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Recent Advances of Marine Sponge-Associated Microorganisms as a Source of Commercially Viable Natural Products

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Abstract

Many industrially significant compounds have been derived from natural products in the environment. Research efforts so far have contributed to the discovery of beneficial natural products that have improved the quality of life on Earth. As one of the sources of natural products, marine sponges have been progressively recognised as microbial hotspots with reports of the sponges harbouring diverse microbial assemblages, genetic material, and metabolites with multiple industrial applications. Therefore, this paper aims at reviewing the recent literature (primarily published between 2016 and 2022) on the types and functions of natural products synthesised by sponge-associated microorganisms, thereby helping to bridge the gap between research and industrial applications. The metabolites that have been derived from sponge-associated microorganisms, mostly bacteria, fungi, and algae, have shown application prospects especially in medicine, cosmeceutical, environmental protection, and manufacturing industries. Sponge bacteria-derived natural products with medical properties harboured anticancer, antibacterial, antifungal, and antiviral functions. Efforts in re-identifying the origin of known and future sponge-sourced natural products would further clarify the roles and significance of microbes within marine sponges.

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Acknowledgements

Mr. Justin Brian Chiongson is acknowledged for his invaluable technical assistance in the preparation of this manuscript.

Funding

Partial financial support was received from the Postgraduate Research Grant (PGRG), Universiti Malaysia Terengganu (55193/1). The DOST-PCHRD Tuklas Lunas Development Center project award to University of San Agustin is acknowledged for supporting the drug discovery program of Center for Natural Drug Discovery & Development (CND3).

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Authors and Affiliations

  1. Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia

    Tan Suet May Amelia, Afiq Durrani Mohd Fahmi & Kesaven Bhubalan

  2. Center for Natural Drug Discovery & Development (CND3), University of San Agustin, 5000, Iloilo City, Philippines

    Ferr Angelus C. Suaberon & Jonel P. Saludes

  3. Changing Oceans Research Group, School of GeoSciences, University of Edinburgh, Edinburgh, UK

    Johanne Vad

  4. Department of Chemistry, University of San Agustin, 5000, Iloilo City, Philippines

    Jonel P. Saludes

  5. Department of Science and Technology, Balik Scientist Program, Philippine Council for Health Research & Development (PCHRD), Bicutan, 1631, Taguig, Philippines

    Jonel P. Saludes

  6. Eco-Innovation Research Interest Group, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia

    Afiq Durrani Mohd Fahmi & Kesaven Bhubalan

  7. Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia

    Kesaven Bhubalan

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  1. Tan Suet May Amelia
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  3. Johanne Vad
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Contributions

Conceptualization: Kesaven Bhubalan, Tan Suet May Amelia, Afiq Durrani Mohd Fahmi; formal analysis and investigation: Tan Suet May Amelia, Ferr Angelus C Suaberon; writing–original draft preparation: Tan Suet May Amelia, Ferr Angelus C Suaberon; writing–review and editing: Tan Suet May Amelia, Johanne Vad, Jonel P Saludes, Afiq Durrani Mohd Fahmi; supervision: Kesaven Bhubalan, Jonel P Saludes.

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Amelia, T.S.M., Suaberon, F.A.C., Vad, J. et al. Recent Advances of Marine Sponge-Associated Microorganisms as a Source of Commercially Viable Natural Products. Mar Biotechnol 24, 492–512 (2022). https://doi.org/10.1007/s10126-022-10130-2

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