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Risk factors for perianeurysmal vasogenic oedema (pavo) following embolization therapy: literature review

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Abstract  

Perianeurysmal vasogenic oedema (PAVO) is a rare complication associated post–embolisation of intracranial aneurysms. The prevalence, risk factors predisposing to susceptibility, and pathologic mechanisms underlying this process are not clearly understood. Since this complication may be associated with poor clinical outcomes, the authors designed this study to describe possible risk factors, underlying mechanisms, and management of PAVO through published case reports. Developing a priori protocol according to PRISMA guidelines, we searched MEDLINE/PubMed, Embase and Web of Science to identify case studies and reports of adult patients with intracranial aneurysms who developed perianeurysmal oedema following coil embolization therapy. Data extracted from these studies included patient demographics, aneurysm characteristics, coil type, PAVO characteristics, treatment, and outcomes. Quality was assessed using a standardized tool. 21 eligible studies of acceptable quality were identified, comprising 40 unique cases from 9 countries. The mean patient age was 56.4 years and 25 (62.5%) were female. Aneurysm size ranged from 6 to 30 mm, with a mean size of 15.2 mm; only 6 (15%) of cases were giant intracranial aneurysm (≥ 25 mm). The more frequent locations of intracranial aneurysms associated with PAVO were the ICA (50%) and posterior circulation (32.5%), with 7.5% and 10% of cases occurring in MCA and anterior circulation, respectively. 16 cases (40%) were treated with bare platinum coils, and 14 (35%) with a combination of BPCs and bioactive coils; in 10 cases (25%), the coil type was not mentioned. PAVO presented between 0 days and 8 years of coil embolization, with 23 (57.5% cases) presenting symptomatically in relation to brain region affected. Management strategies for PAVO included conservative, steroids, re–embolization, clipping, stenting, parent artery occlusion either as monotherapy or as combination therapy. Of reported studies, 26 treated cases (65%) resolved, with 8 (20%) remaining stable, and 4 (10%) deteriorating. PAVO can be associated with small or large intracranial aneurysms, bare and bioactive platinum coils, and all regions of the intracranial circulation. The understanding of the risk factors of this complication lies in the underlying mechanisms, which will ultimately guide appropriate patient follow–up and subsequent optimal management.

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Authors and Affiliations

  1. School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0SP, UK

    Emmanuel O. Mensah & Abdul R. Abusellie

  2. Department of Neurosurgery, Royal Preston Hospital, Preston, PR2 9HT, UK

    Catherine Pringle, Andrew F. Alalade & Gareth A. Roberts

  3. Department of Neurology, Royal Preston Hospital, Preston, PR2 9HT, UK

    Hedley Emsley

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Contributions

EM, ARA and AFA contributed to the study conception and design. Material preparation, data collection and analysis were performed by EM, ARA and AFA. The first draft of the manuscript was written by EM, ARA and AFA. All authors (EM, ARA, CP, HE, AFA, GAR) commented on previous versions of the manuscript. All authors (EM, ARA, CP, HE, AFA, GAR) read and approved the final manuscript.

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Correspondence to Andrew F. Alalade.

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Mensah, E.O., Abusellie, A.R., Pringle, C. et al. Risk factors for perianeurysmal vasogenic oedema (pavo) following embolization therapy: literature review. Neurosurg Rev 46, 266 (2023). https://doi.org/10.1007/s10143-023-02168-0

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