Abstract
High-resolution sonography has a growing role in both the diagnosis and management of traumatic and atraumatic peripheral nerve pathology. Sonography not only affords a cost-effective and time-efficient approach to interrogating long segments of peripheral nerves but also possesses unique advantages in terms of its dynamic, real-time nature with few clinical contraindications and limitations. In this review, we will initially discuss imaging techniques and characteristics of normal neural sonohistology, then address specific features and pitfalls pertaining to the spectrum of post-traumatic peripheral nerve injury. Additionally, we will highlight the more common sonographic applications in the clinical work-up of patients presenting with symptoms of dynamic neural impingement and entrapment. Finally, illustrative and clinical features of the more frequently encountered peripheral neural neoplastic pathologies will be addressed.
Similar content being viewed by others
References
Ali Z, Pisapia J, Zager E et al (2016) Ultrasonographic evaluation of peripheral nerves. World Neurosurg 85:333–339
Zaidman C, Seelig M, Baker J et al (2013) Detection of peripheral nerve pathology: a comparison of ultrasound and MRI. Neurology 80:1634–1640
Tagliafico A, Tagliafico G (2014) Fascicular ratio: a new parameter to evaluate peripheral nerve pathology on magnetic resonance imaging: a feasibility study on a 3T system. Medicine 93:e68
Koenig R, Pedro M, Heinen C et al (2009) High-resolution ultrasonography in evaluating peripheral nerve entrapment and trauma. Neurosurg Focus 26(2):E13
Martinolli C, Bianchi S, Derechi L (2000) Ultrasonography of peripheral nerves. Semin Ultrasound CT MR 21:205–213
Cartwright M, Passamore L, Yoon J et al (2008) Cross-sectional area reference values for nerve ultrasonography. Muscle Nerve 37:394–396
Silvestri E, Martinoli C, Derechi L et al (1995) Echotexture of peripheral nerves: correlation between US and histologic findings and criteria to differentiate tendons. Radiology 197:291–296
Watanabe T, Ito H, Sekine A, Katano Y, Nishimura T, Kato Y, Takeda J, Seishima M, Matsuoka T (2010) Sonographic evaluation of the peripheral nerve in diabetic patients: the relationship between nerve conduction studies, echo intensity, and cross-sectional area. J Ultrasound Med 29:697–708
Seddon H (1942) A classification of nerve injuries. Br Med J 2:237–239
Lauretti L, D’Alessandris Q, Granata G et al (2015) Ultrasound evaluation in traumatic peripheral nerve lesions: from diagnosis to surgical planning and follow-up. Acta Neurochir 157:1947–1951
Smith J, Miller M, Carroll C et al (2016) High-resolution ultrasound in combat-related peripheral nerve injuries. Muscle Nerve 54:1139–1144
Kele H (2012) Ultrasonography of the peripheral nervous system. Perspect Med 1:417–421
Kopf H, Loizides A, Mostbeck G, Gruber H (2011) Diagnostic sonography of peripheral nerves: indications, examination techniques and pathological findings. Ultraschall Med 32:242–263
Toia F, Gagliardo A, D’Arpa S et al (2016) Preoperative evaluation of peripheral nerve injuries: what is the place for ultrasound? J Neurosurg 125:603–614
Kara M, Ozcakar L, DeMuynck M et al (2012) Musculoskeletal ultrasound for peripheral nerve lesions. Eur J Phys Rehabil Med 48:665–674
Padua L, Di Pasquale A, Liotta G et al (2013) Ultrasound as a useful tool in the diagnosis and management of traumatic nerve injuries. Clin Neurophysiol 124:1237–1243
Zhu J, Liu F, Li D et al (2011) Preliminary study of the types of traumatic peripheral nerve injuries by ultrasound. Eur Radiol 21:1097–1101
Kara M, Ozcakar L, Komurcu E et al (2012) Sonographic evaluation of sciatic nerves in patients with unilateral sciatica. Arch Phys Med Rehab 93:1593–1602
Bianchi S (2008) Ultrasound of the peripheral nerves. Joint Bone Spine 75:643–649
Jacobson J, Wilson T, Yang L (2016) Sonography of common peripheral nerve disorders with clinical correlation. J Ultrasound Med 35:683–693
Lawande A, Warrier S, Joshi M (2014) Role of ultrasound in evaluation of peripheral nerves. Indian J Radiol Imaging 24:254–258
Peetrons P, Derbali W (2013) Carpal tunnel syndrome. Semin Musculoskelet Radiol 17:28–33
Ooi C, Wong S, Tan A et al (2014) Diagnostic criteria of carpal tunnel syndrome using high-resolution ultrasonography: correlation with nerve conduction studies. Skelet Radiol 43:1387–1394
Klauser A, Halpern E, DeZordo T et al (2009) Carpal tunnel syndrome assessment with US: value of additional cross-sectional area measurements of the median nerve in patients versus healthy volunteers. Radiology 250:171–177
Malhouhi A, Pultzl P, Trieb T et al (2006) Predictors of carpal tunnel syndrome: accuracy of gray-scale and color Doppler sonography. AJR 186:1240–1245
Klausner A, Abd Ellah M, Halpern E et al (2015) Sonographic cross-sectional area measurement in carpal tunnel syndrome patients: can delta and ratio calculations predict severity compared to nerve conduction studies? Eur Radiol 25:2419–2427
Propeck T, Quinn T, Jacobson J et al (2000) Sonography and MR imaging of bifid median nerve with anatomic and histologic correlation. AJR 175:1721–1775
Walker F, Cartwright M, Blocker J et al (2013) Prevalence of bifid median nerves and persistent median arteries and their association with carpal tunnel syndrome in a sample of Latino poultry processors and other manual workers. Muscle Nerve 48(4):539–544
Klauser A, Halpern E, Faschingbauer R et al (2011) Bifid median nerve in carpal tunnel syndrome: assessment with US cross-sectional area measurement. Radiology 259:808–815
Abicalaf C, de Barros N, Sernik R et al (2007) Ultrasound evaluation of patients with carpal tunnel syndrome before and after endoscopic release of the transverse carpal ligament. Clin Radiol 62:891–896
Tan T, Yeo C, Smith E (2011) High definition ultrasound as diagnostic adjunct for incomplete carpal tunnel release. J Hand Surg Am 16:289–294
Wiesler E, Chloros G, Cartwright M et al (2006) Ultrasound diagnosis of ulnar neuropathy at the cubital tunnel. J Hand Surg 31:1088–1093
Yoon J, Walker F, Cartwright M (2008) Ultrasonographic swelling ratio in the diagnosis of ulnar neuropathy at the elbow. Muscle Nerve 38:1231–1235
Frijlink D, Brekelmans G, Visser L (2013) Increased nerve vascularization detected by color Doppler sonography in patients with ulnar neuropathy at the elbow indicates axonal damage. Muscle Nerve 49:35–39
Beekman R, Schoemaker M, Van Der Plas J et al (2004) Diagnostic value of high-resolution sonography in ulnar neuropathy at the elbow. Neurology 621:767–773
Beltran L, Bencardino J, Ghazikhanian V, Beltran J (2010) Entrapment neuropathies III, lower limb. Semin Musculoskelet Radiol 14:501–511
Torriani M, Kattapuram S (2003) Technical innovation: dynamic sonography of the forefoot: the sonographic Mulder sign. AJR 180:1121–1123
Lee M, Kim S, Huh Y et al (2007) Morton neuroma: evaluated with ultrasonography and MR imaging. Korean J Radiol 8:148–155
Murphey M, Smith W, Smith S et al (1999) Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics 19:1253–1280
Chiou H, Chou Y, Chiou S et al (2003) Peripheral nerve lesions: role of high-resolution US. Radiographics 23:e15
Bodner g BW, Schocke M et al (2001) Radial nerve palsy associated with humeral shaft fracture: evaluation with US—initial experience. Radiology 219:811–816
Peer S, Bodner G, Meirer R, Willeit J, Piza-Katzer H (2001) Examination of postoperative peripheral nerve lesions with high resolution sonography. AJR 177:415–419
Simmons D, Lisle D, Linklater J (2010) Imaging of peripheral nerve lesions in the lower limb. Top Magn Reson Imaging 21:51–62
Spinner R, Desy N, Rock M et al (2007) Peroneal intraneural ganglia, part I: techniques for successful diagnosis and treatment. Neurosurg Focus 22:e16
Visser L, Hens V, Soethout M et al (2013) Diagnostic value of high-resolution sonography in common fibular mononeuropathy at the fibular head. Muscle Nerve 43(2):171–178
Tsukamoto H, Granata G, Coraci D, Paolasso I, Padua L (2014) Ultrasound and neurophysiological correlation in common fibular nerve conduction block at the fibular head. Clin Neurophysiol 125(7):1491–1495
Nagaoka M, Matsuzaki H (2005) Ultrasonography in tarsal tunnel syndrome. J Ultrasound Med 24(8):1035–1040
Fantino O, Coillard J, Borne J et al (2011) Ultrasound of the tarsal tunnel: normal and pathological imaging features. J Radiol 92(12):1072–1080
Abreu E, Aubert S, Wavreille G, Gheno R, Canella C, Cotten A (2013) Peripheral tumor and tumor-like neurogenic lesions. Eur J Radiol 82:38–50
Beaman F, Kransdorf M, Menke D (2004) Schwannoma: radiologic-pathologic correlation. Radiographics 24:1477–1481
Reynolds D, Jacobson J, Inampudi P et al (2004) Sonographic characteristics of peripheral nerve tumors. AJR 182:741–744
Lin J, Jacobson J, Hayes C (1999) Sonographic target sign in neurofibromatosis. J Ultrasound Med 18:513–517
Tsai W, Chiou H, Chou Y et al (2008) Differentiation between schwannomas and neurofibromas in the extremities and superficial body: the role of high-resolution and color Doppler ultrasonography. J Ultrasound Med 27:161–166
Benz M, Czernin J, Dry S et al (2010) Quantitative F18-flourodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer 116:451–458
Fingerman M (2011) Regional anesthesia for outpatient hand surgery: ultrasound guided peripheral nerve block. J Hand Surg [Am] 36:532–534
Lee J, Lee Y (2008) Percutaneous chemical nerve block with ultrasound-guided intraneural injection. Eur Radiol 18:1506–1512
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Mallon, S., Starcevic, V., Rheinboldt, M. et al. Sonographic evaluation of peripheral nerve pathology in the emergency setting. Emerg Radiol 25, 521–531 (2018). https://doi.org/10.1007/s10140-018-1611-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10140-018-1611-1