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Papillary meningioma of the central nervous system: a SEER database analysis

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Abstract

Papillary meningioma (PM) is a rare central nervous system tumor. We aimed to analyze the characteristics and outcomes of patients with PM (WHO grade III) and identify risk factors that influence survival using the Surveillance, Epidemiology, and End Results (SEER) database. Clinical characteristics, tumor features, and outcomes of 108 PM patients included in the SEER database between 1990 and 2016 were retrieved. Risk factors related to prognosis of PM were assessed by Kaplan–Meier curves and the Cox proportional hazards model. All 108 patients, including 65 males and 43 females (1.5:1), with a median age of 52 years (range, 9 to > 85 years) had undergone surgical resection. Gross total resection (GTR) was achieved in 50%, and 50% underwent subtotal resection (STR). While 55.6% underwent postoperative radiation therapy, 48% did not. The median disease-specific survival (DSS) was 128 months, and the 5-year DSS rate was 77%. In multivariate analysis, age ≤ 52 years and GTR were both independently associated with higher probability of DSS (p = 0.033 and p = 0.029, respectively). Stratification analysis showed that postoperative radiotherapy had no significant impact on the DSS, irrespective of resection extent (p = 0.172). Our SEER analysis showed that age and extent of resection were prognostic factors for PM, but race, tumor size, gender, chemotherapy, and postoperative radiotherapy did not significantly impact DSS of PM patients. There was no significant improvement in survival of patients who underwent radiotherapy and GTR, or radiotherapy and STR, compared with GTR or STR alone.

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The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

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Authors and Affiliations

  1. Department of Neurosurgery, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, 610041, Sichuan, China

    Fujun Liu, Yuan Tian & Liangxue Zhou

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  1. Fujun Liu
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  2. Yuan Tian
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Contributions

FJ Liu: conceptualization, writing of original draft, review, and editing. LX Zhou: investigation, supervision and validation. Y Tian: data collection. All the authors have read and agreed to the published version of the manuscript.

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Correspondence to Liangxue Zhou.

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The authors declare that they have no conflicts of interest.

Ethical approval

This study was reviewed and approved by the Ethics Board at Sichuan University (Reference number: 2018-061).

Statement of human and animal rights

All procedures performed in this study involving human participants were in accordance with the ethical standards of the West China Hospital, national research committee, and 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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This is a population study that involved no identifiable information for individuals throughout the analyses. Data were obtained in accordance with SEER database policies.

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Liu, F., Tian, Y. & Zhou, L. Papillary meningioma of the central nervous system: a SEER database analysis. Neurosurg Rev 44, 2777–2784 (2021). https://doi.org/10.1007/s10143-020-01449-2

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  • DOI: https://doi.org/10.1007/s10143-020-01449-2

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