et al. (2006) Phase I/II study of S-1 combined with paclitaxel in patients with unresectable and/or recurrent advanced gastric cancer. Br J Cancer 95:1642–1647

    Article  PubMed  CAS  Google Scholar 

  3. Yoshida K, Ninomiya M, Takakura N, et al. (2006) Phase II study of docetaxel and S-1 combination therapy for advanced or recurrent gastric cancer. Clin Cancer Res 12:3402–3407

    Article  PubMed  CAS  Google Scholar 

  4. Sugerbaker PH, Yonemura Y (2000) Clinical pathway for the management of resectable gastric cancer with peritoneal seeding: best palliation with a ray of hope for cure. Oncology 58:96–107

    Article  Google Scholar 

  5. Fujimoto S, Takahashi M, Kobayashi K, et al. (1993) Relation between clinical and histologic outcome of intraperitoneal hyperthermic perfusion for patients with gastric cancer and peritoneal metastasis. Oncology 50:338–343

    Article  PubMed  CAS  Google Scholar 

  6. Yonemura Y, Kawamura T, Bandou S, et al (2005) Treatment of peritoneal dissemination from gastric cancer by peritonectomy and chemohyperthermic peritoneal perfusion. Br J Surg 92:370–375

    Article  PubMed  CAS  Google Scholar 

  7. Markman M, Rowinsky E, Harkes T, et al. (1992) Phase I trial of intraperitoneal Taxol: a Gynecoloic Oncology Group Study. J Clin Oncol 10:1485–1491

    PubMed  CAS  Google Scholar 

  8. Sakata Y, Ohtsu A, Horikoshi N, et al. (1998) Late phase II study on novel oral fluoropyrimidine anticancer drug S-1 (I M tegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients. Eur J Cancer 34:1715–1720

    Article  PubMed  CAS  Google Scholar 

  9. Koizumi W, Kurihara M, Nakano S, et al. (2000) Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer. Oncology 58:191–197

    Article  PubMed  CAS  Google Scholar 

  10. Mori T, Fujiwara Y, Yano M, et al. (2003) Prevention of peritoneal metastasis of human gastric cancer cells in nude mice by S-1, a novel oral derivative of 5-fluorouracil. Oncology 64:176–182

    Article  PubMed  CAS  Google Scholar 

  11. Japanese Gastric Cancer Association (1998) Japanese classification of gastric carcinoma. 2nd English edition. Gastric Cancer 1:25–30

    Article  Google Scholar 

  12. Japanese Research Society for Gastric Cancer (1995) Japanese classification of gastric carcinoma. 1st English edn. Kanehara, Tokyo

    Google Scholar 

  13. Koizumi W, Kurihara M, Tanabe S, et al. (1999) Advantage of Japanese response criteria for estimating the survival of patients with primary gastric cancer. Gastric Cancer 2:14–19

    Article  PubMed  Google Scholar 

  14. Kakeji Y, Maehara Y, Tomoda M, et al. (1998) Long term survival of patients with stage IV gastric cancer. Cancer 82:2307–2311

    Article  PubMed  CAS  Google Scholar 

  15. Kashiwara A, Takahashi T, Kojima O, et al. (1992) Prophylaxis with carbon-absorbed mitomycin C against peritoneal recurrence of gastric cancer. Lancet 339:629–631

    Article  Google Scholar 

  16. Yonemura Y, Bandou E, Sawa T, et al. (2006) Neoadjuvant treatment of gastric cancer with peritoneal dissemination. Eur J Surg Oncol 32:661–665

    Article  PubMed  CAS  Google Scholar 

  17. Francis P, Rowinsky E, Schneider J, et al. (1995) Phase 1 feasibility and pharmacologic study of weekly intraperitoneal paclitaxel: a Gynecologic Oncology Group pilot study. J Clin Oncol 13:2961–2967

    PubMed  CAS  Google Scholar 

  18. Markman M, Brady MF, Spirtos NM, et al. (1998) Phase II trial of intraperitoneal Taxol in carcinoma of the ovary, tube, and peritoneum: a Gynecologic Oncology Group Study. J Clin Oncol 16:1485–1491

    Google Scholar 

  19. Los G, Mutsaers PHA, van der Vijgh WJF, et al. (1989) Direct diffusion of cis-diamminedichloroplatinum(II) in intraperitoneal rat tumors after intraperitoneal chemotherapy: a comparison with systemic chemotherapy. Cancer Res 49:3380–3384

    PubMed  CAS  Google Scholar 

  20. Los G, van Vugt MJH, Pinedo HM, et al. (1994) Response of peritoneal solid tumors after intraperitoneal chemo-hyperthermia treatment with cisplatin and carboplatin. Br J Cancer 68:235–241

    Google Scholar 

  21. Fushida S, Furui N, Kinami S, et al. (2002) Pharmacologic study of intraperitoneal paclitaxel in gastric cancer patients with peritoneal dissemination (in Japanese). Gan To Kagaku Ryoho (Jpn J Cancer Chemother) 29:2164–2167

    Google Scholar 

  22. Yonemura Y, Endou Y, Bando E, et al. (2004) Effect of intraperitoneal administration of docetaxel on peritoneal dissemination of gastric cancer. Cancer Lett 210:189–196

    Article  PubMed  CAS  Google Scholar 

  23. Tamura S, Miki H, Nakata K, et al. (2007) Intraperitoneal administration of paclitaxel and oral S-1 for a patient with peritoneal dissemination and hydronephrosis due to advanced gastric cancer. Gastric Cancer 10:251–255

    Article  PubMed  CAS  Google Scholar 

  24. Shirasaka T, Shimamoto Y, Ohshimo H, et al. (1996) Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs 7:548–557

    Article  PubMed  CAS  Google Scholar 

  25. Osugi H, Takada N, Takemura M, et al. (2002) Oral fluoropyrimidine anticancer drug TS-1 for gastric cancer patients with peritoneal dissemination. Oncol Rep 9:811–815

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki, Hyogo, 660-8511, Japan

    Shigeyuki Tamura, Hirofumi Miki, Kaoru Okada, Tomohiro Miyake, Mio Yoshimura, Rei Suzuki, Shin Nakahira, Ken Nakata, Shu Okamura, Keishi Sugimoto & Yuichi Takatsuka

Authors
  1. Shigeyuki Tamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hirofumi Miki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kaoru Okada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tomohiro Miyake
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mio Yoshimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rei Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Shin Nakahira
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ken Nakata
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Shu Okamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Keishi Sugimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yuichi Takatsuka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shigeyuki Tamura.

About this article

Cite this article

Tamura, S., Miki, H., Okada, K. et al. Pilot study of intraperitoneal administration of paclitaxel and oral S-1 for patients with peritoneal metastasis due to advanced gastric cancer. Int J Clin Oncol 13, 536–540 (2008). https://doi.org/10.1007/s10147-008-0836-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10147-008-0836-5

Key words

Search

Navigation